Results 171 to 180 of about 634,741 (343)

Actomyosin-mediated inhibition of synaptic vesicle release under CB1R activation

Translational Psychiatry
Long-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic mechanisms of functional plasticity remain poorly understood.
Maureen H. McFadden, Michel-Boris Emeritt, Hao Xu, Yihui Cui, Christophe Leterrier, Diana Zala, Laurent Venance, Zsolt Lenkei   +7 more
doaj   +1 more source

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

Neuron, 2017
Y. Lai, Ucheor B Choi, J. Leitz, H. Rhee, Choongku Lee, Bekir Altas, Minglei Zhao, R. Pfuetzner, Austin L Wang, N. Brose, J. Rhee, A. Brunger   +11 more
semanticscholar   +1 more source

Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets

Pharmacological Reviews, 2017
Ying C. Li, E. Kavalali
semanticscholar   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

tDCS improves early Alzheimer's disease by synaptic vesicle fusion and release. [PDF]

Mil Med Res
Zhuang YY, Yan JM, Wu TC, Xu WS, Wu B, Xie X, Wang WJ, Lin HW, Jian JW, Wang JZ, Jiang T, Chen LM, Qiu YX, Hu ZY, Zhou YH, Yang T, Yang MG, Zhu JF, Tao J, Chen LD, Li WG, Yan K, Liu WL.   +22 more
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Selective, genetically induced increase in synaptic vesicle priming. [PDF]

Sci Adv
Aldahabi M, Balint F, Lorincz A, Lipstein N, Brose N, Nusser Z.   +5 more
europepmc   +1 more source

Neurotransmitter release: the last millisecond in the life of a synaptic vesicle.

Neuron, 2013
T. Südhof
semanticscholar   +1 more source