Results 211 to 220 of about 324,242 (283)

Psychedelics Reverse the Polarity of Long-Term Synaptic Plasticity in Cortical-Projecting Claustrum Neurons. [PDF]

eNeuro
Anderson TL, Asadipooya A, Ortinski PI.
europepmc   +1 more source

Synaptic plasticity in the mesolimbic system

, 2010
Billy T. Chen, F. Woodward Hopf, Antonello Bonci   +2 more
openalex   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Interactions between long- and short-term synaptic plasticity transform temporal neural representations into spatial. [PDF]

Proc Natl Acad Sci U S A
Yu Q, Tsodyks M, Sompolinsky H, Schmitz D, Gütig R.   +4 more
europepmc   +1 more source

The Regulation of Hippocampal Synaptic Plasticity by Upstream and Downstream Effectors of Histone Acetylation

, 2015
Morgan S. Bridi
openalex   +1 more source

Neuroprotective effect of β-asarone against Alzheimer’s disease: regulation of synaptic plasticity by increased expression of SYP and GluR1

, 2016
Sijun Liu, Cong Yang, Yue Zhang, Ruyu Su, Junli Chen, Mengmeng Jiao, Huifang Chen, Na Zheng, Si Luo, Yunbo Chen, Shijian Quan, Qi Wang   +11 more
openalex   +2 more sources

The mGluR5 positive allosteric modulator VU0409551 improves synaptic plasticity and memory of a mouse model of Huntington's disease [PDF]

, 2018
Juliana G. Doria, Jéssica M. de Souza, Flávia Rodrigues da Silva, Isabella G. Olmo, Toniana G. Carvalho, Juliana Alves‐Silva, Talita H. Ferreira‐Vieira, Jessica T. Santos, Claudymara Q. S. Xavier, Nathália C. Silva, Esther M. A. Maciel, Peter Jeffrey Conn, Fabíola M. Ribeiro   +12 more
openalex   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Vagus nerve stimulation modulates cocaine seeking induced synaptic plasticity in reward related brain circuits. [PDF]

Sci Rep
Arezoomandan R, Vu L, Driskill C, Kroener S.   +3 more
europepmc   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source