Results 21 to 30 of about 8,062 (139)

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission. [PDF]

Sci Rep, 2016
AbstractSynaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. SV2A also serves as a specific binding site for certain antiepileptics and is implicated in the treatment of epilepsy.
Tokudome K, Okumura T, Shimizu S, Mashimo T, Takizawa A, Serikawa T, Terada R, Ishihara S, Kunisawa N, Sasa M, Ohno Y.   +10 more
europepmc   +4 more sources

Synaptic Vesicle Glycoprotein 2A Knockout in Parvalbumin and Somatostatin Interneurons Drives Seizures in the Postnatal Mouse Brain. [PDF]

J Neurosci
Synaptic vesicle glycoprotein 2A (SV2A) is a presynaptic protein targeted by the antiseizure drug levetiracetam. One or more of the three SV2 genes is expressed in all neurons and is essential to normal neurotransmission. Loss of SV2A results in a seizure phenotype in mice and mutations in humans are also linked to congenital seizures.
Bartholome O, Neirinckx V, De La Brassinne O, Desloovere J, Van Den Ackerveken P, Raedt R, Rogister B.   +6 more
europepmc   +5 more sources

[¹⁸F]BIBD-181: A Novel Positron Emission Tomography Tracer Specific for Synaptic Vesicle Glycoprotein 2A. [PDF]

ACS Med Chem Lett, 2022
Dysfunction or decreased expression of synaptic vesicle glycoprotein 2A (SV2A) is closely related to the progression of neurodegenerative diseases and psychiatric disorders. The development of positron emission tomography (PET) tracers targeting SV2A can provide a strong imaging basis for the diagnosis and treatment of these diseases.
Jiang Z, Cheng X, Chen H, Zheng W, Sun Y, Yu Z, Yang T, Zhang L, Fan D, Yang Z, Liu Y, Ai L, Wu Z.   +12 more
europepmc   +3 more sources

A Single-Center, Open-Label Positron Emission Tomography Study to Evaluate Brivaracetam and Levetiracetam Synaptic Vesicle Glycoprotein 2A Binding in Healthy Volunteers [PDF]

Epilepsia, 2019
David Matuskey, Nabeel Nabulsi, Pierandrea Muglia   +2 more
exaly   +2 more sources

Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease. [PDF]

Alzheimers Dement
AbstractINTRODUCTIONPositron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated associations between SV2A concentrations in the brain and cerebrospinal fluid (CSF).METHODSTwenty‐one participants with
Mecca AP, Ashton NJ, Chen MK, O'Dell RS, Toyonaga T, Zhao W, Young JJ, Salardini E, Bates KA, Ra J, Goodcase S, Silva-Rudberg JA, Nabulsi NB, Brinkmalm A, Kvartsberg H, Schöll M, Nilsson J, Arnsten AFT, Huang Y, Hansson O, Zetterberg H, Carson RE, Blennow K, van Dyck CH.   +23 more
europepmc   +3 more sources

Synthesis and in vivo evaluation of [¹⁸F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A). [PDF]

Eur J Nucl Med Mol Imaging, 2019
Synaptic abnormalities have been implicated in a variety of neuropsychiatric disorders, including epilepsy, Alzheimer's disease, and schizophrenia. Hence, PET imaging of the synaptic vesicle glycoprotein 2A (SV2A) may be a valuable in vivo biomarker for neurologic and psychiatric diseases. We previously developed [11C]UCB-J, a PET radiotracer with high
Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y.   +12 more
europepmc   +4 more sources

Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem. [PDF]

J Nucl Med, 2022
Synaptic dysfunction is a primary mechanism underlying Huntington disease (HD) progression. This study investigated changes in synaptic vesicle glycoprotein 2A (SV2A) density by means of 11C-UCB-J small-animal PET imaging in the central nervous system of mice with HD.
Bertoglio D, Verhaeghe J, Wyffels L, Miranda A, Stroobants S, Mrzljak L, Dominguez C, Skinbjerg M, Bard J, Liu L, Munoz-Sanjuan I, Staelens S.   +11 more
europepmc   +4 more sources

Validation, kinetic modeling, and test-retest reproducibility of [¹⁸F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice. [PDF]

J Cereb Blood Flow Metab, 2022
Alterations in synaptic vesicle glycoprotein 2 A (SV2A) have been associated with several neuropsychiatric and neurodegenerative disorders. Therefore, SV2A positron emission tomography (PET) imaging may provide a unique tool to investigate synaptic density dynamics during disease progression and after therapeutic intervention. This
Bertoglio D, Zajicek F, Lombaerde S, Miranda A, Stroobants S, Wang Y, Dominguez C, Munoz-Sanjuan I, Bard J, Liu L, Verhaeghe J, Staelens S.   +11 more
europepmc   +3 more sources

Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density

The Cerebellum, 2023
AbstractObjectiveDespite being one of the most prevalent neurological diseases, the pathophysiology of essential tremor (ET) is not fully understood. Neuropathological studies have identified numerous degenerative changes in the cerebellum of ET patients, however. These data align with considerable clinical and neurophysiological data linking ET to the
Yang, Yanghong, Zheng, Chao, Chen, Baosheng, Hernandez, Nora C., Faust, Phyllis L., Cai, Zhengxin, Louis, Elan D., Matuskey, David   +7 more
openaire   +3 more sources

Identification of pre-synaptic density networks using [11C]UCB-J PET imaging and ICA in mice

NeuroImage, 2022
Background: Synaptic vesicle glycoprotein 2A (SV2A) is a vesicle glycoprotein involved in neurotransmitter release. SV2A is located on the pre-synaptic terminals of neurons and visualized using the radioligand [11C]UCB-J and positron emission tomography (
Jordy Akkermans, Franziska Zajicek, Alan Miranda, Mohit H. Adhikari, Daniele Bertoglio   +4 more
doaj   +1 more source