Results 31 to 40 of about 2,971,207 (141)

Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Antagonizes Interferon-β Production via Blocking the Interaction Between TRAF3 and TBK1 [PDF]

Frontiers in Immunology, 2021
Swine acute diarrhea syndrome coronavirus (SADS-CoV), first discovered in 2017, is a porcine enteric coronavirus that can cause acute diarrhea syndrome (SADS) in piglets.
Zhihai Zhou, Zhihai Zhou, Yuan Sun, Yuan Sun, Jingya Xu, Jingya Xu, Xiaoyu Tang, Xiaoyu Tang, Ling Zhou, Ling Zhou, Qianniu Li, Qianniu Li, Tian Lan, Tian Lan, Jingyun Ma, Jingyun Ma   +15 more
doaj   +2 more sources

The Effects of Swine Coronaviruses on ER Stress, Autophagy, Apoptosis, and Alterations in Cell Morphology

Pathogens, 2022
Swine coronaviruses include the following six members, namely porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine ...
Ya-Mei Chen, Eric Burrough
doaj   +2 more sources

Swine acute diarrhea syndrome coronavirus nsp5 induces apoptosis by targeting GATA zinc finger domain-containing protein 2A (GATAD2A/p66α) [PDF]

mBio
Swine acute diarrhea syndrome coronavirus (SADS-CoV) causes severe enteric disease in neonatal piglets, resulting in substantial economic losses worldwide.
Haixin Huang, Xin Wang, Yan Qin, Yuying Li, Jiahan Gang, Xinyu Zhang, Lulu Xie, Yimin Zhou, Qiaoqiong Wang, Wei Chen, Yuanze Sun, Zaijuan Zhang, Xianfu Ke, Tian Lan, Wenchao Sun   +14 more
doaj   +2 more sources

Epitope Mapping and Cellular Localization of Swine Acute Diarrhea Syndrome Coronavirus Nucleocapsid Protein Using a Novel Monoclonal Antibody [PDF]

Virus Research, 2019
A swine acute diarrhea syndrome coronavirus (SADS-CoV) that causes severe diarrhea in suckling piglets was identified in Southern China in 2017. To develop an antigen that is specific, sensitive, and easy to prepare for serological diagnosis, antigenic sites in the SADS-CoV nucleocapsid (N) protein were screened.
Jianfei Chen, Zhaoyang Jing, Hongyan Shi
exaly   +4 more sources

Swine acute diarrhea syndrome coronavirus nucleocapsid protein antagonizes the IFN response through inhibiting TRIM25 oligomerization and functional activation of RIG-I/TRIM25 [PDF]

Veterinary Research
Swine acute diarrhea syndrome coronavirus (SADS-CoV), an emerging Alpha-coronavirus, brings huge economic loss in swine industry. Interferons (IFNs) participate in a frontline antiviral defense mechanism triggering the activation of numerous downstream ...
Jiyu Zhang, Hongyan Shi, Liaoyuan Zhang, Tingshuai Feng, Jianfei Chen, Xin Zhang, Zhaoyang Ji, Zhaoyang Jing, Xiaoyuan Zhu, Dakai Liu, Xiaoman Yang, Miaomiao Zeng, Da Shi, Li Feng   +13 more
doaj   +2 more sources

Bat-Origin Swine Acute Diarrhea Syndrome Coronavirus Is Lethal to Neonatal Mice. [PDF]

J Virol, 2023
SADS-CoV is the documented spillover of a bat coronavirus that causes severe disease in pigs. Pigs are in frequent contact with both humans and other animals and theoretically possess a greater chance, compared to many other species, of promoting cross-species viral transmission.
Duan Y, Yuan C, Suo X, Li Y, Shi L, Cao L, Kong X, Zhang Y, Zheng H, Wang Q.   +9 more
europepmc   +3 more sources

Comprehensive Subcellular Localization of Swine Acute Diarrhea Syndrome Coronavirus Proteins. [PDF]

J Virol, 2022
SADS-CoV is the first documented spillover of a bat coronavirus that causes severe diseases in domestic animals. Our study is an in-depth annotation of the newly discovered swine coronavirus SADS-CoV genome and viral protein expression.
Yuan C, Suo X, Duan Y, Li X, Shi L, Cao L, Kong X, Zheng H, Wang Q.   +8 more
europepmc   +3 more sources

Lethal Swine Acute Diarrhea Syndrome Coronavirus Infection in Suckling Mice. [PDF]

J Virol, 2022
SADS-CoV, which likely has originated from bat coronaviruses, is highly pathogenic to piglets and poses a threat to the swine industry. Little is known about its potential to disseminate to other animals.
Chen Y, Jiang RD, Wang Q, Luo Y, Liu MQ, Zhu Y, Liu X, He YT, Zhou P, Yang XL, Shi ZL.   +10 more
europepmc   +3 more sources

Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

Nature Communications
Cepharanthine is a secondary metabolite isolated from Stephania. It has been reported that it has anti-conronaviruses activities including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen   +27 more
doaj   +2 more sources

N-linked glycoproteins and host proteases are involved in swine acute diarrhea syndrome coronavirus entry. [PDF]

J Virol, 2023
ABSTRACT Swine acute diarrhea syndrome coronavirus (SADS-CoV) is highly pathogenic to piglets and poses a major threat to the swine industry. SADS-CoV has a wide cell tropism and pathogenic potential in younger animals. Therefore, understanding how SADS-CoV enters cells is essential for curbing its re-emergence and spread.
Chen Y, Liu X, Zheng J-N, Yang L-J, Luo Y, Yao Y-L, Liu M-Q, Xie T-t, Lin H-F, He Y-T, Zhou P, Hu B, Tian R-J, Shi Z-L.   +13 more
europepmc   +3 more sources