Furin Cleavage Is Required for Swine Acute Diarrhea Syndrome Coronavirus Spike Protein-Mediated Cell – Cell Fusion [PDF]
Emerging Microbes and Infections, 2022 Swine acute diarrhea syndrome coronavirus (SADS-CoV) was reported in China in 2017 and is a causative agent of porcine enteric disease. Recent studies indicate that cells from various hosts are susceptible to SADS-CoV, suggesting the zoonotic potential of this virus.
Jung-Eun Park, Jinman Kim
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A Customized Novel Blocking ELISA for Detection of Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Infection. [PDF]
Microbiol Spectr, 2023 SADS-CoV was reported to be of high potential for dissemination among various of host species. Accurate serological diagnosis of SADS-CoV infection is key in managing the emerging SADS-CoV.
Cao L +8 more
europepmc +5 more sources
RNA-Seq-Based Whole Transcriptome Analysis of IPEC-J2 Cells During Swine Acute Diarrhea Syndrome Coronavirus Infection [PDF]
Frontiers in Veterinary Science, 2020 The new emergence of swine acute diarrhea syndrome coronavirus (SADS-CoV) has resulted in high mortality in suckling pigs in China. To date, the transcriptional expression of host cells during SADS-CoV infection has not been documented. In this study, by
Fanfan Zhang +22 more
doaj +5 more sources
Swine Enteric Alphacoronavirus (Swine Acute Diarrhea Syndrome Coronavirus): An Update Three Years After Its Discovery [PDF]
Virus Research, 2020 Discovered in 2017, swine enteric alphacoronavirus (SeACoV), also known as swine acute diarrhea syndrome coronavirus (SADS-CoV) or porcine enteric alphacoronavirus (PEAV), is the fifth porcine CoV identified in diarrheal piglets. The presumed name "SADS-CoV" may not be appropriate since current studies have not provided strong evidence for high ...
Yao-Wei Huang, Yong-Le Yang
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PABPC1 Restricts Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Infection via TOLLIP-Mediated Degradation of Viral Nucleocapsid Protein [PDF]
PathogensThe emergence of swine acute diarrhea syndrome coronavirus (SADS-CoV), an alpha-coronavirus that causes fatal enteric disease in neonatal piglets with mortality rates up to 90%, demonstrates that bat-origin coronavirus has expanded its host range to pigs.
Yu Zhang, Cong Yuan, Yueyue Duan
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The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs
Microorganisms, 2022 Coronaviruses, mainly including severe acute respiratory syndrome virus, severe acute respiratory syndrome coronavirus 2, Middle East respiratory syndrome virus, human coronavirus OC43, chicken infectious bronchitis virus, porcine infectious ...
Sen Zeng +13 more
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Swine Acute Diarrhea Syndrome Coronavirus Replication Is Reduced by Inhibition of the Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway [PDF]
Virology, 2022 Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered enteric coronavirus. We have previously shown that the caspase-dependent FASL-mediated and mitochondrion-mediated apoptotic pathways play a central role in SADS-CoV-induced apoptosis, which facilitates viral replication.
Tingshuai Feng, Zhaoyang Jing, Dakai Liu
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Vaccines, 2023 Swine enteric coronaviruses (SECs) cause significant economic losses to the pig industry in China. Although many commercialized vaccines against transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are available, viruses ...
Fanzhi Kong +4 more
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Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance The emergence of new human and animal coronaviruses demand novel strategies that characterize the threat potential of newly discovered zoonotic strains. We synthetically recovered recombinant wild-type and derivative swine acute diarrhea syndrome coronaviruses (SADS-CoVs) that express indicator genes and characterized ...
Edwards CE +13 more
europepmc +6 more sources
STING Agonist diABZI Confers Protection Against Swine Acute Diarrhea Syndrome Coronavirus in Neonatal Mice by Activating Antiviral Immunity [PDF]
Journal of VirologyABSTRACT The recently identified alphacoronavirus swine acute diarrhea syndrome coronavirus (SADS-CoV) has a high fatality rate in neonatal piglets. Currently, no vaccines or treatment strategies for SADS-CoV infection are available.
Jiyong Zhou, Wenchao Sun, Huijun Lu
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