Results 91 to 100 of about 8,062 (139)

Synaptic Vesicle Glycoprotein 2A and Epilepsy

Journal of the Japan Epilepsy Society, 2018
Ryosuke Hanaya, Hiroshi Hosoyama, Kazunori Arita   +2 more
openaire   +2 more sources

O2‐05‐01: CEREBROSPINAL FLUID SYNAPTIC VESICLE GLYCOPROTEIN 2A IN ALZHEIMER'S DISEASE [PDF]

Alzheimer's & Dementia, 2019
Nicholas J. Ashton, Kina Höglund, Antoine Leuzy, Kerstin Heurling, Jacques Hugon, Julien Dumurgier, Emmanuel Cognat, Claire Paquet, Oskar Hansson, Michael Schöll, Henrik Zetterberg, Kaj Blennow   +11 more
openaire   +1 more source

Synaptic vesicle glycoprotein 2A is affected in the CNS of Huntington’s Disease mice and post-mortem human HD brain

, 2022
Abstract: Synaptic dysfunction is a primary mechanism underlying Huntington’s Disease (HD) progression. This study investigated changes in synaptic vesicle glycoprotein 2A (SV2A) density by means of 11C-UCB-J microPET imaging in the central nervous system (CNS) of HD mice. METHODS: Dynamic 11C-UCB-J microPET imaging was performed at clinically relevant
Bertoglio, Daniele, Verhaeghe, Jeroen, Wyffels, Leonie, Miranda, Alan, Stroobants, Sigrid, Mrzljak, Ladislav, Dominguez, Celia, Skinbjerg, Mette, Bard, Jonathan, Liu, Longbin, Munoz-Sanjuan, Ignacio, Staelens, Steven   +11 more
openaire   +1 more source

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission

Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission
Synaptic vesicle glycoprotein 2A (SV2A) is a prototype synaptic vesicle protein regulating action potential-dependent neurotransmitters release. SV2A also serves as a specific binding site for certain antiepileptics and is implicated in the treatment of epilepsy.
openaire   +1 more source

Integration of postmortem amygdala expression profiling, GWAS, and functional cell culture assays: neuroticism-associated synaptic vesicle glycoprotein 2A (SV2A) gene is regulated by miR-133a and miR-218. [PDF]

Transl Psychiatry, 2020
Jurkiewicz M, Moser D, Koller A, Yu L, Chen EI, Bennett DA, Canli T.   +6 more
europepmc   +1 more source

Mass balance study of [¹⁴C]-ABBV-552, a synaptic vesicle glycoprotein 2A positive modulator, in healthy male participants following single oral dose administration. [PDF]

Eur J Clin Pharmacol
Miles N, McNamee B, Soleman SI, Zadikoff C, Boiser J, Laplanche L, Burton R, Shebley M, Boinpally RR.   +8 more
europepmc   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization. [PDF]

Aging Cell
Wang X, Zhang Q, Zhang X, Liu J, Zhang J, Liu C, Cui Y, Song Q, Hou Y, Wang Y, Cao M, Wang P.   +11 more
europepmc   +1 more source

Synaptic Terminal Density Early in the Course of Schizophrenia: an in vivo UCB-J Positron Emission Tomographic Imaging Study of Synaptic Vesicle Glycoprotein 2A (SV2A)

BackgroundThe synaptic hypothesis is an influential theory of the pathoetiology of schizophrenia (SCZ), which is supported by the finding that there is lower uptake of the synaptic terminal density marker [11C]UCB-J in patients with chronic SCZ than in control participants.
Onwordi, Ellis Chika, Whitehurst, Thomas, Shatalina, Ekaterina, Mansur, Ayla, Arumuham, Atheeshaan, Osugo, Martin, Reis Marques, Tiago, Jauhar, Sameer, Gupta, Susham, Mehrotra, Ravi, Rabiner, Eugenii A., Gunn, Roger N., Natesan, Sridhar, Howes, Oliver   +13 more
openaire   +1 more source

The relationship between synaptic vesicle glycoprotein 2A and glutamate is altered early in the course of schizophrenia

Neuroscience Applied
E.C. Onwordi, T. Whitehurst, E. Shatalina, R. Carr, A. Mansur, A. Arumuham, M. Osugo, T. Reis Marques, S. Jauhar, S. Gupta, S. Pappa, R. Mehrotra, M. Ranger, N. Rahaman, E. Rabiner, R. Gunn, S. Natesan, O. Howes   +17 more
openaire   +1 more source

Kinetic evaluation and test-retest reproducibility of [¹¹C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. [PDF]

J Cereb Blood Flow Metab, 2018
Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE.   +10 more
europepmc   +1 more source