Results 31 to 40 of about 539,046 (150)

Synaptic density in aging mice measured by [18F]SynVesT-1 PET

NeuroImage, 2023
Synaptic alterations in certain brain structures are related to cognitive decline in neurodegeneration and in aging. Synaptic loss in many neurodegenerative diseases can be visualized by positron emission tomography (PET) imaging of synaptic vesicle ...
Mengfei Xiong, Sahar Roshanbin, Dag Sehlin, Hanne D. Hansen, Gitte M. Knudsen, Johanna Rokka, Jonas Eriksson, Stina Syvänen   +7 more
doaj   +1 more source

Comparison of ABBV-552 Safety and Pharmacokinetics in Healthy Asian and Western Adults. [PDF]

Clin Pharmacol Drug Dev
Abstract ABBV‐552, a positive modulator of synaptic vesicle glycoprotein 2A (SV2A), was under investigation as a treatment for cognitive impairment related to Alzheimer's disease. This Phase 1, multicenter, open‐label, parallel cohort study (NCT05686980) was conducted to examine the pharmacokinetics (PK), safety, and tolerability of ABBV‐552 in healthy
Miles N, McNamee B, Zadikoff C, Boiser J, Shebley M, Boinpally R.   +5 more
europepmc   +2 more sources

Synaptic vesicle protein 2A as a potential biomarker in synaptopathies [PDF]

, 2019
Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in ...
Blennow, Kaj,, Zimmer, ER, Heurling, K, Leuzy, Antoine,, Blennow, K, Zimmer, Eduardo R.,, Eriksson, Jonas,, Ashton, NJ, Lubberink, M, Lubberink, Mark, Lubberink, Mark,, Ashton, Nicholas J.,, Schöll, Michael, Leuzy, Antoine, Heurling, Kerstin, Ashton, Nicholas J, Zetterberg, H, Schöll, M, Zimmer, Eduardo R., Zetterberg, Henrik,, Zetterberg, Henrik, Eriksson, J, Heurling, Kerstin,, Leuzy, A, Schöll, Michael,, Blennow, Kaj, Eriksson, Jonas, Zimmer, Eduardo R, Lund University., Ashton, Nicholas J.   +29 more
core   +2 more sources

Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease

NeuroImage, 2021
Purpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD).
Yihuan Lu, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Ming-Kai Chen, Adam P. Mecca, Christopher H. van Dyck, Richard E. Carson   +7 more
doaj   +1 more source

Left Cerebellar-Right Frontal Uncoupling in Female First-Episode Major Depressive Disorder: Synaptic Evidence From [¹⁸F]UCB-H PET. [PDF]

CNS Neurosci Ther
This study investigates cerebello‐cerebral synaptic function in female first‐episode major depressive disorder (FMD) using [18F]UCB‐H PET imaging. Compared to healthy controls (HCs), FMD patients show reduced SUVR in the left cerebellar lobule VII and synaptic tracer uptake in the left cerebellar lobule VIII, which correlates negatively with depression
Wang J, Lin Y, Zhang T, Xu P, Lei S, Yang H, Chen Z.   +6 more
europepmc   +2 more sources

Persistent Post-Traumatic Brain Injury Hiccups Unresponsive to Standard Agents: Resolution Associated With Levetiracetam Therapy. [PDF]

Clin Case Rep
ABSTRACT Post‐traumatic hiccups are an uncommon but distressing complication of traumatic brain injury (TBI), often resistant to conventional pharmacological agents, and the underlying mechanism may involve central neurological disruption of inhibitory pathways rather than gastrointestinal or metabolic aetiologies. We report a male patient in his early
Karajeh R, Khalaf RA, Alrob MIA, Azzam SKA, Alsaeed YA.   +4 more
europepmc   +2 more sources

[18F]BIBD-181: A Novel Positron Emission Tomography Tracer Specific for Synaptic Vesicle Glycoprotein 2A

, 2022
Dysfunction or decreased expression of synaptic vesicle glycoprotein 2A (SV2A) is closely related to the progression of neurodegenerative diseases and psychiatric disorders. The development of positron emission tomography (PET) tracers targeting SV2A can
Tingyu Yang, Lu Zhang, Zehui Wu (2082394), Xuebo Cheng (379757), Zeng Jiang (11303676), Tingyu Yang (10686507), Di Fan, Hualong Chen, Zhihao Yang, Yuli Sun, Yuli Sun (554700), Yajing Liu, Ziyue Yu (12321839), Zeng Jiang, Wei Zheng, Yajing Liu (728964), Wei Zheng (25452), Lin Ai (107138), Di Fan (170169), Ziyue Yu, Zehui Wu, Hualong Chen (8682036), Lu Zhang (50563), Zhihao Yang (125036), Lin Ai, Xuebo Cheng   +25 more
core   +1 more source

The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain

EJNMMI Research, 2021
Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent and human ...
Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret, Nadja Van Camp   +11 more
doaj   +1 more source

α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease

Biomedicines, 2021
Progressive degeneration of dopaminergic neurons, immune activation, and α-synuclein pathology characterize Parkinson’s disease (PD). We previously reported that unilateral intranigral injection of recombinant adeno-associated viral (rAAV) vectors ...
Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K. Møller, Cecilie Bay-Richter, Søren H. Christiansen, David P. D. Woldbye, Marina Romero-Ramos, Anne M. Landau   +8 more
doaj   +1 more source

Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia

, 2012
Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility.
Meier, Sandra, Sauer, Heinrich, Herms, Stefan, Strohmaier, Jana, Alblas, Margrieta, Cichon, Sven, Mattheisen, Manuel, Witt, Stephanie H., Giegling, Ina, Muehleisen, Thomas W., Hoffmann, Per, Rietschel, Marcella, Noethen, Markus M., Nenadic, Igor, Treutlein, Jens, Degenhardt, Franziska A., Rujescu, Dan, Schulze, Thomas G.   +17 more
core   +2 more sources