Synaptonemal Complex in Human Biology and Disease [PDF]
Cells, 2023 The synaptonemal complex (SC) is a meiosis-specific multiprotein complex that forms between homologous chromosomes during prophase of meiosis I. Upon assembly, the SC mediates the synapses of the homologous chromosomes, leading to the formation of ...
Elena Llano, Alberto M. Pendás
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Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida [PDF]
Open Biology, 2021 Chromosome segregation in eukaryotes is driven by the kinetochore, a macromolecular complex that connects centromeric DNA to microtubules of the spindle apparatus.
Eelco C. Tromer +4 more
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A first genetic portrait of synaptonemal complex variation. [PDF]
PLoS Genetics, 2019 The synaptonemal complex (SC) is a proteinaceous scaffold required for synapsis and recombination between homologous chromosomes during meiosis. Although the SC has been linked to differences in genome-wide crossover rates, the genetic basis of standing ...
Richard J Wang +3 more
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Coupling crossover and synaptonemal complex in meiosis. [PDF]
Genes Dev, 2022 In this Outlook, Grey and de Massy discuss a study by Pyatnitskaya et al. in this issue of Genes & Development that highlights the central role of the Saccharomyces cerevisiae ZMM protein Zip4 in how crossover formation and synapsis initiation are linked.
Grey C, de Massy B.
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Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage [PDF]
Nature Communications, 2022 During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via ...
Stéphanie Durand +6 more
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Unconventional conservation reveals structure-function relationships in the synaptonemal complex [PDF]
eLife, 2021 Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged ...
Lisa E Kursel, Henry D Cope, Ofer Rog
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Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 [PDF]
Communications Biology, 2021 Sandhu et al. report that the synaptonemal complex (SC) protein, TEX12, localises to centrosomes independently of the SC during meiosis. They also show that it provokes centrosome amplification in somatic cells, a pathology associated with cancer ...
Sumit Sandhu +8 more
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Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis. [PDF]
PLoS Genetics, 2021 During sexual reproduction the parental homologous chromosomes find each other (pair) and align along their lengths by integrating local sequence homology with large-scale contiguity, thereby allowing for precise exchange of genetic information.
Spencer G Gordon +3 more
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Skp1 proteins are structural components of the synaptonemal complex in <i>C. elegans</i>. [PDF]
Sci Adv, 2023 The synaptonemal complex (SC) is a hallmark of meiotic prophase that plays a crucial role in regulating crossovers between homologous chromosomes. Here, we demonstrate that two Skp1-related proteins in C.
Blundon JM +7 more
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Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images [PDF]
Frontiers in Cell and Developmental Biology, 2023 During the formation of ova and sperm, homologous chromosomes get physically attached through the synaptonemal complex and exchange DNA at crossover sites by a process known as meiotic recombination.
Joaquim Soriano +3 more
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