Results 171 to 180 of about 55,011 (263)
Efficient and rapid isolation of native AMPA receptor complexes for cryo‐EM
Protein Science, Volume 35, Issue 2, February 2026.Abstract Isolating native ion channels for structural characterization is routinely achieved by extraction from membrane fractions of tissue with prolonged mild detergent treatment. AMPA receptors (AMPARs), glutamatergic receptors that mediate fast excitatory transmission and synaptic plasticity, are coassembled with diverse auxiliary subunits and ...
Jumi Park, Eric Gouaux
wiley +1 more source
Dysfunction of synaptic endocytic trafficking in Parkinson’s disease
Neural Regeneration ResearchParkinson’s disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.
Xin Yi Ng, Mian Cao
doaj +1 more source
Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss
Aging Cell, Volume 25, Issue 2, February 2026.Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli +3 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando +7 more
wiley +1 more source
T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy
Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri +7 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 2, February 2026.Schematic diagram illustrating the communication between mouse hippocampal astrocytes and neurons through extracellular vesicles (EVs). The illustration highlights unique proteins secreted by each cell type within EVs, with vesicle size proportional to the concentration of secreted proteins.
Daria Hajka +8 more
wiley +1 more source
Spontaneous and evoked synaptic vesicle release arises from a single releasable pool
Cell ReportsSummary: The quantal content of an evoked postsynaptic response is typically determined by dividing it by the average spontaneous miniature response. However, this approach is challenged by the notion that different synaptic vesicle pools might drive ...
Junxiu Duan +3 more
doaj +1 more source
Fifty Years of Natural Killer Cells: Milestones and Future Horizons
Scandinavian Journal of Immunology, Volume 103, Issue 2, February 2026.To mark 50 years of NK cell research, a 2025 Karolinska symposium traced discoveries from spontaneous cytotoxicity and “missing self” recognition to receptor biology, cellular diversity, and translational advances, highlighting NK cells’ evolution into modern immunotherapy.
Andreas Lundqvist +7 more
wiley +1 more source
Distinct synaptic vesicle recycling in inhibitory nerve terminals is coordinated by SV2A
Progress in neurobiology, 2019 Jae Ryul Bae +6 more
semanticscholar +1 more source
Recycling of Synaptic Vesicle Membrane Components
Cold Spring Harbor Symposia on Quantitative Biology, 1995 Y, Kaneda +6 more
openaire +2 more sources