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p53 and transformation by SV40
Biology of the Cell, 1986The large T antigen of SV40 is able to immortalize and transform primary and established cells in culture, and can, at least in certain cases, confer a tumorigenic phenotype on the infected cell. T antigen has been shown to induce cellular DNA synthesis in the infected cell and this activity is likely to be instrumental in T antigen mediated ...
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SV40 T-antigen is a histocompatibility antigen of SV40-transgenic mice
Immunogenetics, 1988Although the extensive family of non-H-2 histocompatibility (H) antigens provides a formidable barrier to transplantation, the origin of their encoding genes are unknown. Recent studies have demonstrated both the linkage between H genes and retroviral sequences and the ability of integrated Moloney-murine leukemia virus to encode what is operationally ...
Wettstein, P J +4 more
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Rapid small-scale isolation of SV40 virions and SV40 DNA
Journal of Virological Methods, 2000A rapid method for the small-scale isolation of SV40 virions and SV40 DNA is presented. CV-1 monkey epithelial cells are transfected with linear SV40 DNA. After the onset of transfection, cells are lysed by several freeze/thaw cycles and virions are isolated using polyethylene glycol (PEG) precipitation of DNase I treated lysates. Viral DNA is released
S J, Orlando, M, Nabavi, E, Gharakhanian
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SV40 Promoters and Their Regulation
1985Publisher Summary This chapter discusses the complex regulatory region of SV40. It may serve as a model of the regulatory mechanisms that operate in many other eukaryotic systems. The regulatory region of SV40 is 420 bp long and is contained in the HindIII–HpaII fragment located between nucleotide positions 5171 and 346 (25) .This DNA is positioned ...
G C, Das, S K, Niyogi, N P, Salzman
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1999
Simian virus 40 (SV40) has been extensively used as a model system for mammalian cell replication and gene expression and has served as a highly effective “probe” for cellular functions. This has also been the case for understanding carcinogenesis since viral gene expression can result in altered cell proliferation and appearance of multiple ...
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Simian virus 40 (SV40) has been extensively used as a model system for mammalian cell replication and gene expression and has served as a highly effective “probe” for cellular functions. This has also been the case for understanding carcinogenesis since viral gene expression can result in altered cell proliferation and appearance of multiple ...
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Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology, 1970
SV40‐transformed cell lines from 8 kidneys and 2 embryos of inbread CBA mice were grown in vitro and repeatedly tested for oncogenicity in adult syngeneic hosts by subcutaneous inoculation of about 50 × 106 cells. In contrast to spontaneously developing permanent mouse embryo lines, these in vitro lines never induced any progressive tumours.
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SV40‐transformed cell lines from 8 kidneys and 2 embryos of inbread CBA mice were grown in vitro and repeatedly tested for oncogenicity in adult syngeneic hosts by subcutaneous inoculation of about 50 × 106 cells. In contrast to spontaneously developing permanent mouse embryo lines, these in vitro lines never induced any progressive tumours.
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2003
ABSTACT: SV40 is a small simian virus that has been extensively used as a viral vector in mammalian cells (1-4). The viral genome is a double-stranded supercoiled DNA molecule of 5243 bp (Fig. 1A) that is packaged into a capsid containing the viral structural proteins VP1,VP2, and VP3. SV40 induces a lytic infection cycle in permissive cells. The first
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ABSTACT: SV40 is a small simian virus that has been extensively used as a viral vector in mammalian cells (1-4). The viral genome is a double-stranded supercoiled DNA molecule of 5243 bp (Fig. 1A) that is packaged into a capsid containing the viral structural proteins VP1,VP2, and VP3. SV40 induces a lytic infection cycle in permissive cells. The first
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Induction of SV40 T antigen with SV40 DNA
Virology, 1965P H, Black, W P, Rowe
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SV40 in adenovirus vaccines and adenovirus-SV40 recombinants.
Developments in biological standardization, 1998During the development of adenovirus (Ad) vaccines in the 1950s, Ad strains 1-5 and 7 recombined with SV40 during adaptation to growth in rhesus monkey kidney cells. The recombination events between the Ad and SV40 genomes produced hybrid viruses that contained, within the Ad genome, either portions of the early region of the SV40 genome or single or ...
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