Results 91 to 100 of about 3,985,879 (249)

HIIT-induced lactate/GPR81 signaling with dual branches converging on ERK1/2 contributes to hippocampal synaptic remodeling and memory improvement

Frontiers in Cell and Developmental Biology
The remodeling of synapses in the hippocampus is intricately linked to processes of learning and memory. Research indicates that high-intensity interval training (HIIT) enhances cognitive functions reliant on the hippocampus in mice, although the ...
Xuepeng Bian, Xuepeng Bian, Qinghui Shang, Lutao Zhu, Jun Liu, Min Wu, Jingjing Li, Shujie Lou   +7 more
doaj   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single-center cohort of 80 patients. [PDF]

Epilepsia Open
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Hecher L, Woidy M, Plein F, Bierhals T, Elsner LV, Herget T, Hempel M, Kortüm F, Grinstein L, Cramer JV, Johannsen J, Denecke J.   +11 more
europepmc   +2 more sources

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Using Hi-Spots to investigate in vitro network dysfunction in Cysteine String Protein ? knockout mice [PDF]

, 2010
Hi-Spot are highly re-aggregated neural cultures grown on PTFE membrane at the liquidair interface. The Hi-Spot protocol was developed by scientists at Capsant Neurotechnologies using embryonic neural tissue. We characterised Hi-Spots made using existing
Bailey, Joanne Louise
core   +1 more source

Tuina combined with Riluzole in amyotrophic lateral sclerosis: protocol for a randomized controlled trial with clinical outcomes and synaptic PET biomarkers

Frontiers in Neurology
BackgroundAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration, leading to severe functional decline and limited therapeutic options.
Dan Yang, Dan Yang, Dan Yang, Dan Yang, Dan Yang, Jing Zhou, Jing Zhou, Jing Zhou, Jing Zhou, Jing Zhou, Yan Zhao, Yan Zhao, Yan Zhao, Yan Zhao, Yan Zhao, Mohammad Nasb, Mohammad Nasb, Mohammad Nasb, Mohammad Nasb, Mohammad Nasb, Mohammad Nasb   +20 more
doaj   +1 more source

Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

These files contain supplemental raw data files used to analysis, and make figures.
Poppinga, Josse
core   +1 more source

Structural Disorder Provides Increased Adaptability for Vesicle Trafficking Pathways [PDF]

, 2013
Vesicle trafficking systems play essential roles in the communication between the organelles of eukaryotic cells and also between cells and their environment.
Peter Tompa, Rita Pancsa (173029), Natalia Pietrosemoli (280470), Pancsa Rita, Tompa Peter, Peter Tompa (38445), Pietrosemoli Natalia, Tompa, Péter, Rita Pancsa, Pietrosemoli, Natalia, Natalia Pietrosemoli, Pancsa, Rita   +11 more
core   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Brivaracetam: review of its pharmacology and potential use as adjunctive therapy in patients with partial onset seizures

Drug Design, Development and Therapy, 2015
Laura Mumoli,1 Caterina Palleria,2 Sara Gasparini,1 Rita Citraro,2 Angelo Labate,1 Edoardo Ferlazzo,1 Antonio Gambardella,1 Giovambattista De Sarro,2 Emilio Russo2 1Institute of Neurology, 2Institute of Pharmacology, University Magna Græcia ...
Mumoli L, Palleria C, Gasparini S, Citraro R, Labate A, Ferlazzo E, Gambardella A, De Sarro G, Russo E   +8 more
doaj  

Altered lipid peroxidation, perineuronal net and oligodendrocyte markers in the frontal cortex of a dual-hit neurodevelopmental model support its relevance to schizophrenia

Frontiers in Cellular Neuroscience
IntroductionThe pathogenesis of schizophrenia begins in early neurodevelopment and leads to an array of frontal cortical deficits. They include redox dysregulation, white matter perturbation, loss of perineuronal nets (PNNs) and reduced synaptic density.
Victoria Esuaikoh, Sarah Ibegbulam, Alistair Cook, Bianca McFarland, Nora Nunnington, Ambalangoda Perera, Jingjing Feng, Jennifer A. Cale, Madeleine V. King   +8 more
doaj   +1 more source