Results 81 to 90 of about 531,184 (380)

GeNN: a code generation framework for accelerated brain simulations [PDF]

, 2015
Large-scale numerical simulations of detailed brain circuit models are important for identifying hypotheses on brain functions and testing their consistency and plausibility. An ongoing challenge for simulating realistic models is, however, computational
AJ Cope, C Rossant, DF Goodman, DF Goodman, E Ros, EM Izhikevich, EM Izhikevich, HÜ Dinkelbach, I Raikov, J Baladron, JM Nageswaran, MA Swertz, ML Hines, NF Rulkov, P Gleeson, R Brette, SC Eisenstat, T Nowotny, T Nowotny, VK Pallipuram   +19 more
core   +1 more source

Neuron-Glia Signaling in Synapse Elimination.

Annual Review of Neuroscience, 2019
Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role.
D. Wilton, Lasse Dissing‐Olesen, B. Stevens   +2 more
semanticscholar   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse

Scientific Reports, 2021
Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion reaction–diffusion events within nerve terminals leading to vesicular release of neurotransmitter.
Maria Reva, David A. DiGregorio, Denis S. Grebenkov   +2 more
doaj   +1 more source

Optically Stimulated Artificial Synapse Based on Layered Black Phosphorus.

Small, 2019
The translation of biological synapses onto a hardware platform is an important step toward the realization of brain-inspired electronics. However, to mimic biological synapses, devices till-date continue to rely on the need for simultaneously altering ...
Taimur Ahmed, Sruthi Kuriakose, E. Mayes, R. Ramanathan, V. Bansal, M. Bhaskaran, S. Sriram, S. Walia   +7 more
semanticscholar   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development

Frontiers in Cellular Neuroscience, 2019
In the adult brain GABAA receptors (GABAARs) mediate the majority of synaptic inhibition that provides inhibitory balance to excitatory drive and controls neuronal output.
Jingjing Duan, Jingjing Duan, Saurabh Pandey, Tianming Li, David Castellano, Xinglong Gu, Jun Li, Qingjun Tian, Wei Lu   +8 more
doaj   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Thrombin generation remains stable in frozen plasma over long-term storage

Thrombosis Update
Background: The ST Genesia is a fully automated thrombin generation (TG) device. Measuring TG can be useful for medical purposes as it is an indicator for the bleeding or thrombotic risk of a patient.
A. Carlo, R. de Laat-Kremers, B. de Laat, M. Ninivaggi   +3 more
doaj   +1 more source