Results 221 to 230 of about 269,638 (309)

Co-delivery of synaptogenic and angiogenic nanoparticles in MAP scaffolds enhances post-stroke synapse formation.

J Mater Chem B
Phan NV, Thomas JL, Pasinsky A, Meadows Z, Li TT, Adams A, Zhu Y, Edgcomb A, Shi Y, Lyu S, Dunn TW, Segura T.   +11 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Transcriptomic analysis reveals synaptic dysregulation and mitochondrial dysfunction in autism spectrum disorder. [PDF]

Brain Behav Immun Health
Liao X, Shao J, Chen Z.
europepmc   +1 more source

Developmental Changes in Synaptic Function in a Giant Auditory Synapse

, 2016
Tom Crins
openalex   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Spike-based Q-learning in a non-von Neumann architecture. [PDF]

Front Neurosci
Shin D, Jo H, Jang H, Jeong YH, Jeong Y, Kwak JY, Park J, Lee S, Kim I, Park JK, Park S, Jang HJ, Lee HM, Kim J.   +13 more
europepmc   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

SynaptopathyDB integrates synaptic proteomes, genetic and phenotypic data to advance research on nervous system disorders. [PDF]

Sci Rep
Sorokina O, Dominic D, Bayés À, Armstrong JD, Grant SGN.   +4 more
europepmc   +1 more source

Time‐Resolved SAXS Reveals Distinct Millisecond Metal‐Induced Conformational Dynamics of Monomeric α‐Synuclein

Advanced Science, EarlyView.
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo   +3 more
wiley   +1 more source

Profiling presynaptic scaffolds using split-GFP reconstitution reveals cell-type-specific spatial configurations in the fly brain. [PDF]

Elife
Wu H, Maekawa Y, Eno S, Kondo S, Yamagata N, Tanimoto H.   +5 more
europepmc   +1 more source