Results 41 to 50 of about 539,046 (150)

SDI-118, a novel procognitive SV2A modulator: First-in-human randomized controlled trial including PET/fMRI assessment of target engagement

Frontiers in Pharmacology, 2023
Background: Current treatments for progressive neurodegenerative disorders characterized by cognitive impairment either have limited efficacy or are lacking altogether.
Wouter Botermans, Michel Koole, Koen Van Laere, Jonathan R. Savidge, John A. Kemp, Stefan Sunaert, Maeve M. Duffy, Steven Ramael, Andrea M. Cesura, Kevin D’Ostilio, Denis Gossen, Torsten M. Madsen, Thomas Lodeweyckx, Jan de Hoon   +13 more
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[¹⁸F]BIBD-181: A Novel Positron Emission Tomography Tracer Specific for Synaptic Vesicle Glycoprotein 2A

, 2022
Dysfunction or decreased expression of synaptic vesicle glycoprotein 2A (SV2A) is closely related to the progression of neurodegenerative diseases and psychiatric disorders. The development of positron emission tomography (PET) tracers targeting SV2A can
Yuli Sun (554700), Zehui Wu (2082394), Ziyue Yu (12321839), Xuebo Cheng (379757), Yajing Liu (728964), Zeng Jiang (11303676), Wei Zheng (25452), Lin Ai (107138), Tingyu Yang (10686507), Di Fan (170169), Hualong Chen (8682036), Lu Zhang (50563), Zhihao Yang (125036)   +12 more
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Lower synaptic density associated with gaming disorder: an 18F-SynVesT-1 PET imaging study

General Psychiatry, 2023
Background Internet gaming disorder (IGD) is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.
Jiang Long, Ming Zhou, Na Zhong, Qian Xiao, Ling Xiao, Ming Yuan, Tao Luo, Jiale Hou, Shuo Hu, Huixi Dong   +9 more
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Synthesis and Preclinical Evaluation of an ¹⁸F‑Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [¹⁸F]SynVesT‑2

, 2020
Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane glycoprotein ubiquitously expressed in presynaptic vesicles. In vivo imaging of SV2A using PET has potential applications in the diagnosis and prognosis of a variety of neuropsychiatric ...
Marcel Lindemann, Zhengxin Cai (1328304), Nabeel Nabulsi, Sjoerd J. Finnema, Songye Li, David C. Labaree, Takuya Toyonaga, Sjoerd J. Finnema (1408846), Evan Baum, Richard E. Carson, Richard E. Carson (2563657), Yiyun Huang (2563660), Zhengxin Cai, Jim Ropchan, Yiyun Huang, Anupama Shirali (2384131), Xiaoai Wu, Marcel Lindemann (8399940), Nabeel Nabulsi (2856149), Anupama Shirali, Wenjie Zhang (179664), Wenjie Zhang, Daniel Holden (1396597), Xiaoai Wu (6598460), Songye Li (3227994), Shu-fei Lin, David C. Labaree (2641411), Evan Baum (6377699), Jim Ropchan (3227997), Richard Pracitto, Daniel Holden, Shu-fei Lin (6410144), Takuya Toyonaga (3391694), Richard Pracitto (3228000)   +33 more
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The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer’s Disease: Implications for Treatment [PDF]

, 2021
Alzheimer’s disease (AD), a serious neurodegenerative disease, is pathologically characterized by synaptic loss and dysfunction. Synaptic vesicle protein 2A (SV2A) is an indispensable vesicular protein specifically expressed in synapses and can be used ...
Zhang, Shibo, Liu, Xuanting, Bomin Sun, Xie, Fang, Guan, Yihui, Zhou, Yinping, Yihui Guan, Ruiqing Ni, Fang Xie, Zhengwei Zhang, Shibo Zhang, Li, Weihao, Zhou, Weiyan, Chencheng Zhang, Kong, Yanyan, Zhang, Chencheng, Jiao Wang, Ni, Ruiqing; id_orcid, Wang, Jiao, Jiang, Donglang, Xuanting Liu, Weihao Li, Yinping Zhou, Donglang Jiang, Liu, Cuiping, Weiyan Zhou, Zhang, Zhengwei, Yanyan Kong, Lin Huang, Huang, Lin, Cuiping Liu, Sun, Bomin   +31 more
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Synaptic vesicle glycoprotein 2A is affected in the CNS of Huntington\u2019s Disease mice and post-mortem human HD brain

