LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision
Cell Reports, 2019 Summary: Classical fast neurotransmitters are loaded into synaptic vesicles and concentrated by the action of a specific vesicular transporter before being released from the presynaptic neuron.
Ying Xu, Tao Wang
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Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function [PDF]
, 2017 Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are responsible ...
Goutman, Juan Diego
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Storage and Uptake of d-Serine into Astrocytic Synaptic-Like Vesicles Specify Gliotransmission
Journal of Neuroscience, 2013 Glial cells are increasingly recognized as active players that profoundly influence neuronal synaptic transmission by specialized signaling pathways. In particular, astrocytes have been shown recently to release small molecules, such as the amino acids l-
M. Martineau +9 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu +21 more
wiley +1 more source
Histamine synthesis and transport are coupled in axon terminals via a dual quality control system
The EMBO JournalMonoamine neurotransmitters generated by de novo synthesis are rapidly transported and stored into synaptic vesicles at axon terminals. This transport is essential both for sustaining synaptic transmission and for limiting the toxic effects of monoamines.
Lei Peng, Tao Wang
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The readily-releasable pool dynamically regulates multivesicular release
eLife, 2019 The number of neurotransmitter-filled vesicles released into the synaptic cleft with each action potential dictates the reliability of synaptic transmission.
Jada H Vaden +4 more
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Medial Superior Olivary Neurons Receive Surprisingly Few Excitatory and Inhibitory Inputs with Balanced Strength and Short-Term Dynamics [PDF]
, 2010 Neurons in the medial superior olive (MSO) process microsecond interaural time differences, the major cue for localizing low-frequency sounds, by comparing the relative arrival time of binaural, glutamatergic excitatory inputs. This coincidence detection
Couchman, Kiri +2 more
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Metabolic Regulation of Single Synaptic Vesicle Exo- and Endocytosis in Hippocampal Synapses [PDF]
, 2023 Jongyun Myeong +3 more
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Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Advanced Materials, EarlyView.Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
wiley +1 more source
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023 Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
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