Results 61 to 70 of about 8,062 (139)

The pharmacokinetics of [18F]UCB-H revisited in the healthy non-human primate brain

EJNMMI Research, 2021
Background Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [18F]UCB-H was one of the first promising SV2A-ligands to be labelled and used in vivo in rodent and human ...
Sébastien Goutal, Martine Guillermier, Guillaume Becker, Mylène Gaudin, Yann Bramoullé, André Luxen, Christian Lemaire, Alain Plenevaux, Eric Salmon, Philippe Hantraye, Olivier Barret, Nadja Van Camp   +11 more
doaj   +1 more source

SDI-118, a novel procognitive SV2A modulator: First-in-human randomized controlled trial including PET/fMRI assessment of target engagement

Frontiers in Pharmacology, 2023
Background: Current treatments for progressive neurodegenerative disorders characterized by cognitive impairment either have limited efficacy or are lacking altogether.
Wouter Botermans, Michel Koole, Koen Van Laere, Jonathan R. Savidge, John A. Kemp, Stefan Sunaert, Maeve M. Duffy, Steven Ramael, Andrea M. Cesura, Kevin D’Ostilio, Denis Gossen, Torsten M. Madsen, Thomas Lodeweyckx, Jan de Hoon   +13 more
doaj   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Synthesis and Preclinical Evaluation of¹¹C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain [PDF]

Journal of Nuclear Medicine, 2016
The synaptic vesicle glycoprotein 2A (SV2A) is found in secretory vesicles in neurons and endocrine cells. PET with a selective SV2A radiotracer will allow characterization of drugs that modulate SV2A (e.g., antiepileptic drugs) and potentially could be a biomarker of synaptic density (e.g., in neurodegenerative disorders).
Nabeel B, Nabulsi, Joël, Mercier, Daniel, Holden, Stephane, Carré, Soheila, Najafzadeh, Marie-Christine, Vandergeten, Shu-Fei, Lin, Anand, Deo, Nathalie, Price, Martyn, Wood, Teresa, Lara-Jaime, Florian, Montel, Marc, Laruelle, Richard E, Carson, Jonas, Hannestad, Yiyun, Huang   +15 more
openaire   +2 more sources

Trigeminal and facial branchiomotor neurons have shared muscle targets in zebrafish larvae

Journal of Anatomy, EarlyView.
Cranial nerve innervation map, based on previous studies, shows the trigeminal and facial motor nerves confined to the mandibular and hyoid arch muscles, respectively, except for the trigeminal nerve in the interhyoideus muscle (M.IH). The revised cranial nerve innervation map, based on this study, shows the facial nerve in the intermandibularis ...
Ritika Ghosal, Kimberly L. McArthur, Johann K. Eberhart   +2 more
wiley   +1 more source

Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams

Nature Communications
The synaptic vesicle glycoprotein 2A (SV2A) is a synaptic vesicle (SV) resident with homology to the major facilitator superfamily (MFS) and essential in vertebrate neurotransmission.
Stephan Schenck, Toon Laeremans, Jan Steyaert, Janine D. Brunner   +3 more
doaj   +1 more source

SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses

Molecular Brain, 2019
Proper sorting of exocytosed synaptic vesicle (SV) proteins into individual SVs during endocytosis is of the utmost importance for the fidelity of subsequent neurotransmission.
Sang-Eun Lee, Soomin Jeong, Unghwi Lee, Sunghoe Chang   +3 more
doaj   +1 more source

A Müller Glia‐Retinal Pigment Epithelium Apical Network Surrounding Cone Outer Segments in Fish and Mouse

Glia, Volume 74, Issue 12, December 2026.
Müller glia and the retinal pigment epithelium interact around cone outer segment in the subretinal space of both zebrafish and mouse. The contacts are established early during development but subsequent to outer segment emergence. ABSTRACT Homeostasis of the vertebrate retina critically depends on two non‐neuronal cell populations, Müller glia and the
Maria Sharkova, Michael Housset, Samantha Boudreau, Chavy Dworkind, Sara Amidian, Michel Cayouette, Jennifer C. Hocking   +6 more
wiley   +1 more source

Presence of Cleaved Synaptosomal-Associated Protein-25 and Decrease of Purinergic Receptors P2X3 in the Bladder Urothelium Influence Efficacy of Botulinum Toxin Treatment for Overactive Bladder Syndrome. [PDF]

PLoS ONE, 2015
To evaluate whether botulinum toxin A (BoNT-A) injection and Lipotoxin (liposomes with 200 U of BoNT-A) instillation target different proteins, including P2X3, synaptic vesicle glycoprotein 2A, and SNAP-25, in the bladder mucosa, leading to different ...
Hsin-Tzu Liu, Sung-Ho Chen, Michael B Chancellor, Hann-Chorng Kuo   +3 more
doaj   +1 more source