Results 101 to 110 of about 8,062 (139)

A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release

A Missense Mutation of the Gene Encoding Synaptic Vesicle Glycoprotein 2A (SV2A) Confers Seizure Susceptibility by Disrupting Amygdalar Synaptic GABA Release
Synaptic vesicle glycoprotein 2A (SV2A) is specifically expressed in the membranes of synaptic vesicles and modulates action potential-dependent neurotransmitter release. To explore the role of SV2A in the pathogenesis of epileptic disorders, we recently generated a novel rat model (Sv2a[L174Q] rat) carrying a missense mutation of the Sv2a gene and ...
openaire   +1 more source

Mapping the Synaptome in Neurodegeneration: Emerging Clinical Applications of SV2A PET Imaging. [PDF]

Mol Diagn Ther
Filippi L, Nuvoli S, Spanu A, Palumbo B.
europepmc   +1 more source

Rabies Virus Glycoprotein G Variation Is Associated with Neurovirulence and Reduced Vamp2 Abundance in a Mouse Model of Direct CNS Infection. [PDF]

Vet Sci
Liu C, Guo H, Yin K, Sun Y, Ma Z, Wang F, Niu Y, Wen Y.   +7 more
europepmc   +1 more source

Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison of ¹ ⁸F-SynVesT-1 and ¹ ⁸F-FDG PET. [PDF]

Alzheimers Dement
Fesharaki-Zadeh A, Cayir S, Ibrahim W, Yang Y, Gallezot JD, Naganawa M, Wu Y, Toyonaga T, Sadabad FE, O'Dell R, Pittman B, Nabulsi N, Strittmatter S, Carson RE, Huang Y, van Dyck CH, Mecca AP, Matuskey D.   +17 more
europepmc   +1 more source

Sleep differentially modulates synaptic vesicle protein 2A and spine density across cortical regions and development. [PDF]

iScience
Ma J, Braun A, Oskamp A, Kricsfalussy-Hrabár L, Hermes N, Djakkani S, Holz U, Jakobs S, Klein S, Stüsgen S, Krapf P, Neumaier B, Drzezga A, Beer S, Bauer A, Rollenhagen A, Kampa B, Elmenhorst D.   +17 more
europepmc   +1 more source

A serotonergic perspective on depression in Parkinson's disease: From synaptic disruption to network failure. [PDF]

Neural Regen Res
Miquel-Rio L, Jericó-Escolar J, Bortolozzi A.   +2 more
europepmc   +1 more source

Parkinson's Disease-Associated Remodeling of Synaptic <i>N</i>-Glycans in the Human Prefrontal Cortex. [PDF]

J Proteome Res
Adeniyi M, Fowowe M, Oluokun O, Sahioun S, Sandilya V, Daramola O, Bennett AI, Mechref Y.   +7 more
europepmc   +1 more source

SV2A PET Imaging Detects Severity-Dependent Synaptic Changes After Experimental Traumatic Spinal Cord Injury. [PDF]

J Nucl Med
Schrauwen C, Halloin N, Van Eetveldt A, Laermans Z, De Vos WH, Jankovski A, Verhoye M, Staelens S, Nicaise C, Bertoglio D.   +9 more
europepmc   +1 more source

Detection of Focal Lesions in Epilepsy with [¹⁸F]UCB-H Synaptic Vesicle Protein 2A PET Imaging. [PDF]

J Nucl Med
Pakula V, Dorneich JS, Frontzkowski L, Bartos LM, Fearns N, Roemer-Cassiano SN, Lindner S, Zwergal A, Kaufmann E, Höglinger G, Franzmeier N, Werner RA, Vollmar C, Rémi J, Brendel M, Gnörich J.   +15 more
europepmc   +1 more source

The central neurometabolic fingerprint of persistent spinal pain syndrome type 2: A prospective [¹⁸F]FDG PET/CT neuroimaging study. [PDF]

Neurobiol Pain
Burmeister LS, van Grinsven M, van Roosendaal BK, Witkam RL, Arnts I, Janssen S, Wegener J, Vissers KCP, Arens AIJ, Gotthardt M, Rullmann M, Henssen D.   +11 more
europepmc   +1 more source