Results 151 to 160 of about 2,578,136 (352)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The alpha-latrotoxin mutant LTXN4C enhances spontaneous and evoked transmitter release in CA3 pyramidal neurons

, 2003
Alpha-latrotoxin (LTX) stimulates vesicular exocytosis by at least two mechanisms that include (1) receptor binding-stimulation and (2) membrane pore formation.
Emptage, NJ, Ushkaryov, YA, Capogna, M, Capogna, Marco, Volynski, KE   +4 more
core  

Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors.

Biochemical Journal, 1982
I. S. Fulcher, R. Matsas, A. Turner, A. Kenny   +3 more
semanticscholar   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Mobility of Synaptic Vesicles in Nerve Endings Monitored by Recovery from Photobleaching of Synaptic Vesicle-Associated Fluorescence

, 1996
In nerve terminals, synaptic vesicles form large clusters anchored to the presynaptic plasmalemma. Recently, FM1-43 photobleaching experiments carried out at frog motor endplates demonstrated lack of lateral intermixing of synaptic vesicles within ...
Pietro De Camilli, Laurie Daniell, Kajetan Kraszewski, Olaf Mundigl   +3 more
core   +1 more source

Purification of an endogenous protein inhibitor of the high affinity binding of gamma-aminobutyric acid to synaptic membranes of rat brain.

Proceedings of the National Academy of Sciences of the United States of America, 1978
G. Toffano, A. Guidotti, E. Costa
semanticscholar   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.

Proceedings of the National Academy of Sciences of the United States of America, 1983
R. Matsas, I. S. Fulcher, A. Kenny, A. Turner   +3 more
semanticscholar   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

2D Copper MOF Membranes with Precise Pores for Ionic Memory

Advanced Science
Biological ion channels play a critical role in the complex physiological processes of living organisms. Inspired by these natural systems, we demonstrate the fabrication of ultrathin 2D copper‐based metal‐organic framework (CuMOF) films and their ...
Hiran Jyothilal, Raj Kumar Gogoi, Yuchen Liu, Vikas Sharma, Solleti Goutham, Michael Hutton, Rachel C. Kilbride, Daniel T.W. Toolan, Ashok Keerthi, Boya Radha   +9 more
doaj   +1 more source