Results 191 to 200 of about 3,985,879 (249)

Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development. [PDF]

J Cell Biol
Aiken J, Borland C, Marotta N, Prosser BL, Holzbaur ELF.   +4 more
europepmc   +1 more source

Trigeminal and facial branchiomotor neurons have shared muscle targets in zebrafish larvae

Journal of Anatomy, EarlyView.
Cranial nerve innervation map, based on previous studies, shows the trigeminal and facial motor nerves confined to the mandibular and hyoid arch muscles, respectively, except for the trigeminal nerve in the interhyoideus muscle (M.IH). The revised cranial nerve innervation map, based on this study, shows the facial nerve in the intermandibularis ...
Ritika Ghosal, Kimberly L. McArthur, Johann K. Eberhart   +2 more
wiley   +1 more source

Differential ubiquitin modifications of ESCRT‐I subunits VPS37‐1 and VPS28‐2 positively regulate plant immunity

New Phytologist, EarlyView.
The RING type ubiquitin ligase (E3), XBAT35.2, positively regulates FLS2‐mediated plant immunity against bacterial pathogens by modifying the ESCRT‐I subunits VPS28‐2 and VPS37‐1 with distinct ubiquitin chain types. Summary Sensing of pathogen‐associated molecular patterns (PAMPs) by pattern recognition receptors at the cell surface initiates the first
Chaofeng Wang, Yi Zhang, Bangjun Zhou, Pooja Verma, Lirong Zeng   +4 more
wiley   +1 more source

Sleep deprivation increases levels of the synaptic density marker SV2A in the human brain. [PDF]

PLoS Biol
Elmenhorst D, Foerges AL, Gordji-Nejad A, Elmenhorst EM, Kroll T, Matusch A, Beer S, Neumaier B, Krapf P, Lerche C, Drzezga A, Bauer A.   +11 more
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

New-Generation Antiseizure Medications: Who Takes the Lead in the Real World? [PDF]

Epilepsy Curr
Taraschenko O.
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer’s disease- associations with Aβ, tau and synaptophysin

Nussbaumer J, Barve A, Zufferey V, Espourteille J, Kirabali T, Konietzko U, Razansky D, Rominger A, Nordberg A, Buée L, Colin M, Nitsch RM, Hock C, Richetin K, Ni R.   +14 more
europepmc   +1 more source

Mapping the Synaptome in Neurodegeneration: Emerging Clinical Applications of SV2A PET Imaging. [PDF]

Mol Diagn Ther
Filippi L, Nuvoli S, Spanu A, Palumbo B.
europepmc   +1 more source