Results 91 to 100 of about 352,422 (329)
eLife, 2016 The mechanisms regulating synapse numbers during development and ageing are essential for normal brain function and closely linked to brain disorders including dementias. Using Drosophila, we demonstrate roles of the microtubule-associated protein Tau in
Andre Voelzmann +6 more
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Advanced Healthcare Materials, EarlyView.Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee +9 more
wiley +1 more source
The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders
Neuropsychiatric Disease and Treatment, 2023 Xiaoshan Ye,1,* Qionglin Zhou,2,* Pengcheng Ren,1,3,4 Wei Xiang,1,3 Le Xiao1 1Hainan Women and Children’s Medical Center, School of Pediatrics, Hainan Medical University, Haikou, People’s Republic of China; 2International School of Public Health ...
Ye X, Zhou Q, Ren P, Xiang W, Xiao L
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Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
Frontiers in Cellular Neuroscience, 2020 Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease ...
Catarina Perdigão +5 more
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Gauge Symmetry and Neural Networks
, 2001 We propose a new model of neural network. It consists of spin variables to describe the state of neurons as in the Hopfield model and new gauge variables to describe the state of synapses.
Matsui, Tetsuo
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Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma
Advanced Healthcare Materials, EarlyView.A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li +8 more
wiley +1 more source
Challenges and Opportunities of Upconversion Nanoparticles for Emerging NIR Optoelectronic Devices
Advanced Materials, EarlyView.The special photo‐responsiveness of upconversion nanoparticles has opened up a new path for the advancement of near‐infrared (NIR)‐responsive optoelectronics. However, challenges such as low energy‐conversion efficiency and high nonradiative losses still persist.
Sunyingyue Geng +7 more
wiley +1 more source
, 2016 Synaptic memory is considered to be the main element responsible for learning and cognition in humans. Although traditionally non-volatile long-term plasticity changes have been implemented in nanoelectronic synapses for neuromorphic applications, recent
Roy, Kaushik, Sengupta, Abhronil
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Synergies at the synapse [PDF]
British Journal of Pharmacology, 2003 British Journal of Pharmacology (2003) 138, 1387–1388.
openaire +3 more sources
Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics
Advanced Materials, EarlyView.Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi +4 more
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