Results 41 to 50 of about 3,566 (133)
The Journal of Clinical Hypertension, 2021 Hypertension is a worldwide epidemic that continues to grow, with a subset of patients responding poorly to current treatment available. This is especially relevant in Asia, which constitutes 61% of the global population. Hypertension in Asia is a unique
Donna S.‐H. Lin +12 more
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Concurrent Use of Tasipimidine Oral Solution and Clomipramine in Dogs
Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 6, Page 457-467, November 2025.ABSTRACT The study evaluated pharmacokinetics, effects on functional alertness, and cardiovascular parameters of tasipimidine oral solution (Tessie, Orion Corporation) alone and in combination with oral clomipramine in six healthy laboratory dogs. Pharmacokinetics and functional alertness were studied after a single dose (Phase 1) and after 4 days of ...
Jenni Maria Lindstedt +4 more
wiley +1 more source
Intramural Blood Vessels as a Primary Site of Vascular LUTS
LUTS: Lower Urinary Tract Symptoms, Volume 17, Issue 6, November 2025.ABSTRACT Ischaemia has been considered a primary cause of lower urinary tract symptoms (LUTS). The existing concept is that ischaemic LUTS develops subsequent to structural narrowing of feeder arteries of the LUT due to atherosclerosis. However, the distribution of blood flow within each LUT organ that is regulated by intramural microvasculature should
Hikaru Hashitani, Retsu Mitsui
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Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats
Mediators of Inflammation, 2020 Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic ...
Naren Bao, Di Dai
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British Journal of Pharmacology, Volume 182, Issue 19, Page 4535-4552, October 2025.Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira +1 more
wiley +1 more source
Analgesic efficacy of stellate ganglion block in head and neck cancer pain: A case series
Journal of Family Medicine and Primary CarePatients with head and neck cancer (HNC) have ongoing pain but Stellate ganglion block which is a sympatholytic block may be a viable therapy for treating it.
Seerat Chiraya +3 more
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Benefits of using dexmedetomidine during carotid endarterectomy: A review
Saudi Journal of Anaesthesia, 2014 As per current recommendation, patients with acute ischemic stroke should be offered carotid endarterectomy (CEA) within 24-72 hours. The same applies to patients with recurrent transient ischemic attacks (TIA).
Abhijit S Nair
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Iatrogenic pulsus alternans in a dog undergoing median sternotomy
Veterinary Record Case Reports, Volume 13, Issue 3, September 2025.Abstract A 6‐year‐old, 21.8 kg, female, spayed Siberian husky was referred for management of a spontaneous bilateral pneumothorax, due to a ruptured pulmonary bleb. During surgery, sterile saline was instilled on three occasions in order to locate the damaged lung tissue and ensure complete ligation.
Marie‐Line Doï +2 more
wiley +1 more source
BMC Pharmacology and Toxicology, 2018 Background Clonidine is an imidazoline sympatholytic, acting on both α2-adrenergic and imidazoline receptors in the brainstem to induce antihypertensive and negative chronotropic effects in the vasculature and heart respectively.
Alexander J. Sandweiss +3 more
doaj +1 more source