Results 211 to 220 of about 279,244 (245)
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Metaplasticity: the plasticity of synaptic plasticity
Trends in Neurosciences, 1996In this paper, we review experimental evidence for a novel form of persistent synaptic plasticity we call metaplasticity. Metaplasticity is induced by synaptic or cellular activity, but it is not necessarily expressed as a change in the efficacy of normal synaptic transmission.
Wickliffe C. Abraham, Mark F. Bear
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Astrocytes and Synaptic Plasticity
The Neuroscientist, 2010Synaptic plasticity, the ability of neurons to change the number and strength of their synapses, has long been considered the sole province of the neuron. Yet neurons do not function in isolation; they are a part of elaborate glial networks where they are intimately associated with astrocytes.
Barker, A., Ullian, E.
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Synaptic plasticity and addiction
Nature Reviews Neuroscience, 2007Addiction is caused, in part, by powerful and long-lasting memories of the drug experience. Relapse caused by exposure to cues associated with the drug experience is a major clinical problem that contributes to the persistence of addiction. Here we present the accumulated evidence that drugs of abuse can hijack synaptic plasticity mechanisms in key ...
Robert C. Malenka, Julie A. Kauer
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Synaptic plasticity in the subiculum
Progress in Neurobiology, 2009The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic ...
Pawel Fidzinski +3 more
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Lithium and synaptic plasticity
Bipolar Disorders, 1999Lithium, a small cation, has been used in the treatment of bipolar disorders since its introduction in the 1950s by John Cade. Extensive research on the mechanism of action of lithium has revealed several possible targets. For some time, the most widely accepted action of lithium was its inhibitory effect on the synthesis of inositol, resulting in ...
Anita C. Hall, Patricia C. Salinas
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Naturwissenschaften, 1979
Synaptic plasticity is manifested by long-lasting changes in synaptic potency. Increased potency is of special importance in relation to the neural basis of memory. Even mild repetitive stimulation evokes large and prolonged potentiations of hippocampal synapses, as is revealed by electrical recording either in vivo or in vitro.
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Synaptic plasticity is manifested by long-lasting changes in synaptic potency. Increased potency is of special importance in relation to the neural basis of memory. Even mild repetitive stimulation evokes large and prolonged potentiations of hippocampal synapses, as is revealed by electrical recording either in vivo or in vitro.
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NEUROTROPHINS AND SYNAPTIC PLASTICITY
Annual Review of Neuroscience, 1999▪ Abstract  Despite considerable evidence that neuronal activity influences the organization and function of circuits in the developing and adult brain, the molecular signals that translate activity into structural and functional changes in connections remain largely obscure.
Donald C. Lo +2 more
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Cell Calcium, 1998
A major effort in neuroscience is directed towards understanding the roles of Ca2+ signalling in the induction of synaptic plasticity. Here, we summarize the evidence concerning Ca2+ signalling, paying particular attention to CA1 excitatory synapses, and its relationship to the induction of long-term potentiation and long-term depression.
Simon Alford +2 more
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A major effort in neuroscience is directed towards understanding the roles of Ca2+ signalling in the induction of synaptic plasticity. Here, we summarize the evidence concerning Ca2+ signalling, paying particular attention to CA1 excitatory synapses, and its relationship to the induction of long-term potentiation and long-term depression.
Simon Alford +2 more
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2014
Chemical synapses are not static transmitters of information. Their effectiveness waxes and wanes depending upon factors such as the frequency of stimulation and prior activity. The ability of synapses to change their strength, called synaptic plasticity, is critical not only for regulating the flow of information within neuronal circuits, but also for
Harel Shouval +3 more
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Chemical synapses are not static transmitters of information. Their effectiveness waxes and wanes depending upon factors such as the frequency of stimulation and prior activity. The ability of synapses to change their strength, called synaptic plasticity, is critical not only for regulating the flow of information within neuronal circuits, but also for
Harel Shouval +3 more
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Synaptic Plasticity and Dysconnection in Schizophrenia
Biological Psychiatry, 2006Current pathophysiological theories of schizophrenia highlight the role of altered brain connectivity. This dysconnectivity could manifest 1) anatomically, through structural changes of association fibers at the cellular level, and/or 2) functionally, through aberrant control of synaptic plasticity at the synaptic level.
Stephan, K E, Baldeweg, T, Friston, K J
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