Results 111 to 120 of about 29,089 (240)
Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons
Traffic, Volume 27, Issue 2, June 2026.Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is poorly understood. Using live‐cell imaging to track vesicle trajectories, combined with machine learning‐based classification, the analysis reveals ...
Beatriz Aznar‐Escolano +6 more
wiley +1 more source
Optical detection of three modes of endocytosis at hippocampal synapses
eLife, 2018 Coupling of synaptic vesicle fusion and retrieval constitutes a core mechanism ensuring maintenance of presynaptic function. Recent studies using fast-freeze electron microscopy and capacitance measurements reported an ultrafast mode of endocytosis ...
Natali L Chanaday, Ege T Kavalali
doaj +1 more source
Sustained exocytosis after action potential-like stimulation at low frequencies in mouse chromaffin cells depends on a dynamin-dependent fast endocytotic process [PDF]
, 2016 Under basal conditions the action potential firing rate of adrenal chromaffin cells is lower than 0.5 Hz. The maintenance of the secretory response at such frequencies requires a continuous replenishment of releasable vesicles.
Alvarez, Yanina Daniela +7 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song +5 more
wiley +1 more source
The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. [PDF]
, 1998 We have investigated the controversial involvement of components of the SNARE (soluble N-ethyl maleimide-sensitive factor [NSF] attachment protein [SNAP] receptor) machinery in membrane traffic to the apical plasma membrane of polarized epithelial (MDCK)
Chapin, SJ +6 more
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Organic neuromorphic electronics powering intelligent sensory and edge computing systems
InfoMat, Volume 8, Issue 5, May 2026.Organic electronic materials are promising candidates for neuromorphic sensing applications, including chemical, physical, visual, and multimodal sensing, owing to their mechanical softness, biocompatibility, and intrinsic ionic–electronic coupling.
Seungjun Woo +5 more
wiley +1 more source
Live imaging of synaptic vesicle release and retrieval in dopaminergic neurons
Frontiers in Neural Circuits, 2009 Dopaminergic (DA) neurons represent less than 0.01% of neurons in the human brain, but are essential for normal neurological and psychiatric function. The majority of these neurons reside in the ventral midbrain, but they exert their profound influences ...
Meera Mani, Meera Mani, Timothy A Ryan
doaj +1 more source
Metabolism Controls the Timing of Human Brain Development and Maturation
Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.ABSTRACT Among primates the human brain is the largest in size, exhibiting a higher neuronal density and connectivity. The prolonged expansion and subsequent connectome reorganization of the human brain have been suggested to promote higher cognitive and behavioral abilities.
Valentina Rava +3 more
wiley +1 more source
Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles
eLife, 2014 Presynaptic terminals release neurotransmitters spontaneously in a manner that can be regulated by Ca2+. However, the mechanisms underlying this regulation are poorly understood because the inherent stochasticity and low probability of spontaneous fusion
Jeremy Leitz, Ege T Kavalali
doaj +1 more source
The Golgi apparatus: 100 years of progress and controversy. [PDF]
, 1998 Research on the Golgi apparatus has resulted in major advances in understanding its structure and functions, but many important questions remain unanswered.
Farquhar, MG, Palade, GE
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