Results 71 to 80 of about 55,011 (263)

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses

Cell Reports, 2016
Synaptic transmission relies on coordinated coupling of synaptic vesicle (SV) exocytosis and endocytosis. While much attention has focused on characterizing proteins involved in SV recycling, the roles of membrane lipids and their metabolism remain ...
Hana L. Goldschmidt, Becky Tu-Sekine, Lenora Volk, Victor Anggono, Richard L. Huganir, Daniel M. Raben   +5 more
doaj   +1 more source

Synaptophysin and synaptoporin expression in the developing rat olfactory system [PDF]

, 1993
The expressions of two closely related synaptic vesicle antigens synaptophysin and synaptoporin were examined in the olfactory system of the adult rat and during pre- and postnatal development.
Bayer, Bergmann, Betz, Bixby, Breipohl, Brunjes, Elferink, Farbman, Farbman, Fletcher, Geppert, Gesteland, Graziadei, Halász, Halász, Hinds, Hsu, Huttner, Jahn, Jahn, Knaus, Kosaka, Lahr, Lahr, Leube, Mandell, Marchand, Margolis, Marquèze-Pouey, Matteoli, McLean, Navone, Ovtscharoff, Pedersen, Rehn, Schwob, Schwob, Shipley, Smotherman, Specht, Specht, Südhof, Thomas, Thomas, Tixier-Vidal, Trimble, Van Lookeren Campagne, Verhaagen, Wendland, Wiedenmann, Zhong   +50 more
core   +1 more source

Ultrastructural and functional fate of recycled vesicles in hippocampal synapses [PDF]

, 2015
Efficient recycling of synaptic vesicles is thought to be critical for sustained information transfer at central terminals. However, the specific contribution that retrieved vesicles make to future transmission events remains unclear.
A Denker, A Denker, A Denker, A Ratnayaka, A Ratnayaka, AA Alabi, AW Henkel, AW Henkel, B Granseth, C Rosenmund, D Kamin, DM Ramirez, EA Lemke, FE Schweizer, G Miesenbock, H Park, J Raingo, JL Pyle, K Staras, KJ Darcy, KJ Darcy, M Bal, M Ertunc, M Frerking, MA Colicos, MA Gaffield, MW Fowler, N Harata, O Shupliakov, RP de Lange, S Sankaranarayanan, S Sankaranarayanan, S Tsuriel, S Watanabe, S Watanabe, SO Rizzoli, SO Rizzoli, SS Zakharenko, T Schikorski, T Schikorski, TA Ryan, TA Ryan, TC Sudhof, V Marra, V Marra, V Westphal, WJ Betz, Y Hua, Y Sara, Y Zhu, Z Hua, Z Li   +51 more
core   +6 more sources

Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]

, 1993
The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna, Meyerowitz, Elliot M., Redelmeier, Thomas E., Schmid, Sandra L., Tisdale, Ellen J., van der Bliek, Alexander M.   +5 more
core   +3 more sources

Sensing Exocytosis and Triggering Endocytosis at Synapses: Synaptic Vesicle Exocytosis–Endocytosis Coupling

Frontiers in Cellular Neuroscience, 2018
The intact synaptic structure is critical for information processing in neural circuits. During synaptic transmission, rapid vesicle exocytosis increases the size of never terminals and endocytosis counteracts the increase. Accumulating evidence suggests
Xuelin Lou
doaj   +1 more source

UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans. [PDF]

PLoS ONE, 2012
The recycling of synaptic vesicles requires the recovery of vesicle proteins and membrane. Members of the stonin protein family (Drosophila Stoned B, mammalian stonin 2) have been shown to link the synaptic vesicle protein synaptotagmin to the endocytic ...
Gregory P Mullen, Kiely M Grundahl, Mingyu Gu, Shigeki Watanabe, Robert J Hobson, John A Crowell, John R McManus, Eleanor A Mathews, Erik M Jorgensen, James B Rand   +9 more
doaj   +1 more source

A Mathematical Model of Tripartite Synapse: Astrocyte Induced Synaptic Plasticity

, 2012
In this paper we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and ...
Majumdar, Kaushik, Tewari, Shivendra
core   +1 more source

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]

, 2006
Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium.
A. Scheuber, Blagoveshchenskaya, Dell'Angelica, Fa  ndez, G. Raposo, Goda, Guti  rrez, Hayashi, J.-C. Poncer, Kamiya, Kantheti, L. Danglot, Li, Lopantsev, Musleh, Muzerelle, R. Rudge, Rizzoli, Rosenmund, Sakaba, Schoch, Sj  str  m, Stobrawa, Stoppini, Sudhof, Sugita, Sugita, T. Binz, T. Galli, Takei, Vogt, Woodhall, Xu   +32 more
core   +6 more sources

Tyrosine phosphorylation of synaptophysin in synaptic vesicle recycling [PDF]

Biochemical Society Transactions, 2005
The integral SV (synaptic vesicle) protein synaptophysin was one of the first nerve terminal proteins identified. However its role, if any, in the SV life cycle remains undetermined. One of the most prominent features of synaptophysin is that its cytoplasmic C-terminus largely consists of pentapeptide repeats initiated by a tyrosine residue ...
G J O, Evans, M A, Cousin
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source