Results 31 to 40 of about 549,591 (370)

Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals [PDF]

, 2012
Presynaptic terminals are specialized sites for information transmission where vesicles fuse with the plasma membrane and are locally recycled. Recent work has extended this classical view, with the observation that a subset of functional vesicles is ...
Burden, Jemima J, Gitler, Daniel, Kahn, Joy, Lavy, Yotam, Marra, Vincenzo, Orenbuch, Ayelet, Shalev, Lee, Sinai, Isaac, Staras, Kevin   +8 more
core   +1 more source

Counting the Number of Glutamate Molecules in Single Synaptic Vesicles.

Journal of the American Chemical Society, 2019
Analytical tools for quantitative measurements of glutamate, the principal excitatory neurotransmitter in brain, are lacking. Here, we introduce a new enzyme-based amperometric sensor tech-nique for counting of glutamate molecules stored inside single ...
Yuanmo Wang, H. Fathali, D. Mishra, T. Olsson, Jacqueline D. Keighron, K. Skibicka, A. Cans   +6 more
semanticscholar   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses

Cells, 2023
Ribbon synapses reliably transmit synaptic signals over a broad signalling range. Rod photoreceptor ribbon synapses are capable of transmitting signals generated by the absorption of single photons.
Alina Dittrich, Girish Ramesh, Martin Jung, Frank Schmitz   +3 more
doaj   +1 more source

Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. [PDF]

, 1981
Two different monoclonal antibodies, characterized initially as binding synaptic terminal regions of rat brain, bind a 65,000-dalton protein, which is exposed on the outer surface of brain synaptic vesicles. Immunocytochemical experiments at the electron
Matthew, WD, Reichardt, LF, Tsavaler, L
core   +2 more sources

Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex

Frontiers in Synaptic Neuroscience, 2018
Cortical computations rely on functionally diverse and highly dynamic synapses. How their structural composition affects synaptic transmission and plasticity and whether they support functional diversity remains rather unclear.
Astrid Rollenhagen, Ora Ohana, Kurt Sätzler, Claus C. Hilgetag, Dietmar Kuhl, Joachim H. R. Lübke, Joachim H. R. Lübke, Joachim H. R. Lübke   +7 more
doaj   +1 more source

Analysis of shape and spatial interaction of synaptic vesicles using data from focused ion beam scanning electron microscopy (FIB-SEM)

Frontiers in Neuroanatomy, 2015
The spatial interactions of synaptic vesicles in synapses were assessed after a detailed characterization of size, shape, and orientation of the synaptic vesicles.
Mahdieh eKhanmohammadi, Rasmus eWaagepetersen, Jon eSporring   +2 more
doaj   +1 more source

Localization and mobility of synaptic vesicles in Myosin VI mutants of Drosophila. [PDF]

PLoS ONE, 2014
BACKGROUND: At the Drosophila neuromuscular junction (NMJ), synaptic vesicles are mobile; however, the mechanisms that regulate vesicle traffic at the nerve terminal are not fully understood.
Marta Kisiel, Kristopher McKenzie, Bryan Stewart   +2 more
doaj   +1 more source

Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]

, 2016
The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni, Dallérac, Glenn, Davies, Heather A., Doyère, Valérie, Kraev, Igor V., Stewart, Michael G.   +5 more
core   +1 more source

Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease

Nature Communications, 2017
Autophagy-mediated degradation of synaptic components maintains synaptic homeostasis but also constitutes a mechanism of neurodegeneration. It is unclear how autophagy of synaptic vesicles and components of presynaptic active zones is regulated. Here, we
Patrick Lüningschrör, Beyenech Binotti, Benjamin Dombert, P. Heimann, Á. Pérez-Lara, Carsten Slotta, N. Thau-Habermann, Cora R. von Collenberg, Franziska Karl, M. Damme, Arie Horowitz, I. Maystadt, A. Füchtbauer, E. Füchtbauer, S. Jablonka, R. Blum, N. Üçeyler, S. Petri, B. Kaltschmidt, R. Jahn, C. Kaltschmidt, M. Sendtner   +21 more
semanticscholar   +1 more source