Results 41 to 50 of about 10,162 (212)

Fangchinoline inhibits the PEDV replication in intestinal epithelial cells via autophagic flux suppression

Frontiers in Microbiology, 2023
Animal and human health are severely threatened by coronaviruses. The enteropathogenic coronavirus, porcine epidemic diarrhea virus (PEDV), is highly contagious, leading to porcine epidemic diarrhea (PED), which causes large economic losses in the world ...
Weixiao Zhang, Weixiao Zhang, Haiyan Shen, Haiyan Shen, Menglu Wang, Menglu Wang, Xuelei Fan, Xuelei Fan, Songqi Wang, Songqi Wang, Nile Wuri, Nile Wuri, Bin Zhang, Bin Zhang, Haiyan He, Haiyan He, Chunhong Zhang, Chunhong Zhang, Zhicheng Liu, Zhicheng Liu, Ming Liao, Ming Liao, Jianfeng Zhang, Jianfeng Zhang, Yugu Li, Jianmin Zhang   +25 more
doaj   +1 more source

Proof-of-concept method to sanitize a feed mill contaminated with Porcine Epidemic Diarrhea Virus [PDF]

, 2016
Citation: Huss, A. R., Schumacher, L. L., Cochrane, R. A., Poulsen, E., Bai, J. F., Woodworth, J. C., . . . Jones, C. K. (2016). Proof-of-concept method to sanitize a feed mill contaminated with Porcine Epidemic Diarrhea Virus. Journal of Animal Science,
Bai, Jianfa, Cochrane, R. A., Dritz, Steven S., Huss, A. R., Jones, Cassandra K., Poulsen, E., Schumacher, L. L., Stark, Charles R., Woodworth, Jason C.   +8 more
core   +1 more source

Synthetic surfactin analogues have improved anti-PEDV properties

PLOS ONE, 2019
Surfactin has antiviral activity against various enveloped viruses by inhibiting viral membrane fusion. However, the potential utility of surfactin as an antiviral drug is limited by its cytotoxicity. In this study, 10 surfactin analogues were obtained by chemical synthesis and evaluated to determine their anti-PEDV activities, hemolytic activities ...
Lvfeng Yuan, Shuai Zhang, Jie Peng, Yuchen Li, Qian Yang   +4 more
openaire   +3 more sources

Oral Immunization against PEDV with Recombinant Lactobacillus casei Expressing Dendritic Cell-Targeting Peptide Fusing COE Protein of PEDV in Piglets [PDF]

Viruses, 2018
Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our previous study, a genetically engineered Lactobacillus casei oral vaccine (pPG-COE-DCpep/L393) expressing a dendritic cell (DC)-targeting peptide fused with porcine epidemic diarrhea virus (PEDV) COE antigen was developed.
Xingyu Hou, Xinpeng Jiang, Yanping Jiang, Lijie Tang, Yigang Xu, Xinyuan Qiao, Min Liu, Wen Cui, Guangpeng Ma, Yijing Li   +9 more
openaire   +3 more sources

Analysis of Swine Conventional Dendritic Cells, DEC205⁺CD172a^+/−CADM1⁺, from Blood and Spleen in Response to PRRSV and PEDV

Viruses, 2019
Conventional dendritic cells (cDCs) cannot be infected by porcine reproductive and respiratory syndrome virus (PRRSV) but respond to infection via cytokine production, indicating a possible role in initiation/regulation of the immune response against ...
Héctor Parra-Sánchez, Lorena Bustamante-Córdova, Mónica Reséndiz, Verónica Mata-Haro, Araceli Pinelli-Saavedra, Jesús Hernández   +5 more
doaj   +1 more source

Preparation and characterisation of monoclonal antibodies against the N protein of the SHpd/2012 strain of porcine epidemic diarrhoea virus

Veterinární Medicína, 2018
Porcine epidemic diarrhoea is caused by the porcine epidemic diarrhoea virus, and is a highly contagious disease which affects the intestines of new-born piglets resulting in intense diarrhoea.
S.J. Ding, Y.R. Luo, S.T. Zhou, C. Xie, K. Wang, Y.Y. Xie, L. Cui, X.G. Hua, C.L. Yuan, Y.J. Zhou, Z.B. Yang   +10 more
doaj   +1 more source

Selective protease inhibitors from secondary metabolites of Philippine medicinal plants against porcine epidemic diarrhea virus: A computational veterinary drug discovery approach

Open Veterinary Journal
Background: Porcine epidemic diarrhea virus (PEDV) is a recurring coronavirus that causes severe diarrhea in pigs with high mortality and morbidity rates, especially in neonatal pigs. Despite the availability of vaccines, their efficacy is limited owing
John Christian C. de Guzman, Albert Neil G. Dulay, Fredmoore L. Orosco   +2 more
doaj   +1 more source

Investigation of the Role of the Spike Protein in Reversing the Virulence of the Highly Virulent Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strains and Its Attenuated Counterpart

Viruses, 2019
Porcine epidemic diarrhea virus (PEDV) has continuously caused severe economic losses to the global swine industries; however, no successful vaccine against PEDV has been developed.
Chi-Fei Kao, Hui-Wen Chang
doaj   +1 more source

RNASEK interacting with PEDV structural proteins facilitates virus entry via clathrin-mediated endocytosis

Journal of Virology
Porcine epidemic diarrhea virus (PEDV), as a type of Alphacoronavirus causing acute diarrhea and high death rate among sucking piglets, poses great financial damage to the swine industry.
Wenzhen Qin, Ning Kong, Shengsong Xie, Hailong Liu, Xinyu Yang, Yahe Wang, Xinyu Cao, Yuchang Liu, Jiarui Wang, He Sun, Wu Tong, Hai Yu, Hao Zheng, Wen Zhang, Guangzhi Tong, Tongling Shan   +15 more
doaj   +1 more source

The enhanced replication of an S-intact PEDV during coinfection with an S1 NTD-del PEDV in piglets

Veterinary Microbiology, 2019
Porcine epidemic diarrhea virus (PEDV) variants having a large deletion in the N-terminal domain of the S1 subunit of spike (S) protein were designated as S1 NTD-del PEDVs. They replicate well in experimentally infected pigs. However, on farms they often co-infect pigs with the PEDV containing an intact S protein (S-intact PEDV).
Su, Yunfang, Hou, Yixuan, Wang, Qiuhong
openaire   +2 more sources