Results 81 to 90 of about 3,985,879 (249)

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Molecular Mechanisms of Synaptic Vesicle Degradation [PDF]

, 2016
Neurons rely on precise spatial and temporal control of neurotransmitter release to ensure proper communication. Neurotransmission occurs when synaptic vesicles in the presynaptic compartment fuse with the plasma membrane and release their contents into ...
Sheehan, Patricia Jane
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Fully Automated Azeotropic Drying-Free Synthesis of [¹⁸F]SynVesT-1 via Copper-Mediated Fluorination Using the Trasis All-in-One Module

Molecules
Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane protein expressed in presynaptic vesicles. Positron emission tomography (PET) imaging of SV2A provides an in vivo measure of synaptic density and has broad applications in the study of ...
Falguni Basuli, Jianfeng Shi, Xiang Zhang, Rolf E. Swenson   +3 more
doaj   +1 more source

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function [PDF]

, 2015
Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin.
Muhammad, K., Depner, H., Hell, S.W., Holt, Matthew, Lützkendorf, J., Loll, Bernhard, Walter, Alexander, Holt, M., Sigrist, S., Hollmann, C., Goettfert, F., Wahl, M.C., Bergeron, D.D., Goettfert, Fabian, Driller, J., Sigrist, Stephan J., Schmoranzer, J., Hell, S. ; https://orcid.org/, Muhammad, Karzan, Wahl, M., Rey, U., Goetz, Torsten, Depner, Harald, Bergeron, D., Böhme, M., Rey, Ulises, Reddy-Alla, Suneel, Holt, Mathew, Böhme, Mathias A., Driller, Jan H., Bergeron, Dominique D., Schreiner, Dietmar, Scheiffele, Peter, Walter, Alexander Matthias, Hollmann, Christina, Sigrist, S.J., Bergeron, Dominique Dufour, Walter, A., Böhme, M.A., Schmoranzer, Jan, Götz, T., Scheiffele, P., Driller, J.H., Matkovic, Tanja, Schreiner, D., Matkovic, T., Ramesh, Niraja, Lützkendorf, Janine, Hell, Stefan, Götz, Torsten, Luetzkendorf, Janine, Ramesh, N., Hell, Stefan W., Reddy-Alla, S., Walter, Alexander M., Wahl, Markus C., Göttfert, F., Reddy Alla, S., Walter, A.M., Loll, B., Rey U, Reddy-Alla S, Götz T, Wahl MC, Walter AM, Driller JH, Scheiffele P, Hell SW, Loll B, Matkovic T, Ramesh N, Schmoranzer J, Bergeron DD, Böhme MA, Hollmann C, Muhammad K, Depner H, Goettfert F, Holt M, Sigrist SJ, Lützkendorf J, Schreiner D   +81 more
core   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Cryoimmunoelectron microscopic localization of synaptic proteins in nerve terminals and astrocytic cells [PDF]

, 2004
In the present study the cryo-immunogold technique was used and optimized for investigating the ultrastructure and immunolabeling of synaptic proteins. It is evidently a suitable method for the localization of membrane proteins since the antigens are not
Zhang, Lixia
core  

Synaptic boutons sizes are tuned to best fit their physiological performances [PDF]

, 2013
To truly appreciate the myriad of events which relate synaptic function and vesicle dynamics, simulations should be done in a spatially realistic environment. This holds true in particular in order to explain as well the rather astonishing motor patterns
Dan Bucher, Alfio Grillo, Christoph Schuster, Bucher, Dan, Geiger, Romina, Grillo, Alfio, Lihao Ge, Knodel, Markus Michael, Queisser, Sean Gillian, Markus M Knodel, Romina Geiger, Ge, Lihao, Gillian Queisser, Schuster, Christoph M., Wittum, Gabriel, Gabriel Wittum   +15 more
core   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

The role of complement in synaptic degeneration

, 2012
Synapse loss is an early event of many neurodegenerative diseases including Alzheimer?s disease and Parkinson?s disease. The causes and mechanisms that underpin synapse dysfunction and degeneration are poorly understood.
Malfa, Katya
core   +1 more source