Results 191 to 200 of about 169,822 (259)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Comprehensive behavioral characterization and impaired hippocampal synaptic transmission in R1117X Shank3 mutant mice. [PDF]

Transl Psychiatry
Gao J, Wu S, Yang J, Ye T, Yang J, Shen W, Chen X, Huang L, Pang R, Lin P, Lin J, Zhou Y, Wang W, Tan T.   +13 more
europepmc   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Early and transient increase in cortical pyramidal cell excitability and delayed alteration of evoked synaptic transmission and t-SNARE proteins content in the hippocampus and neocortex of neonatal and juvenile <i>Stxbp1</i> heterozygous mice. [PDF]

Front Cell Neurosci
Pineau L, Brosset-Heckel M, Becq H, Pallesi-Pocachard E, Montheil A, Biba-Maazou N, Milh M, Lenck-Santini PP, Aniksztejn L.   +8 more
europepmc   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice. [PDF]

Sci Rep
Abe T, Kurabe M, Nakamura Y, Sasaki M, Seino Y, Furutani K, Ueno M, Baba H.   +7 more
europepmc   +1 more source

Ppp2r1a haploinsufficiency increases excitatory synaptic transmission and decreases spatial learning by impairing endocannabinoid signaling. [PDF]

J Clin Invest
Wang Y, Duan W, Li H, Tang Z, Cai R, Cai S, Deng G, Chen L, Luo H, Chen L, Li Y, Wang JZ, Xiong B, Jiang M.   +13 more
europepmc   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission. [PDF]

Adv Sci (Weinh)
Huang H, Zhou C, Chen C, Tang H, Dong W, Wan J, Kang W, Sun A, Liu Y, Jin C, Lyu X, Zhu Y, Zhou C, Wu Y.   +13 more
europepmc   +1 more source

Gain of Alternative Allele Expression of LINC02449 at rs149707223 in Schizophrenia and Bipolar Disorder: Inducing Synaptic Transmission and Behavioral Deficits in Mice. [PDF]

Nat Commun
Yang T, Liu JM, Chen Q, Deng Z, Ni C, Wang Y, Lan Y, Jiang T, Li S, Jiang M, Xue H, Cao X, Wang Z, Zhao C.   +13 more
europepmc   +1 more source

High frequency stimulation activates hot spots of spontaneous synaptic transmission. [PDF]

Front Synaptic Neurosci
Astacio H, Bykhovskaia M.
europepmc   +1 more source