Results 91 to 100 of about 571,868 (347)
, 2016 In this chapter we will consider two main types of plasticity. First, we will discuss short-term plasticity, the modulation of synaptic strength on the time scale of milliseconds to seconds. Second, we will learn about long-term plasticity, long-lasting changes to synaptic strength that form the basis of learning and memory.
openaire +3 more sources
Advanced Functional Materials, EarlyView.An ultra‐robust memristor based on SrTiO3‐CeO2 (S‐C) vertically aligned nanocomposite (VAN) achieving exceptional endurance of 1012 switching cycles via interface engineering. Artificial neural networks (ANNs) integrated with S‐C VAN memristors exhibit high training accuracy across multiple datasets.
Zedong Hu +12 more
wiley +1 more source
Locally coordinated synaptic plasticity of visual cortex neurons in vivo
Science, 2018 Rebalancing strength between synapses Activation of a neuronal pathway is often associated with inhibition of surrounding pathways. How locally coordinated synaptic plasticity occurs in vivo is not known, nor is its role in shaping neuronal responses. El-
Sami El-Boustani +6 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee +9 more
wiley +1 more source
Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses
The Scientific World Journal, 2002 Glutamate receptors mediate the majority of excitatory responses in the central nervous system. The establishment and refinement of glutamatergic synaptic connections depend on the concerted actions of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate ...
Elek Molnar, John T.R. Isaac
doaj +1 more source
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
Nature Communications, 2020 The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in male,
Zhi-Xiang Xu +15 more
doaj +1 more source
Mechanisms of Homeostatic Synaptic Plasticity in vivo
Frontiers in Cellular Neuroscience, 2019 Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function.
Hey-Kyoung Lee, A. Kirkwood
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho +7 more
wiley +1 more source
Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity
Frontiers in Molecular Neuroscience, 2019 Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking, localization, and protein interaction dynamics.
L. Matt +3 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li +8 more
wiley +1 more source