Results 61 to 70 of about 6,592 (133)

Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation

Virus Research
ACE2 has been confirmed to be a functional receptor for SARS-CoV and SARS-CoV-2, but research on animal coronaviruses, especially PEDV, are still unknown.
Zhiqiang Li, Xueqing Chen, Chang Ma, Xinyu Du, Yuanshu Zhang   +4 more
doaj   +1 more source

Cav1.2 facilitates the binding and internalisation of porcine epidemic diarrhoea virus

Veterinary Research
Porcine epidemic diarrhoea virus (PEDV) has caused substantial economic losses to the global swine industry. The PEDV spike (S) protein mediates viral entry by interacting with host receptors.
Xinxin Wang, Guilan Guo, Shutong He, Kaili Wang, Jianing Chen, Guijie Guo   +5 more
doaj   +1 more source

Leucine Mitigates Porcine Epidemic Diarrhea Virus-Induced Colonic Damage in Piglets via Suppression of Viral Replication and Restoration of Intestinal Homeostasis

Agriculture
The preventive effect of leucine (Leu) against colonic damage in piglets infected with porcine epidemic diarrhea virus (PEDV) was examined in this study. Three groups (n = 6) were randomly assigned to eighteen 7-day-old Du-roc × Landrace × Large piglets (
Muzi Li, Lingling Gan, Jiaxing Wang, Zongyun Li, Zhonghua Li, Lei Wang, Di Zhao, Tao Wu, Dan Yi, Yanyan Zhang, Yongqing Hou   +10 more
doaj   +1 more source

Engineering a TGEV S-trimer chimera with PEDV D0-NTD generates potent neutralizing antibodies against both viruses

Journal of Virology
Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV), two economically devastating swine enteric coronaviruses, persistently threaten global pork production via severe clinical morbidity. Vaccination is the most effective
Ding Zhang, Yang Yuan, Guangli Hu, Yunfei Xie, Xiumei Meng, ZhaoTian Zhang, Yu Zhang, Qi Liao, Ashenafi Assefa Gebremariam, Hanqin Shen, Guiqing Peng, Yuejun Shi   +11 more
doaj   +1 more source

Exosomal ssc-miR-1343 targets FAM131C to regulate porcine epidemic diarrhea virus infection in pigs

Veterinary Research
The porcine epidemic diarrhea virus (PEDV) causes diarrhea in piglets, thereby causing very significant economic losses for the global swine industry.
Weiyun Qin, Jing Jiang, Jiayun Wu, Yunxiao Xie, Zhengchang Wu, Mingan Sun, Wenbin Bao   +6 more
doaj   +1 more source

Comparison of B cells' immune response induced by PEDV virulent and attenuated strains

Frontiers in Microbiology
Porcine epidemic diarrhea virus (PEDV) is an acute, highly contagious enterovirus that infects pigs of all ages. The B cells are important for antigen presentation, antibody production, and cytokine secretion to resist infection.
Chen Yuan, Chen Yuan, Xue Zhao, Xue Zhao, Yawen Feng, Ligong Chen, Ligong Chen, Yidan Lin, Yidan Lin, Tanqing Li, Tanqing Li, Qinye Song, Qinye Song   +12 more
doaj   +1 more source

Distinguished Loop-Mediated Isothermal Amplification Assay to Detect Porcine Epidemic Diarrhea Virus Genotypes I and II

Veterinary Sciences
Porcine epidemic diarrhea virus (PEDV), a primary pathogen causing diarrhea in pigs, particularly in piglets, has a mortality rate of up to 100%. Field PEDV strains circulating in pig production can be phylogenetically divided into two genotypes, GI and ...
Zhong Liu, Lanlan Li, Mengtao Fang, Xiaoqing Wei, Jieqiong Li, Qi Wu, Xiaoxue Yang, Yu Ye, Gen Wan, Dongyan Huang, Deping Song   +10 more
doaj   +1 more source

A monoclonal antibody-based electrochemical immunosensor for porcine epidemic diarrhea virus

Applied Microbiology and Biotechnology
This study reports the development of a novel and highly sensitive electrochemical immunosensor for detecting porcine epidemic diarrhea virus (PEDV). To this end, a unique PEDV spike protein–specific monoclonal antibody (mAb) was generated and evaluated ...
Wenjie Li, Jing Wang, Tao Zhang, Yuguang Fu, Baoyu Li, Guangliang Liu   +5 more
doaj   +1 more source

Recombinant AAV vaccine expressing PEDV S1 enhances immunity with superior neonatal protection

npj Vaccines
To address suboptimal antibody induction by commercial PEDV vaccines, we constructed a recombinant adeno-associated virus (rAAV-CMV-PEDV S1) expressing regions of the PEDV S1 subunit based on Adeno-associated virus serotype 2 (AAV-2) vector.
Maonan Pang, Meishen Ren, Dike Jiang, Teng Tu, You Zhou, Yin Wang   +5 more
doaj   +1 more source

Inhibitory Effect of Muscone on Porcine Epidemic Diarrhea Virus In Vitro. [PDF]

Viruses
Guan S, Jian Y, Zhang L, Lv Z, Hu R, Wu H, Xie H, Song D, Ding Z, Chen Z.   +9 more
europepmc   +1 more source