Results 51 to 60 of about 125,336 (300)

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

, 2019
The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored.
Bansal, V., Bonn, S., Fornasiero, E., Fritsch, E., Gomes, L., Gärtner, A., Keihani, S., Klüver, V., Kügler, S., Mandad, S., Rahman, R., Rizzoli, S., Urlaub, H., Wren, J.   +13 more
core   +1 more source

Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]

, 2016
The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni, Dallérac, Glenn, Davies, Heather A., Doyère, Valérie, Kraev, Igor V., Stewart, Michael G.   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Nonmuscle Myosin II helps regulate synaptic vesicle mobility at the Drosophila neuromuscular junction

BMC Neuroscience, 2010
Background Although the mechanistic details of the vesicle transport process from the cell body to the nerve terminal are well described, the mechanisms underlying vesicle traffic within nerve terminal boutons is relatively unknown.
Qiu Xinping, Seabrooke Sara, Stewart Bryan A   +2 more
doaj   +1 more source

Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles [PDF]

, 2018
Available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.Peer reviewedPublisher ...
Bewick, Guy Smith, Lomo, T., Martinov, V. N., Nja, A., Reid, Brian   +4 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. [PDF]

, 2018
Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood.
Bendor, Jacob, Edwards, Robert H, Levy, Jonathan, Nicoll, Roger A, Pham, Ellen, Seifikar, Helia, Silm, Katlin, Sohal, Vikaas S, Sullivan, Michael, Ullman, Julie C, Yang, Jing   +10 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer. [PDF]

PLoS Computational Biology, 2012
Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are
Robert Rosenbaum, Jonathan Rubin, Brent Doiron   +2 more
doaj   +1 more source

Synaptic vesicle proteins

Current Biology, 1999
Thomas Sudhof, Pietro De Camilli, Reinhard Jahn and Richard Scheller, to name but a few. Although the competitive, fast-paced nature of the field means you're unlikely to find them all in the same room at the same time.
openaire   +2 more sources