Results 41 to 50 of about 33,665 (238)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Swarm potential fields with internal agent states and collective behaviour [PDF]

, 2007
Swarm robotics is a new and promising approach to the design and control of multi-agent robotic systems. In this paper we use a model for a system of self-propelled agents interacting via pairwise attractive and repulsive potentials.
Abdel Wahid, Mohamed Hussien Mabrouk, McInnes, Colin   +1 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Swarm Robotics: The Coordination of Robots via Swarm Intelligence Principles [PDF]

, 2008
Swarm intelligence is the discipline that deals with natural and artificial systems composed of many individuals that coordinate using decentralized control and self-organization. The discipline focuses on the collective behaviors that result from the local interactions of the individuals with each other and with their environment.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Designing a Robotic Platform for Investigating Swarm Robotics [PDF]

, 2019
This paper documents the design and subsequent construction of a low-cost, flexible robotic platform for swarm robotics research, and the selection of appropriate swarm algorithms for the implementation of a swarm focused predominantly on target location.
Gray, Jonathan
core   +1 more source

Robotic Wireless Sensor Networks

, 2018
In this chapter, we present a literature survey of an emerging, cutting-edge, and multi-disciplinary field of research at the intersection of Robotics and Wireless Sensor Networks (WSN) which we refer to as Robotic Wireless Sensor Networks (RWSN).
A Balasubramanian, A Chattopadhyay, A Fida, A Gasparri, A Gasparri, A Ghaffarkhah, A Gonzalez-Ruiz, A Gonzalez-Ruiz, A Sanfeliu, A Tiderko, AM Hsieh, AM Ladd, B Mohar, C Dixon, C Lochert, CE Perkins, CR Lin, D Calkins, D Son, D Tardioli, DV Dimarogonas, DV Dimarogonas, E Aahin, E Prassler, EA Thompson, EW Dijkstra, F Knorn, FT Dagefu, G Holland, G Sun, G Tuna, H Choset, HG Nguyen, Hui Liu, I Guvenc, J Baber, J Cortes, J Fink, J Ny Le, J Penders, J Zhou, JB Petelin, JC Curlander, JG Dai, JK Erickson, JR Pinta De La, K Fall, K Kamei, K Konolige, K Savla, KA Qaraqe, L Oliveira, L Sabattini, L Tassiulas, LE Parker, M Fiedler, M Franceschelli, M Guo, M Malmirchegini, M Mauve, M Mauve, M Michael, M Michael, M Michael, M Michael, M Naghshvar, M Saumitra, M Schuresko, MA Batalin, MA Hsieh, MD Weiss, N Bezzo, N Boillot, N Hazon, N Xiong, NP Papanikolopoulos, O Tekdas, P Brass, P Wilke, P Yang, P Yang, P. Ibach, Pradipta Ghosh, Pradipta Ghosh, PX Liu, Q Dong, R Olfati-Saber, RC Arkin, RR Murphy, RR Murphy, S Depatla, S Gil, S Manfredi, S Thrun, S Wang, SJ Lee, SR Theodore, T Gustavi, V Milanés, Y Mostofi, Y Mostofi, Y Mostofi, Y Mostofi, Y Uchimura, Y Yan, Y Yan, Z Lin   +106 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Distributed Epigenetic Shape Formation and Regeneration Algorithm for a Swarm of Robots

, 2018
Living cells exhibit both growth and regeneration of body tissues. Epigenetic Tracking (ET), models this growth and regenerative qualities of living cells and has been used to generate complex 2D and 3D shapes.
Cheng Jimming, Fontana Alessandro, Kumar Vignesh, Schmickl Thomas   +3 more
core   +1 more source