Coupling crossover and synaptonemal complex in meiosis [PDF]
Genes Dev, 2022 In this Outlook, Grey and de Massy discuss a study by Pyatnitskaya et al. in this issue of Genes & Development that highlights the central role of the Saccharomyces cerevisiae ZMM protein Zip4 in how crossover formation and synapsis initiation are linked.
C. Grey, B. de Massy
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Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images [PDF]
Frontiers in Cell and Developmental Biology, 2023 During the formation of ova and sperm, homologous chromosomes get physically attached through the synaptonemal complex and exchange DNA at crossover sites by a process known as meiotic recombination.
Joaquim Soriano +3 more
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Alterations in synaptonemal complex coding genes and human infertility [PDF]
Int J Biol Sci, 2022 About 10% of reproductive-aged couples suffer from infertility. However, the genetic causes of human infertility cases are largely unknown. Meiosis produces haploid gametes for fertilization and errors in meiosis are associated with human infertility in ...
Fengguo Zhang, Mengfei Liu, Jinmin Gao
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Sex in Symbiodiniaceae dinoflagellates: genomic evidence for independent loss of the canonical synaptonemal complex [PDF]
Scientific Reports, 2020 Dinoflagellates of the Symbiodiniaceae family encompass diverse symbionts that are critical to corals and other species living in coral reefs. It is well known that sexual reproduction enhances adaptive evolution in changing environments.
Sarah Shah +3 more
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The organization, regulation, and biological functions of the synaptonemal complex [PDF]
Asian J Androl, 2021 The synaptonemal complex (SC) is a meiosis-specific proteinaceous macromolecular structure that assembles between paired homologous chromosomes during meiosis in various eukaryotes. The SC has a highly conserved ultrastructure and plays critical roles in
Fengguo Zhang +2 more
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The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Meiotic recombination promotes genetic diversity by shuffling parental chromosomes. As observed by the very first geneticists, crossovers inhibit the formation of another crossover nearby, an elusive phenomenon called crossover interference.
Laia Capilla-Pérez +8 more
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Diffusion within the synaptonemal complex can account for signal transduction along meiotic chromosomes [PDF]
Mol Biol CellMeiotic chromosomes efficiently transduce information along their length to regulate the distribution of genetic exchanges within and between chromosomes. However, the mode of signal transduction remains unknown.
Lexy von Diezmann, Chloe Bristow, O. Rog
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The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly [PDF]
Genes Dev, 2021 Meiotic recombination is triggered by programmed double-strand breaks (DSBs), a subset of these being repaired as crossovers, promoted by eight evolutionarily conserved proteins, named ZMM.
A. Pyatnitskaya +4 more
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PLoS Genetics, 2020 Meiotic recombination is essential for faithful segregation of homologous chromosomes during gametogenesis. The progression of recombination is associated with dynamic changes in meiotic chromatin structures.
Kazumasa Takemoto +6 more
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Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish [PDF]
Frontiers in Genetics, 2023 Introduction: The correct pairing and separation of homologous chromosomes during meiosis is crucial to ensure both genetic stability and genetic diversity within species. In allodiploid organisms, synapsis often fails, leading to sterility.
Jing Wang +10 more
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