Results 1 to 10 of about 6,592 (133)

Expression and Purification of a PEDV-Neutralizing Antibody and Its Functional Verification

Viruses, 2021
Porcine epidemic diarrhea virus (PEDV) is a highly infectious and pathogenic virus causing high morbidity and mortality, especially in newborn piglets. There remain problems with contemporary PEDV vaccines, in part because of the rapid variation of PEDV,
Qiuyan Li, Xingbo Zhao, Mengran Li
exaly   +3 more sources

Novel Neutralizing Epitope of PEDV S1 Protein Identified by IgM Monoclonal Antibody

Viruses, 2022
Porcine epidemic diarrhea virus (PEDV) causes devastating enteric disease that inflicts huge economic damage on the swine industry worldwide. A safe and highly effective PEDV vaccine that contains only the virus-neutralizing epitopes (not enhancing ...
Porntippa Lekcharoensuk, Wanpen Chaicumpa, Rungrueang Yodsheewan   +2 more
exaly   +3 more sources

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure-Enabled Lateral Flow Assay. [PDF]

Adv Healthc Mater
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Umrao S, Naru A, Gandavadi D, Zheng M, Lanka S, Cho H, Hoang CNM, Zhang J, Fang Y, Wang X.   +9 more
europepmc   +2 more sources

Genetic Diversity, Recombination, and Pathogenicity of Porcine Epidemic Diarrhea Virus Strains Circulating in China During 2023-2024. [PDF]

Transbound Emerg Dis
Porcine epidemic diarrhea virus (PEDV) is an enteric alphacoronavirus that causes severe diarrhea and high mortality in neonatal piglets, posing a persistent threat to the global swine industry. Despite extensive vaccination, PEDV continues to circulate in China, underscoring the need for updated molecular epidemiological surveillance.
Cao Y, Cui A, Chen X, Cheng Y, Tang R, Zeng H, Li Y, Yang Q.   +7 more
europepmc   +2 more sources

Fangchinoline (2021-2026): A Multitarget Bisbenzylisoquinoline Alkaloid With Emerging Anti-Infective Potential. [PDF]

J Trop Med
Background Fangchinoline (FC) is a bisbenzylisoquinoline alkaloid reported mainly from the traditional Chinese medicinal plant, Stephania tetrandra. FC has garnered scientific attention because of its wide‐ranging biological properties and multitargeted mechanisms of action.
Sirwi A, Mohamed HM, Mohamed GA, Eid BG, Abdallah HM, Ibrahim SRM.   +5 more
europepmc   +2 more sources

PEDV-Spike-Protein-Expressing mRNA Vaccine Protects Piglets Against PEDV Challenge.

MBio
Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus, causes severe diarrhea in neonatal piglets, which is associated with a high mortality rate.
Baochao Fan, Lixiang Zhao, Tianyi Zhong
exaly   +3 more sources

Resistance of Field-Isolated Porcine Epidemic Diarrhea Virus to Interferon and Neutralizing Antibody

Veterinary Sciences, 2022
Variant porcine epidemic diarrhea virus (PEDV), belonging to the genogroup G2b, has higher pathogenicity and mortality than classical PEDV, belonging to the genogroup G1a.
Jung-Eun Park, Hyun-Jin Shin
doaj   +1 more source

Immunization with porcine epidemic diarrhea virus harbouring Fc domain of IgG enhances antibody production in pigs

Veterinary Quarterly, 2020
Background Outbreaks of porcine epidemic diarrhea virus (PEDV) infection have re-emerged and spread rapidly worldwide, resulting in significant economic losses. Vaccination is the best way to prevent PEDV infection in young piglets.
Jung-Eun Park, Hyun Jang, Ju-Hun Kim, Bang-Hun Hyun, Hyun-Jin Shin   +4 more
doaj   +1 more source

Porcine Epidemic Diarrhea Virus (PEDV) ORF3 Enhances Viral Proliferation by Inhibiting Apoptosis of Infected Cells

Viruses, 2020
The genomes of coronaviruses carry accessory genes known to be associated with viral virulence. The single accessory gene of porcine epidemic diarrhea virus (PEDV), ORF3, is dispensable for virus replication in vitro, while viral mutants carrying ORF3 ...
Fusheng Si, Xiaoxia Hu, Chenyang Wang, Bingqing Chen, Ruiyang Wang, Shijuan Dong, Ruisong Yu, Zhen Li   +7 more
doaj   +1 more source

Porcine Epidemic Diarrhea Virus Envelope Protein Blocks SLA-DR Expression in Barrow-Derived Dendritic Cells by Inhibiting Promoters Activation

Frontiers in Immunology, 2021
Porcine epidemic diarrhea (PED) is an acute, highly contagious intestinal swine disease caused by porcine epidemic diarrhea virus (PEDV). In addition to known PEDV infection targets (villous small intestinal epithelial cells), recent reports suggest that
Jie Wang, Jie Wang, Yajing Wang, Yajing Wang, Bing Liu, Bing Liu, Yunwei He, Yunwei He, Zhiwei Li, Zhiwei Li, Qin Zhao, Qin Zhao, Yuchen Nan, Yuchen Nan, Chunyan Wu, Chunyan Wu   +15 more
doaj   +1 more source