Results 81 to 90 of about 8,062 (139)

Synaptic loss and its association with symptom severity in Parkinson’s disease

npj Parkinson's Disease
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD and other ...
Sophie E. Holmes, Praveen Honhar, Sule Tinaz, Mika Naganawa, Ansel T. Hilmer, Jean-Dominique Gallezot, Mark Dias, Yanghong Yang, Takuya Toyonaga, Irina Esterlis, Adam Mecca, Christopher Van Dyck, Shannan Henry, Jim Ropchan, Nabeel Nabulsi, Elan D. Louis, Robert Comley, Sjoerd J. Finnema, Richard E. Carson, David Matuskey   +19 more
doaj   +1 more source

SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55γ

Journal of Lipid Research, 2007
Sterol-regulatory element binding proteins (SREBPs) control the expression of genes involved in fatty acid and cholesterol biosynthesis. Using microarrays, we observed that mature SREBP-1 also induced the expression of genes unrelated to lipid metabolism,
Anders Kallin, Lene E. Johannessen, Patrice D. Cani, Catherine Y. Marbehant, Ahmed Essaghir, Fabienne Foufelle, Pascal Ferré, Carl-Henrik Heldin, Nathalie M. Delzenne, Jean-Baptiste Demoulin   +9 more
doaj   +1 more source

Levetiracetam Effect on Hematological Indices in children with Idiopathic Epilepsy [PDF]

Zagazig University Medical Journal
Background: Levetiracetam (LEV) is a well-known broad-spectrum antiepileptic drug, approved by FDA, for proper and effective control of both focal and generalized epilepsy.
Eman Abdel Hady, Safaa Ahmed, Abdallah Abd el hameed, Ghada Hegazy, Seham Ibrahim   +4 more
doaj   +1 more source

Automated GMP production and long-term experience in radiosynthesis of the SV2A tracer [11C]UCB-J

EJNMMI Radiopharmacy and Chemistry
Background Positron emission tomography (PET) is a non-invasive imaging technique that enables the quantification of specific biological and pharmacological processes in vivo.
Saara Wahlroos, Anna Krzyczmonik, Semi Helin, Johan Rajander, Olof Solin, Anna K. Kirjavainen   +5 more
doaj   +1 more source

Preliminary evidence for preserved synaptic density in late-life depression

Translational Psychiatry
Late-life depression has been consistently associated with lower gray matter volume, the origin of which remains largely unexplained. Recent in-vivo PET findings in early-onset depression and Alzheimer’s Disease suggest that synaptic deficits contribute ...
Thomas Vande Casteele, Maarten Laroy, Margot Van Cauwenberge, Michel Koole, Patrick Dupont, Stefan Sunaert, Jan Van den Stock, Filip Bouckaert, Koen Van Laere, Louise Emsell, Mathieu Vandenbulcke   +10 more
doaj   +1 more source

Dose reduction for synaptic density PET imaging in Parkinson’s disease

NeuroImage
Objective: Dynamic PET imaging with 11C-UCB-J enables in vivo quantification of synaptic vesicle glycoprotein 2A (SV2A), with prior reports of lower synaptic density in areas such as the brainstem nuclei and substantia nigra (SN) in Parkinson’s disease ...
Andi Li, Mika Naganawa, Praveen Honhar, Kathryn Fontaine, Paul Gravel, David Matuskey, Richard E. Carson, Jing Tang   +7 more
doaj   +1 more source

Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A

Nature Communications
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV), shows improved efficacy.
Atsushi Yamagata, Kaori Ito, Takehiro Suzuki, Naoshi Dohmae, Tohru Terada, Mikako Shirouzu   +5 more
doaj   +1 more source

Epilepsy caused by an abnormal alternative splicing with dosage effect of the SV2A gene in a chicken model.

PLoS ONE, 2011
Photosensitive reflex epilepsy is caused by the combination of an individual's enhanced sensitivity with relevant light stimuli, such as stroboscopic lights or video games.
Marine Douaud, Katia Feve, Fabienne Pituello, David Gourichon, Simon Boitard, Eric Leguern, Gérard Coquerelle, Agathe Vieaud, Cesira Batini, Robert Naquet, Alain Vignal, Michèle Tixier-Boichard, Frédérique Pitel   +12 more
doaj   +1 more source

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

Scientific Reports, 2018
This report demonstrates insoluble alpha-synuclein (aSYN)+ aggregates in human sporadic Parkinson’s disease (PD) midbrain that are linearly correlated with loss of glucocerebrosidase (GCase) activity.
Oeystein R. Brekk, Alyssa Moskites, Ole Isacson, Penelope J. Hallett   +3 more
doaj   +1 more source

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

Alzheimer’s Research & Therapy
Background The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer’s disease (AD).
Elaheh Salardini, Ryan S. O’Dell, Em Tchorz, Nabeel B. Nabulsi, Yiyun Huang, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca   +7 more
doaj   +1 more source