Synaptonemal Complex in Human Biology and Disease [PDF]
Cells, 2023 The synaptonemal complex (SC) is a meiosis-specific multiprotein complex that forms between homologous chromosomes during prophase of meiosis I. Upon assembly, the SC mediates the synapses of the homologous chromosomes, leading to the formation of ...
Elena Llano, Alberto M. Pendás
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Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. [PDF]
PLoS Genetics, 2010 Meiosis is unique to germ cells and essential for reproduction. During the first meiotic division, homologous chromosomes pair, recombine, and form chiasmata.
Yong-Hyun Shin +8 more
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Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex [PDF]
Life Science Alliance, 2023 Exchanges between DNA molecules during meiosis are tightly controlled. This work shows that the synaptonemal complex is instrumental in regulating meiotic exchanges both between the parental chromosomes and between the sister chromatids.
David E Almanzar +6 more
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Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images [PDF]
Frontiers in Cell and Developmental Biology, 2023 During the formation of ova and sperm, homologous chromosomes get physically attached through the synaptonemal complex and exchange DNA at crossover sites by a process known as meiotic recombination.
Joaquim Soriano +3 more
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Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish [PDF]
Frontiers in Genetics, 2023 Introduction: The correct pairing and separation of homologous chromosomes during meiosis is crucial to ensure both genetic stability and genetic diversity within species. In allodiploid organisms, synapsis often fails, leading to sterility.
Jing Wang +10 more
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FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis [PDF]
iScience, 2022 Summary: Meiotic prophase I is a prolonged G2 phase that ensures the completion of numerous meiosis-specific chromosome events. During meiotic prophase I, homologous chromosomes undergo synapsis to facilitate meiotic recombination yielding crossovers. It
Nobuhiro Tanno +8 more
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Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida [PDF]
Open Biology, 2021 Chromosome segregation in eukaryotes is driven by the kinetochore, a macromolecular complex that connects centromeric DNA to microtubules of the spindle apparatus.
Eelco C. Tromer +4 more
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Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex [PDF]
Journal of Developmental BiologyFemale gametogenesis is orchestrated by dynamic epigenetic modifications. In mammals, SETDB1, a histone H3K9 methyltransferase, is required for proper meiotic progression and early embryonic development.
Brigite Cabrita +2 more
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Unconventional conservation reveals structure-function relationships in the synaptonemal complex [PDF]
eLife, 2021 Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged ...
Lisa E Kursel, Henry D Cope, Ofer Rog
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Synaptonemal complex analysis of the sex bivalent in goats [PDF]
Genetics Selection Evolution, 1994 Synaptonemal complex (SC) analysis of XY pairing in the goat (Capra hircus; 2n = 60) was investigated by electron microscopy for the first time in this species.
Amaral MEJ, Jorge W
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