Results 1 to 10 of about 539,046 (150)

A missense mutation of the gene encoding synaptic vesicle glycoprotein 2A (SV2A) confers seizure susceptibility by disrupting amygdalar synaptic GABA release [PDF]

Frontiers in Pharmacology, 2016
Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently
Kentaro Tokudome, Takahiro Okumura, Ryo Terada, Saki Shimizu, Naofumi Kunisawa, Tomoji Mashimo, Tomoji Mashimo, Tadao Serikawa, Tadao Serikawa, Masashi Sasa, Yukihiro Ohno   +10 more
doaj   +9 more sources

Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer’s Disease Patients [PDF]

Frontiers in Cellular Neuroscience, 2019
Sections from the middle frontal gyrus (Brodmann area 46) of autopsy-confirmed Alzheimer’s disease (AD) patients and non-demented subjects were examined for the prevalence of hallmark AD pathology, including amyloid-β (Aβ) plaques, phosphorylated tau ...
Athanasios Metaxas, Camilla Thygesen, Sanne R. R. Briting, Anne M. Landau, Anne M. Landau, Sultan Darvesh, Sultan Darvesh, Bente Finsen   +7 more
doaj   +12 more sources

Synaptic Vesicle Glycoprotein 2A: Features and Functions

Frontiers in Neuroscience, 2022
In recent years, the field of neuroimaging dramatically moved forward by means of the expeditious development of specific radioligands of novel targets.
Rachele Rossi, Rachele Rossi, Shokouh Arjmand, Simone Larsen Bærentzen, Simone Larsen Bærentzen, Albert Gjedde, Albert Gjedde, Albert Gjedde, Anne M. Landau, Anne M. Landau   +9 more
doaj   +4 more sources

SV2A PET imaging in human neurodegenerative diseases [PDF]

Frontiers in Aging Neuroscience
This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrity using Positron Emission Tomography (PET) in neurodegenerative diseases.
Mahsa Shanaki Bavarsad, Lea T. Grinberg
doaj   +4 more sources

Sleep deprivation increases levels of the synaptic density marker SV2A in the human brain. [PDF]

PLoS Biology
Sleep is essential for synaptic homeostasis, a proposed mechanism whereby wakefulness leads to synaptic potentiation and sleep facilitates synaptic down-selection.
David Elmenhorst, Anna L Foerges, Ali Gordji-Nejad, Eva-Maria Elmenhorst, Tina Kroll, Andreas Matusch, Simone Beer, Bernd Neumaier, Philipp Krapf, Christoph Lerche, Alexander Drzezga, Andreas Bauer   +11 more
doaj   +2 more sources

Fully Automated Azeotropic Drying-Free Synthesis of [¹⁸F]SynVesT-1 via Copper-Mediated Fluorination Using the Trasis All-in-One Module [PDF]

Molecules
Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane protein expressed in presynaptic vesicles. Positron emission tomography (PET) imaging of SV2A provides an in vivo measure of synaptic density and has broad applications in the study of ...
Falguni Basuli, Jianfeng Shi, Xiang Zhang, Rolf E. Swenson   +3 more
doaj   +2 more sources

Psilocybin’s effect on human brain synaptic plasticity [PDF]

Translational Psychiatry
Psychedelics such as psilocybin have been linked to enhanced neuroplasticity and symptom relief in affective disorders, but the neurobiological mechanisms and impact of environmental context remain unclear.
Annette Johansen, Pontus Plavén-Sigray, Martin K. Madsen, Anna Søndergaard, Catharina Messel, Maria Geisler, Arafat Nasser, Drummond E-W. McCulloch, Vincent Beliveau, Alexandra Vassilieva, Anton Lund, Szabolcs Lehel, Brice Ozenne, Dea S. Stenbæk, Patrick M. Fisher, Claus Svarer, Gitte M. Knudsen   +16 more
doaj   +2 more sources

Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study [PDF]

The Journal of Clinical Investigation
Alcohol use disorder (AUD) is linked with changes in brain structure and function, with robust evidence for neurodegenerative changes, including synaptic loss in preclinical models.
Sarah K. Royse, Rajesh Narendran
doaj   +2 more sources

Detection of Synaptic Vesicle Glycoprotein 2A in Serum Using a Polypyrrole-Functionalized Graphene Oxide Electrochemical Immunosensor [PDF]

Nanomaterials
Early intervention is pivotal for mitigating the progression of Alzheimer’s disease (AD). This study presents an electrochemical immunosensor targeting synaptic vesicle glycoprotein 2A (SV2A) to facilitate early AD diagnosis.
Yonghong Zhao, Le Li, Jiale Tao, Manying Yang, Chen Li, Xiaoqian Zhang, Yang Zhang, Shiguo Sun, Na Zhao   +8 more
doaj   +2 more sources

Automated GMP production and long-term experience in radiosynthesis of the SV2A tracer [11C]UCB-J [PDF]

EJNMMI Radiopharmacy and Chemistry
Background Positron emission tomography (PET) is a non-invasive imaging technique that enables the quantification of specific biological and pharmacological processes in vivo.
Saara Wahlroos, Anna Krzyczmonik, Semi Helin, Johan Rajander, Olof Solin, Anna K. Kirjavainen   +5 more
doaj   +2 more sources