Results 51 to 60 of about 3,346 (249)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Recent Advances in Swarm Robotics Coordination: Communication and Memory Challenges
Applied Sciences, 2022 Swarm robotics research has been present for some decades, providing nature-inspired algorithms in swarms of robots [...]
Álvaro Gutiérrez
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Intelligent Control of Electric Vehicle Drives using Swarm Robotics [PDF]
E3S Web of ConferencesThis study investigates the incorporation of swarm robotics into the control mechanism of electric vehicles (EVs), introducing an innovative intelligent control framework that utilizes the concepts of decentralized decision-making. The research entails a
Usanova Kseniia Iurevna +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
On Formal Specification of Emergent Behaviours in Swarm Robotic Systems
International Journal of Advanced Robotic Systems, 2008 It is a characteristic of swarm robotics that specifying overall emergent swarm behaviours in terms of the low-level behaviours of individual robots is very difficult.
Clare Dixon +4 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Frontiers in Robotics and AI, 2018 We introduce the Xpuck swarm, a research platform with an aggregate raw processing power in excess of two teraflops. The swarm uses 16 e-puck robots augmented with custom hardware that uses the substantial CPU and GPU processing power available from ...
Simon Jones +8 more
doaj +1 more source
Frontiers in Robotics and AI, 2020 Stigmergy is a form of indirect communication and coordination in which agents modify the environment to pass information to their peers. In nature, animals use stigmergy by, for example, releasing pheromone that conveys information to other members of ...
Muhammad Salman +3 more
doaj +1 more source