Results 41 to 50 of about 65,541 (146)
Synaptic Vesicles Dynamics in Neocortical Epilepsy
Frontiers in Cellular Neuroscience, 2020 Neuronal hyperexcitability often results from an unbalance between excitatory and inhibitory neurotransmission, but the synaptic alterations leading to enhanced seizure propensity are only partly understood.
Eleonora Vannini +8 more
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Research progress on vesicle cycle and neurological disorders
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Neurons are special polarized cells whose synaptic vesicles release neurotransmitters into the synaptic cleft, acting on postsynaptic receptors and thus transmitting information from presynaptic to postsynaptic states.
Chengcheng Zhang, Li-Juan Zhu, Ce Chen
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The GTPase Rab26 links synaptic vesicles to the autophagy pathway
eLife, 2015 Small GTPases of the Rab family not only regulate target recognition in membrane traffic but also control other cellular functions such as cytoskeletal transport and autophagy.
Beyenech Binotti +11 more
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Use of fluorescent probes to follow membrane traffic in nerve terminals
Brazilian Journal of Medical and Biological Research, 1998 Optical tracers in conjunction with fluorescence microscopy have become widely used to follow the movement of synaptic vesicles in nerve terminals. The present review discusses the use of these optical methods to understand the regulation of exocytosis ...
Guatimosim C. +3 more
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Frontiers in Cellular Neuroscience, 2014 ClC-3 is a member of the CLC family of anion channels and transporters that localizes to early and late endosomes as well as to synaptic vesicles. Its genetic disruption in mouse models results in pronounced hippocampal and retinal neurodegeneration ...
Raul Enrique Guzman +5 more
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Cell & Bioscience, 2020 Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity.
Xianchao Du +8 more
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Nature Communications, 2017 During neurotransmission synaptic vesicles are filled with glutamate by vesicular glutamate transporters (VGLUTs). Here, authors image intact neurons and show that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a ...
Magalie Martineau +3 more
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Histamine synthesis and transport are coupled in axon terminals via a dual quality control system
The EMBO JournalMonoamine neurotransmitters generated by de novo synthesis are rapidly transported and stored into synaptic vesicles at axon terminals. This transport is essential both for sustaining synaptic transmission and for limiting the toxic effects of monoamines.
Lei Peng, Tao Wang
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LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision
Cell Reports, 2019 Summary: Classical fast neurotransmitters are loaded into synaptic vesicles and concentrated by the action of a specific vesicular transporter before being released from the presynaptic neuron.
Ying Xu, Tao Wang
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The readily-releasable pool dynamically regulates multivesicular release
eLife, 2019 The number of neurotransmitter-filled vesicles released into the synaptic cleft with each action potential dictates the reliability of synaptic transmission.
Jada H Vaden +4 more
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