Results 11 to 20 of about 539,046 (150)

Synaptic Vesicle Glycoprotein 2A (SV2A) Regulates Kindling Epileptogenesis via GABAergic Neurotransmission [PDF]

Scientific Reports, 2016
AbstractSynaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. SV2A also serves as a specific binding site for certain antiepileptics and is implicated in the treatment of epilepsy.
Yukihiro Ohno, Tomoji Mashimo, Naofumi Kunisawa   +2 more
exaly   +7 more sources

Increased Expression of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Brain of Chronic Diabetic Rats [PDF]

Synapse
ABSTRACTAim/hypothesisDiabetes mellitus has been reported to be a risk factor for cognitive dysfunction, depression, stroke, and seizures. Diabetic pathology is believed to interfere with synaptic plasticity. Synaptic vesicle glycoprotein 2A (SV2A) is a presynaptic vesicular protein and a popular synaptic density imaging marker.
Jens Damsgaard Mikkelsen, Burcu A Pazarlar   +1 more
exaly   +6 more sources

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates [PDF]

ACS Chemical Neuroscience, 2019
Structural disruption and alterations of synapses are associated with many brain disorders including Alzheimer's disease, epilepsy, depression, and schizophrenia. We have previously developed the PET radiotracer 11C-UCB-J for imaging and quantification of synaptic vesicle glycoprotein 2A (SV2A) and synaptic density in nonhuman primates and humans. Here
Nabeel Nabulsi, Zhengxin Cai, Xiaoai Wu
exaly   +5 more sources

Cerebrospinal Fluid and Brain Positron Emission Tomography Measures of Synaptic Vesicle Glycoprotein 2A: Biomarkers of Synaptic Density in Alzheimer's Disease [PDF]

Alzheimer's and Dementia
INTRODUCTION: Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated associations between SV2A
Ryan S O'Dell, Juan Young, Ming-Kai Chen
exaly   +3 more sources

Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent ¹⁸F-Labeled Ligand ([¹⁸F]UCB-H)

Journal of Medicinal Chemistry, 2016
We herein describe the straightforward synthesis of a stable pyridyl(4-methoxyphenyl)iodonium salt and its [18F] radiolabeling within a one-step, fully automated and cGMP compliant radiosynthesis of [18F]UCB-H ([18F]7), a PET tracer for the imaging of synaptic vesicle glycoprotein 2A (SV2A).
Corentin, Warnier, Christian, Lemaire, Guillaume, Becker, Guillermo, Zaragoza, Fabrice, Giacomelli, Joël, Aerts, Muhammad, Otabashi, Mohamed Ali, Bahri, Joël, Mercier, Alain, Plenevaux, André, Luxen   +10 more
core   +4 more sources

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2 [PDF]

Nature Communications, 2023
Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (HCE) in complex with its neuronal ...
Zheng Liu, Pyung-Gang Lee, Nadja Krez, Kwok-ho Lam, Hao Liu, Adina Przykopanski, Peng Chen, Guorui Yao, Sicai Zhang, Jacqueline M. Tremblay, Kay Perry, Charles B. Shoemaker, Andreas Rummel, Min Dong, Rongsheng Jin   +14 more
doaj   +2 more sources

Synaptic Vesicle Glycoprotein 2A (SV2A) Levels in the Cerebral Cortex in Patients with Alzheimer Disease: A Radioligand Binding Study in Post-Mortem Brains

SSRN Electronic Journal, 2022
Histological and biochemical analyses in postmortem tissues have demonstrated neurodegenerative changes in the cerebral cortex in patients with Alzheimer's disease (AD), and it has been suggested that this represents a loss of synapses. PET imaging of the (pre)synaptic vesicular glycoprotein 2A (SV2A) has demonstrated a reduction in synapse density in ...
Mikkelsen, Jens D., Kaad, Sif, Aripaka, Sanjay S., Finsen, Bente   +3 more
openaire   +5 more sources

SV2A is expressed in synapse subpopulations in mouse and human brain: implications for PET radiotracer studies [version 1; peer review: 2 approved]

Wellcome Open Research
Synapse pathology is a feature of most brain diseases and there is a pressing need to monitor the onset and progression of this pathology using brain imaging in living patients.
Adriana Tavares, Zhen Qiu, Beverley Notman, Colin Smith, Theresa Wong, Seth G. N. Grant   +5 more
doaj   +2 more sources

Altered lipid peroxidation, perineuronal net and oligodendrocyte markers in the frontal cortex of a dual-hit neurodevelopmental model support its relevance to schizophrenia [PDF]

Frontiers in Cellular Neuroscience
IntroductionThe pathogenesis of schizophrenia begins in early neurodevelopment and leads to an array of frontal cortical deficits. They include redox dysregulation, white matter perturbation, loss of perineuronal nets (PNNs) and reduced synaptic density.
Victoria Esuaikoh, Sarah Ibegbulam, Alistair Cook, Bianca McFarland, Nora Nunnington, Ambalangoda Perera, Jingjing Feng, Jennifer A. Cale, Madeleine V. King   +8 more
doaj   +2 more sources

Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery [PDF]

Biomedicines
Major depressive disorder remains a leading cause of disability, and decades of monoamine-centered pharmacology have yielded delayed and often incomplete relief.
Masaru Tanaka
doaj   +2 more sources