Results 111 to 120 of about 55,011 (263)

Long‐Read Genome Sequencing Establishes Biallelic Pathogenic Variants in DNM1 With Distinct Functional Effects as the Cause of Early Infantile Developmental and Epileptic Encephalopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous de novo and inherited biallelic pathogenic variants in DNM1 have been reported in association with autosomal dominant (AD) and autosomal recessive (AR) developmental and epileptic encephalopathy, respectively, due to aberrant dynamin function or expression, with each inheritance pattern associated with a different mechanism of ...
Andy Drackley, Merlene Peter, Heba H. Akbari, Jelena Ivanisevic, Alexander Ing, Kelly Regan‐Fendt, Patrick McMullen, Kai Lee Yap   +7 more
wiley   +1 more source

Synaptic vesicles are primed for fast clathrin-mediated endocytosis at the ribbon synapse

Frontiers in Molecular Neuroscience, 2014
Retrieval of synaptic vesicles can occur 1-10 s after fusion, but the role of clathrin during this process has been unclear because the classical mode of clathrin-mediated endocytosis (CME) is an order of magnitude slower, as during retrieval of surface ...
Ilaria ePelassa, Ilaria ePelassa, CongJian eZhao, CongJian eZhao, Mathias ePasche, Benjamin eOdermatt, Benjamin eOdermatt, Leon eLagnado, Leon eLagnado   +8 more
doaj   +1 more source

Activity of nAChRs containing α9 subunits modulates synapse stabilization via bidirectional signaling programs [PDF]

, 2009
Although the synaptogenic program for cholinergic synapses of the neuromuscular junction is well known, little is known of the identity or dynamic expression patterns of proteins involved in non-neuromuscular nicotinic synapse development.
Elgoyhen, Ana Belen, Murthy, Vidya, Taranda, Julian, Vetter, Douglas E.   +3 more
core   +1 more source

Regulation of synaptic vesicle recycling by calcineurin in different vesicle pools [PDF]

Neuroscience Research, 2005
The synaptic vesicles keep recycling by the processes of endocytosis and exocytosis to maintain the normal synaptic transmission. The synaptic vesicles are classified as the readily releasable pool (RRP) and the reserve pool (RP). In the endocytosis process, calcineurin (CaN), a Ca2+/calmodulin-dependent protein phosphatase, has been shown to play ...
Susumu, Kumashiro, Yun-Fei, Lu, Kazuhito, Tomizawa, Masayuki, Matsushita, Fan-Yan, Wei, Hideki, Matsui   +5 more
openaire   +2 more sources

Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of STXBP1‐Related Epileptic Encephalopathy

Annals of Neurology, EarlyView.
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar1, Alexey I. Nesvizhskii, Michael D. Uhler, Jack M. Parent, Yu Wang   +7 more
wiley   +1 more source

PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exocytosis and endocytosis

Scientific Reports
Neuronal communication relies on synaptic vesicle recycling, which has long been investigated by live imaging approaches. Synapto-pHluorins, genetically encoded reporters that incorporate a pH-sensitive variant of GFP within the lumen of the synaptic ...
Svilen V. Georgiev, Silvio O. Rizzoli
doaj   +1 more source

Organic neuromorphic electronics powering intelligent sensory and edge computing systems

InfoMat, EarlyView.
Organic electronic materials are promising candidates for neuromorphic sensing applications, including chemical, physical, visual, and multimodal sensing, owing to their mechanical softness, biocompatibility, and intrinsic ionic–electronic coupling.
Seungjun Woo, Minji Chung, Hyun Woo Song, Seoyoung Kim, Eun Kwang Lee, Joon Hak Oh   +5 more
wiley   +1 more source

Platelet activating factor enhances synaptic vesicle exocytosis via PKC, elevated intracellular calcium, and modulation of synapsin 1 dynamics and phosphorylation

Frontiers in Cellular Neuroscience, 2016
Platelet activating factor (PAF) is an inflammatory phospholipid signaling molecule implicated in synaptic plasticity, learning and memory and neurotoxicity during neuroinflammation.
Jennetta W Hammond, Shao-Ming eLu, Harris A Gelbard   +2 more
doaj   +1 more source

Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation

Molecular Biology of the Cell, 2014
This is the first study to show the direct effects of α-synuclein on synaptic vesicle trafficking and to elucidate the underlying structural mechanisms. Acutely increasing α-synuclein severely inhibits synaptic vesicle recycling from the plasma membrane.
David J. Busch, P. Oliphint, Rylie B. Walsh, Susan M. L. Banks, W. Woods, J. George, J. Morgan   +6 more
semanticscholar   +1 more source

Recycling and biogenesis of synaptic vesicles

Seminars in Neuroscience, 1994
Abstract Synaptic vesicles are specialized organelles used for the fast, point-to-point signaling typical of the nervous system. Like secretory granules of the classical regulated secretory pathway, synaptic vesicles undergo exocytosis in a Ca2+-dependent fashion.
Peter S. McPherson, Pietro De Camilli
openaire   +1 more source