Results 101 to 110 of about 55,011 (263)

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source

Evidence for a Clathrin-independent mode of endocytosis at a continuously active sensory synapse

Frontiers in Cellular Neuroscience, 2014
Synaptic vesicle exocytosis at chemical synapses is followed by compensatory endocytosis. Multiple pathways including Clathrin-mediated retrieval of single vesicles, bulk retrieval of large cisternae, and kiss-and-run retrieval have been reported to ...
Michaela eFuchs, Johann Helmut Brandstätter, Hanna eRegus-Leidig   +2 more
doaj   +1 more source

Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells. [PDF]

, 1994
Neurons and endocrine cells have two types of secretory vesicle that undergo regulated exocytosis. Large dense core vesicles (LDCVs) store neural peptides whereas small clear synaptic vesicles store classical neurotransmitters such as acetylcholine ...
Edwards, RH, Evans, CJ, Liu, Y, Nirenberg, MJ, Pickel, VM, Schweitzer, ES   +5 more
core  

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

, 2013
Important modulatory roles have been attributed to presynaptic NMDA receptors (NMDARs) located on cerebellar interneuron terminals. Evidence supporting a presynaptic location includes an increase in the frequency of mini events following the application ...
Benton, DCH, Caldwell, M, Moss, GWJ, Robertson, AD, Smart, TG   +4 more
core   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

eLife, 2018
Synaptic vesicle fusion occurs at specialized release sites at the active zone. How refilling of release sites with new vesicles is regulated in central synapses remains poorly understood. Using nanoscale-resolution detection of individual release events
Dario Maschi, Michael W Gramlich, Vitaly A Klyachko   +2 more
doaj   +1 more source

Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]

, 2017
Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T, Berthet, Amandine, Edwards, Robert H, Manfredsson, Fredric P, Nakamura, Ken, Nguyen, Mai K, Orr, Adam L, Pathak, Divya, Sellnow, Rhyomi C, Yu, Katharine   +9 more
core   +1 more source

Molecular mechanisms in synaptic vesicle recycling [PDF]

FEBS Letters, 1995
Synaptic vesicles are specialized secretory organelles which are involved in the fast, point‐to‐point signaling typical of synapses. They store and secrete non‐peptide neurotransmitters and are continuously regenerated in nerve terminals by exoendocytotic recycling.
openaire   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling

BMC Biology, 2021
Background Maturation is a process that allows synapses to acquire full functionality, optimizing their activity to diverse neural circuits, and defects in synaptic maturation may contribute to neurodevelopmental disorders.
Andonia Petkova-Tuffy, Nina Gödecke, Julio Viotti, Martin Korte, Thomas Dresbach   +4 more
doaj   +1 more source