Results 31 to 40 of about 8,062 (139)

Temporal and spatial changes in synaptic vesicle glycoprotein 2A (SV2A) under kainic acid induced epileptogenesis: An autoradiographic study [PDF]

Epilepsy Research, 2022
Synaptic Vesicle Glycoprotein 2A (SV2A) has been proposed as a presynaptic marker in several neurological disorders. Not only is SV2A the target for the antiepileptic drug levetiracetam, but also considered a marker of mature pre-synapses. In this study, we aimed to assess the binding of [3H]UCB-J as a selective radioligand for SV2A to visualize and ...
Pazarlar, Burcu Azak, Madsen, Clara A., Oyar, Eser Öz, Eğilmez, Cansu B., Mikkelsen, Jens D.   +4 more
openaire   +4 more sources

α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease

Biomedicines, 2021
Progressive degeneration of dopaminergic neurons, immune activation, and α-synuclein pathology characterize Parkinson’s disease (PD). We previously reported that unilateral intranigral injection of recombinant adeno-associated viral (rAAV) vectors ...
Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K. Møller, Cecilie Bay-Richter, Søren H. Christiansen, David P. D. Woldbye, Marina Romero-Ramos, Anne M. Landau   +8 more
doaj   +1 more source

Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and 11C-UCB-J PET study

Frontiers in Human Neuroscience, 2023
Introduction: Resting-state network (RSN) connectivity is a widely used measure of the brain’s functional organization in health and disease; however, little is known regarding the underlying neurophysiology of RSNs.
Xiaotian T. Fang, Tommaso Volpi, Sophie E. Holmes, Irina Esterlis, Irina Esterlis, Richard E. Carson, Patrick D. Worhunsky   +6 more
doaj   +1 more source

Synaptic density in aging mice measured by [18F]SynVesT-1 PET

NeuroImage, 2023
Synaptic alterations in certain brain structures are related to cognitive decline in neurodegeneration and in aging. Synaptic loss in many neurodegenerative diseases can be visualized by positron emission tomography (PET) imaging of synaptic vesicle ...
Mengfei Xiong, Sahar Roshanbin, Dag Sehlin, Hanne D. Hansen, Gitte M. Knudsen, Johanna Rokka, Jonas Eriksson, Stina Syvänen   +7 more
doaj   +1 more source

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Nature Communications, 2023
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (HCE) in complex with its neuronal ...
Zheng Liu, Pyung-Gang Lee, Nadja Krez, Kwok-ho Lam, Hao Liu, Adina Przykopanski, Peng Chen, Guorui Yao, Sicai Zhang, Jacqueline M. Tremblay, Kay Perry, Charles B. Shoemaker, Andreas Rummel, Min Dong, Rongsheng Jin   +14 more
doaj   +1 more source

Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain

Molecular Pain, 2019
Background The antiseizure racetams may provide novel molecular insights into neuropathic pain due to their unique mechanism involving synaptic vesicle glycoprotein 2A.
Solomiya Tsymbalyuk, Madeleine Smith, Charles Gore, Orest Tsymbalyuk, Svetlana Ivanova, Charles Sansur, Volodymyr Gerzanich, J Marc Simard   +7 more
doaj   +1 more source

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. [PDF]

ACS Chem Neurosci, 2019
Structural disruption and alterations of synapses are associated with many brain disorders including Alzheimer's disease, epilepsy, depression, and schizophrenia. We have previously developed the PET radiotracer 11C-UCB-J for imaging and quantification of synaptic vesicle glycoprotein 2A (SV2A) and synaptic density in nonhuman primates and humans. Here
Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y.   +10 more
europepmc   +4 more sources

Assessing non-invasive quantitative methods for [¹⁸F]SynVesT-1 PET imaging of synaptic vesicle glycoprotein 2A in the rat brain. [PDF]

Eur J Nucl Med Mol Imaging
Synaptic vesicle glycoprotein 2A (SV2A) is a critical biomarker for evaluating synaptic density in neurological research. Among available radioligands, [18F]SynVesT-1 is increasingly used in PET research because of its extended half-life, while having comparable pharmacokinetic properties to the widely used [11C]UCB-J. However, quantitative application
Berckmans L, Schrauwen C, Miranda A, Staelens S, Bertoglio D.   +4 more
europepmc   +3 more sources

Fluid Biomarkers for Synaptic Dysfunction and Loss

Biomarker Insights, 2020
Synapses are the site for brain communication where information is transmitted between neurons and stored for memory formation. Synaptic degeneration is a global and early pathogenic event in neurodegenerative disorders with reduced levels of pre- and ...
Elena Camporesi, Johanna Nilsson, Ann Brinkmalm, Bruno Becker, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg   +6 more
doaj   +1 more source

Lower synaptic density associated with gaming disorder: an 18F-SynVesT-1 PET imaging study

General Psychiatry, 2023
Background Internet gaming disorder (IGD) is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.
Jiang Long, Ming Zhou, Na Zhong, Qian Xiao, Ling Xiao, Ming Yuan, Tao Luo, Jiale Hou, Shuo Hu, Huixi Dong   +9 more
doaj   +1 more source