Results 71 to 80 of about 2,578,136 (352)

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Synaptic Membrane Phosphorylation : Target for Neurotransmitters and Peptides [PDF]

, 1982
Publisher Summary The biochemistry of brain tissue confronts us with an enormous heterogeneity of components. In certain brain areas (corpus striaturn, thalamus, medulla oblongata) the various cell types are distributed heterogeneously and disorderly, but in other regions (cerebral cortex, cerebellum, hippocampus) a strict organization determines the
Gispen, W.H., Oestreicher, A.B., Zwiers, H.   +2 more
openaire   +3 more sources

Solution‐Processed Two‐Dimensional Indium Oxide on Sodium‐Embedded Alumina for Reconfigurable Optoelectronic Synaptic Transistors

Advanced Functional Materials, EarlyView.
Wafer‐scale two‐dimensioanl In2Se3 oxidized into InOx on sodium‐embedded beta‐alumina enables multifunctional reconfigurable electronics. Sodium ions accumulate within distinct spatial distribution under drain‐controlle and gate‐controlled operation. Drain‐control operation gives controllability of ultraviolet‐driven optoelectronic synaptic conductance
Jinhong Min, Yonghyun Albert Kwon, Hyunbin Kim, Jihyun Kim, Myeongjin Jung, Jaewon Heo, Gwang Ya Kim, Vlastimil Mazanek, Zdeněk Sofer, In Soo Kim, Jeong Ho Cho, Hyesung Park, Sang Min Won, Joohoon Kang   +13 more
wiley   +1 more source

Neuron‐Inspired Biomolecular Memcapacitors Formed Using Droplet Interface Bilayer Networks

Advanced Electronic Materials
Brain‐inspired (or neuromorphic) computing circumvents costly bottlenecks in conventional Von Neumann architectures by collocating memory and processing.
Braydon Segars, Kyle Rosenberg, Sarita Shrestha, Joshua J. Maraj, Stephen A. Sarles, Eric Freeman   +5 more
doaj   +1 more source

Forebrain deletion of αGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections.

PLoS ONE, 2012
The GDI1 gene encodes αGDI, which retrieves inactive GDP-bound RAB from membranes to form a cytosolic pool awaiting vesicular release. Mutations in GDI1 are responsible for X-linked Intellectual Disability.
Veronica Bianchi, Frédéric Gambino, Luca Muzio, Daniela Toniolo, Yann Humeau, Patrizia D'Adamo   +5 more
doaj   +1 more source

A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity

Cell Death Discovery, 2023
Synaptotoxic Aβ oligomers are thought to play a major role in the early pathology of Alzheimer´s disease (AD). However, the molecular mechanisms involved in Aβ-induced synaptic dysfunction and synapse damage remain largely unclear.
Zenghui Teng, Georgia-Ioanna Kartalou, Sushma Dagar, Patrick C. Fraering, Volkmar Lessmann, Kurt Gottmann   +5 more
doaj   +1 more source

Immune labeling and purification of a 71-kDa glutamate-binding protein from brain synaptic membranes. Possible relationship of this protein to physiologic glutamate receptors.

Journal of Biological Chemistry, 1988
Immunoblot studies of synaptic membranes isolated from rat brain using antibodies raised against a previously purified glutamate-binding protein (GBP) indicated labeling of an approximately 70-kDa protein band.
J. Chen, M. Cunningham, N. Galton, E. Michaelis   +3 more
semanticscholar   +1 more source

Spatiotemporal Drug Delivery via a Neonatal Spinal Cord ECM Hydrogel for Biomimetic Microenvironment Remodeling After Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu, Liangchao Du, Runlin Wen, Kai Zhang, Yu Zhou, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Xing Li   +8 more
wiley   +1 more source

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

Nature Communications, 2018
The Na+/H+ exchanger NHE9 is proposed to regulate the H+ electrochemical gradient across endosomal membranes. Here, the authors find that NHE9 knockout mice show autism spectrum disorder-like behaviors and disrupted synaptic vesicle exocytosis due to ...
Julie C. Ullman, Jing Yang, Michael Sullivan, Jacob Bendor, Jonathan Levy, Ellen Pham, Katlin Silm, Helia Seifikar, Vikaas S. Sohal, Roger A. Nicoll, Robert H. Edwards   +10 more
doaj   +1 more source

Effects of Synaptic Plasma Membranes on Release of Acetylcholine from Synaptic Vesicles

Japanese Journal of Pharmacology, 1978
The influences of synaptic plasma membranes on release of acetylcholine (ACh) from synaptic vesicles isolated from rat brain were examined. In the presence of ATP, Mg++ and Ca++ but absence of cytoplasm from the nerve endings, the synaptic plasma membranes did not increase ACh release indicating absence of a stimulating factor which is known to be ...
KUO, Che-Hui, ICHIDA, Seiji, HATA, Fumiaki, YOSHIDA, Hiroshi   +3 more
openaire   +3 more sources