Synaptonemal Complex in Human Biology and Disease [PDF]
Cells, 2023 The synaptonemal complex (SC) is a meiosis-specific multiprotein complex that forms between homologous chromosomes during prophase of meiosis I. Upon assembly, the SC mediates the synapses of the homologous chromosomes, leading to the formation of ...
Elena Llano, Alberto M. Pendás
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Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images [PDF]
Frontiers in Cell and Developmental Biology, 2023 During the formation of ova and sperm, homologous chromosomes get physically attached through the synaptonemal complex and exchange DNA at crossover sites by a process known as meiotic recombination.
Joaquim Soriano +3 more
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Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish [PDF]
Frontiers in Genetics, 2023 Introduction: The correct pairing and separation of homologous chromosomes during meiosis is crucial to ensure both genetic stability and genetic diversity within species. In allodiploid organisms, synapsis often fails, leading to sterility.
Jing Wang +10 more
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Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis. [PDF]
BioessaysThe synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Gold AL, Kim Y.
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FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis [PDF]
iScience, 2022 Summary: Meiotic prophase I is a prolonged G2 phase that ensures the completion of numerous meiosis-specific chromosome events. During meiotic prophase I, homologous chromosomes undergo synapsis to facilitate meiotic recombination yielding crossovers. It
Nobuhiro Tanno +8 more
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Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida [PDF]
Open Biology, 2021 Chromosome segregation in eukaryotes is driven by the kinetochore, a macromolecular complex that connects centromeric DNA to microtubules of the spindle apparatus.
Eelco C. Tromer +4 more
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Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex [PDF]
Journal of Developmental BiologyFemale gametogenesis is orchestrated by dynamic epigenetic modifications. In mammals, SETDB1, a histone H3K9 methyltransferase, is required for proper meiotic progression and early embryonic development.
Brigite Cabrita +2 more
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Unconventional conservation reveals structure-function relationships in the synaptonemal complex [PDF]
eLife, 2021 Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged ...
Lisa E Kursel, Henry D Cope, Ofer Rog
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Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage [PDF]
Nature Communications, 2022 During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via ...
Stéphanie Durand +6 more
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Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 [PDF]
Communications Biology, 2021 Sandhu et al. report that the synaptonemal complex (SC) protein, TEX12, localises to centrosomes independently of the SC during meiosis. They also show that it provokes centrosome amplification in somatic cells, a pathology associated with cancer ...
Sumit Sandhu +8 more
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