Results 71 to 80 of about 2,971,207 (141)

In vitro and in vivo expression of foreign genes by transmissible gastroenteritis coronavirus-derived minigenomes [PDF]

, 2002
A helper-dependent expression system based on transmissible gastroenteritis coronavirus (TGEV) has been developed using a minigenome of 3·9 kb (M39).
Enjuanes, L., Plana-Duran, J., Reimann, I., Moormann, R.J.M., Sola, I., Plana Duran, J., Alonso, S., Izeta, A., Teifke, J.P., Teifke, Jens Peter, Reimann, Ilona, Balasch, M.   +11 more
core   +1 more source

A Quadruplex qRT-PCR for Differential Detection of Four Porcine Enteric Coronaviruses

Veterinary Sciences, 2022
Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine deltacoronavirus (PDCoV), and swine acute diarrhea syndrome coronavirus (SADS-CoV) are four identified porcine enteric coronaviruses.
Hongjin Zhou, Kaichuang Shi, Feng Long, Kang Zhao, Shuping Feng, Yanwen Yin, Chenyong Xiong, Sujie Qu, Wenjun Lu, Zongqiang Li   +9 more
doaj   +1 more source

The SARS-coronavirus-host interactome [PDF]

, 2011
Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to ...
Brunn, Albrecht von, Steffen, Imke, Kögl, Manfred, Schwegmann-Wessels, Christel, Pumpor, Ksenia, Müller, Marcel A., Herzog, Petra, Kuri, Thomas, Ditt, Vanessa, Weber, Friedemann, Schwarz, Frank, Pfefferle, Susanne, Schöpf, Julia, Kallies, Stefan, Herrler, Georg, Carbajo-Lozoya, Javier, Zimmer, Ralf, Hilgenfeld, Rolf, Friedel, Caroline C., Dall'Armi, Ekatarina von, Drosten, Christian, Niemeyer, Daniela, Thiel, Volker, Züst, Roland, Stellberger, Thorsten, Thiel, Heinz-Jürgen, Pöhlmann, Stefan, Haas, Juergen G.   +27 more
core   +1 more source

Swine acute diarrhea syndrome coronavirus Nsp1 suppresses IFN-λ1 production by degrading IRF1 via ubiquitin-proteasome pathway. [PDF]

Vet Res
AbstractSwine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel porcine enteric coronavirus that causes acute watery diarrhea, vomiting, and dehydration in newborn piglets. The type III interferon (IFN-λ) response serves as the primary defense against viruses that replicate in intestinal epithelial cells.
Zhong C, She G, Zhao Y, Liu Y, Li J, Wei X, Chen Z, Zhao K, Zhao Z, Xu Z, Zhang H, Cao Y, Xue C.   +12 more
europepmc   +5 more sources

Cryo-electron Microscopy Structure of the Swine Acute Diarrhea Syndrome Coronavirus Spike Glycoprotein Provides Insights into Evolution of Unique Coronavirus Spike Proteins. [PDF]

J Virol, 2020
In this article, we report the atomic-resolution prefusion structure of the spike protein from swine acute diarrhea syndrome coronavirus (SADS-CoV). SADS-CoV is a pathogenic alphacoronavirus that was responsible for a large-scale outbreak of fatal disease in pigs and that was reported to be capable of interspecies transmission.
Guan H, Wang Y, Perčulija V, Saeed AFUH, Liu Y, Li J, Jan SS, Li Y, Zhu P, Ouyang S.   +9 more
europepmc   +4 more sources

Epidemiological and genetic analysis of severe acute respiratory syndrome.

, 2004
The severe acute respiratory syndrome (SARS) epidemics in 2002-2003 showed how quickly a novel infectious disease can spread both within communities and internationally.
Fisher, Matthew C, Donnelly, CA, Fisher, MC, Ghani, Azra C, Anderson, Roy M, Ferguson, NM, Riley, Steven, Ghani, AC, Anderson, RM, Donnelly, Christl A, Riley, S, Ferguson, Neil M, Fraser, C, Fraser, Christophe   +13 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure‐Enabled Lateral Flow Assay

Advanced Healthcare Materials, Volume 15, Issue 26, 10 July 2026.
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao, Akhila Naru, Dhanush Gandavadi, Mengxi Zheng, Saraswathi Lanka, Hyeongjun Cho, Chau Nguyen Minh Hoang, Jianqiang Zhang, Ying Fang, Xing Wang   +9 more
wiley   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source