Results 211 to 220 of about 3,985,879 (249)

Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer's disease. [PDF]

EMBO J
Kapadia A, Schuhmann F, Daskin E, Walter J, Lindahl I, Rahmani N, Morrema THJ, Rozemuller AJM, Boon BDC, Pezeshkian W, Hafner AS.   +10 more
europepmc   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, Volume 100, Issue 5, Page 948-961, November 2026.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Synaptic vesicle architecture modulates α-synuclein conformation and pathogenic transitions in Parkinson's disease. [PDF]

Biosci Rep
Ranjan P.
europepmc   +1 more source

Endoplasmic Reticulum Autophagy Enhancement Alleviates Synaptic Plasticity Dysfunction and Ameliorates Cognitive Impairment in SAE Mice by Relieving STING‐Associated Inhibition of PKM2 Activity

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
In sepsis‐associated encephalopathy (SAE), enhanced micro‐ER‐phagy mediated by Sec62 facilitates the delivery of STING to lysosomes for degradation in hippocampal neurons. This process relieves STING‐mediated inhibition of PKM2 activity, which further modulates cellular energy metabolism indicators including the ATP/ADP and NAD+/NADH ratios ...
Xiaofeng Guo, Daqing Yin, Zhonghua Zhang, Yuanyuan Zhao, Yali Zhang, Ying Jiang, Zhanying Zhao, Tongwen Sun, Feihu Zhou, Xijing Zhang   +9 more
wiley   +1 more source

STX1B variant-specific synaptic dysfunction is associated with network hyperexcitability in human iPSC-derived neurons. [PDF]

EBioMedicine
Haag C, Gsell F, Vinogradov O, Oquendo MB, Liu Y, Uysal B, Löffler H, Stehle F, Klopfer F, Crönlein J, Böttcher K, Toonen RF, Muhle H, Kohl B, Lerche H, Schwarz N.   +15 more
europepmc   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer's and Parkinson's Disease. [PDF]

Cells
Cipriano GL, Anchesi I, Floramo A, Argento V, Spinelli S, Astorino MF, Calabrò M, Artimagnella O.   +7 more
europepmc   +1 more source

Tau A152T risk variant drives distinct cell type transcriptional signatures in AD and PSP. [PDF]

Acta Neuropathol
Lilley MT, Ren Y, Soni D, Sanborn EC, Marks JD, Chen Y, Yan Y, DeTure M, Rawlinson B, Dickson DW, Cook CN.   +10 more
europepmc   +1 more source

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex

Glia, Volume 74, Issue 11, November 2026.
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis, Breana C. Dogan, Amy L. Stanek, Elliot B. Evans, Madelyn G. Coble, Hayli E. Spence‐Osorio, Karen L. G. Farizatto, Angie L. Mordant, C. Allie Mills, Laura E. Herring, Katherine T. Baldwin   +10 more
wiley   +1 more source

NLGN3 autism variants have distinct functional impact on synapses and sleep behavior in Drosophila. [PDF]

PLoS Genet
Townsley RE, Andrews JC, Srivastav S, Jangam SV, Hannan SB, Kanca O, Marcogliese PC, Yamamoto S, Wangler MF.   +8 more
europepmc   +1 more source