, 2021
: Synaptic dysfunction is a primary mechanism underlying Huntington\u2019s Disease (HD) progression. This study investigated changes in synaptic vesicle glycoprotein 2A (SV2A) density by means of 11C-UCB-J microPET imaging in the central nervous system ...
Dominguez, Celia, Bard, Jonathan, Stroobants, Sigrid, Mrzljak, Ladislav, Wyffels, Leonie, Munoz-Sanjuan, Ignacio, Verhaeghe, Jeroen, Staelens, Steven, Skinbjerg, Mette, Liu, Longbin, Bertoglio, Daniele, Miranda, Alan, Alan Miranda, Leonie Wyffels, Steven Staelens, Celia Dominguez, Longbin Liu, Jeroen Verhaeghe, Mette Skinbjerg, Sigrid Stroobants, Daniele Bertoglio, Ladislav Mrzljak, Jonathan Bard, Ignacio Munoz-Sanjuan   +23 more
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Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging

NeuroImage: Clinical, 2023
Objective: In preclinical research, the use of [18F]Fluorodesoxyglucose (FDG) as a biomarker for neurodegeneration may induce bias due to enhanced glucose uptake by immune cells.
Letizia Vogler, Anna Ballweg, Bernd Bohr, Nils Briel, Karin Wind, Melissa Antons, Lea H. Kunze, Johannes Gnörich, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Guido Boening, Sibylle I. Ziegler, Johannes Levin, Andreas Zwergal, Günter U. Höglinger, Jochen Herms, Matthias Brendel   +18 more
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Generation of a SV2A knockout human embryonic stem cell line by CRISPR/Cas9 system

Stem Cell Research
Synaptic Vesicle Glycoprotein 2A (SV2A) is a ubiquitously expressed brain glycoprotein, localized to synaptic terminals. It regulates vesicle exocytosis, maintains neurotransmitter release, and serves as a receptor for both botulinum neurotoxins (e.g ...
Feng Yao, Xing Qi, Shan Yongli, Zhong Xiaofen   +3 more
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Synaptic density in healthy human aging is not influenced by age or sex: a 11C-UCB-J PET study

NeuroImage, 2021
Rationale: 11C-UCB-J binds to synaptic vesicle glycoprotein 2A, a protein ubiquitously expressed in presynaptic nerve terminals, and can therefore serve as in vivo proxy of synaptic density.
Laura Michiels, Aline Delva, June van Aalst, Jenny Ceccarini, Wim Vandenberghe, Mathieu Vandenbulcke, Michel Koole, Robin Lemmens, Koen Van Laere   +8 more
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Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET) [PDF]

, 2022
PURPOSE: Exploring synaptic density changes during brain growth is crucial to understanding brain development. Previous studies in nonhuman primates report a rapid increase in synapse number between the late gestational period and the early neonatal ...
Kukis, David, Berg, Eric, Ropchan, Jim, Toyonaga, Takuya, Felchner, Zachary, Benveniste, Helene, Tarantal, Alice F, Nabulsi, Nabeel, Carson, Richard E, Rossano, Samantha, Carson, Richard E., Lorence, Isabella, Fowles, Krista, Huang, Yiyun, Groman, Stephanie, Ye, Yunpeng, Tarantal, Alice F., Li, Songye, Zachary Felchner, Krista Fowles, Nabeel Nabulsi, Songye Li, Takuya Toyonaga, Eric Berg, Richard E. Carson, Yunpeng Ye, Isabella Lorence, Jim Ropchan, Yiyun Huang, David Kukis, Helene Benveniste, Stephanie Groman, Samantha Rossano, Alice F. Tarantal   +33 more
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