Results 191 to 200 of about 571,868 (347)

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

THE NEUROPHARMACOLOGY OF SYNAPTIC PLASTICITY WITHIN THE NUCLEUS ACCUMBENS

, 1998
Cyriel M. A. Pennartz, A. B. Mulder, FH. Lopes da Silva   +2 more
openalex   +1 more source

Forebrain-Specific Calcineurin Knockout Selectively Impairs Bidirectional Synaptic Plasticity and Working/Episodic-like Memory [PDF]

, 2001
Hongkui Zeng, Sumantra Chattarji, Michaela Barbarosie, Laure Rondi‐Reig, Benjamin D. Philpot, Tsuyoshi Miyakawa, Mark F. Bear, Susumu Tonegawa   +7 more
openalex   +1 more source

Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory. [PDF]

Mol Brain
Kim SY, Yoon KN, Ji J, Kim MG, Choi SA, Park G, Lee WW, Chung JH, Kim SJ, An JY, Lee DH, Lee YS.   +11 more
europepmc   +1 more source

Behavioral time scale synaptic plasticity underlies CA1 place fields

Science, 2017
Katie C. Bittner, Aaron D. Milstein, Christine Grienberger, S. Romani, J. Magee   +4 more
semanticscholar   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Synaptic plasticity: A molecular memory switch [PDF]

, 2001
John Lisman, Charmian McIntyre
openalex   +1 more source

Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Nature Communications, 2021
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor   +7 more
doaj   +1 more source

3D‐Printing of Electroconductive MXene‐Based Micro‐Meshes in a Biomimetic Hyaluronic Acid‐Based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications

Advanced Science, EarlyView.
This study combined microscale 3D‐printing with 2D Ti3C2Tx MXene nanosheets to produce electroconductive microfibrous micro‐meshes. By embedding these MXene‐functionalized micro‐meshes within a growth‐supportive macroporous extracellular matrix (ECM)‐based biomaterial, multifunctional biomimetic MXene‐ECM scaffolds were developed.
Ian Woods, Dahnan Spurling, Sandra Sunil, Anne Marie O'Callaghan, Jack Maughan, Javier Gutierrez‐Gonzalez, Tara K. McGuire, Liam Leahy, Adrian Dervan, Valeria Nicolosi, Fergal J. O'Brien   +10 more
wiley   +1 more source

Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice [PDF]

, 2001
Wojciech Krȩżel, Sonia Dupont, Andrée Krust, Pierre Chambon, Paul F. Chapman   +4 more
openalex   +1 more source