Results 41 to 50 of about 549,591 (370)
Frontiers in Cellular Neuroscience, 2023 The Drosophila larval neuromuscular junction (NMJ) is a well-known model system and is often used to study synapse development. Here, we show synaptic degeneration at NMJ boutons, primarily based on transmission electron microscopy (TEM) studies.
Gan Guangming +10 more
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Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
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Spontaneous Vesicle Recycling in the Synaptic Bouton
Frontiers in Cellular Neuroscience, 2014 The trigger for synaptic vesicle exocytosis is Ca2+, which enters the synaptic bouton following action potential stimulation. However, spontaneous release of neurotransmitter also occurs in the absence of stimulation in virtually all synaptic boutons. It
Sven eTruckenbrodt +4 more
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Protocol for Quantitative Analysis of Synaptic Vesicle Clustering in Axons of Cultured Neurons
STAR Protocols, 2020 Summary: Clustering of synaptic vesicles along the neuronal axons is a critical mechanism underpinning proper synaptic transmission. Here, we provide a detailed protocol for analyzing the distribution of synaptic vesicles in presynaptic boutons of ...
Ji Won Um +3 more
doaj +1 more source
Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction [PDF]
, 2017 Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic anhydrase (CA), an enzyme that regulates pH inside and outside cells.
Bertone Cueto, Nicolás Iván +5 more
core +1 more source
Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]
, 2012 BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Alifragis, P +5 more
core +6 more sources
Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression
Cell Reports, 2018 Summary: Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a ...
Manami Yamashita +3 more
doaj +1 more source
Journal of Neuroscience, 2016 Synaptic transmission between neurons requires precise management of synaptic vesicles. While individual molecular components of the presynaptic terminal are well known, exactly how the molecules are organized into a molecular machine serving the storage
A. A. Cole, Xiaobing Chen, T. Reese
semanticscholar +1 more source
The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
Translational Neurodegeneration, 2021 Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain. Synaptic dysfunction, an important pathological hallmark
Moxin Wu +8 more
semanticscholar +1 more source
Journal of Neuroscience, 2016 Homeostatic regulation is essential for the maintenance of synaptic strength within the physiological range. The current study is the first to demonstrate that both induction and reversal of homeostatic upregulation of synaptic vesicle release can occur ...
Xueyong Wang, M. Pinter, M. Rich
semanticscholar +1 more source