Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage [PDF]
Nature Communications, 2022 During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via ...
Stéphanie Durand +6 more
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Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 [PDF]
Communications Biology, 2021 Sandhu et al. report that the synaptonemal complex (SC) protein, TEX12, localises to centrosomes independently of the SC during meiosis. They also show that it provokes centrosome amplification in somatic cells, a pathology associated with cancer ...
Sumit Sandhu +8 more
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SCF Cdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis [PDF]
Life Science Alliance, 2021 During meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCF Cdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly.
Zhihui Zhu +3 more
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Kinetic analysis of synaptonemal complex dynamics during meiosis of yeast Saccharomyces cerevisiae reveals biphasic growth and abortive disassembly [PDF]
Frontiers in Cell and Developmental Biology, 2023 The synaptonemal complex (SC) is a dynamic structure formed between chromosomes during meiosis which stabilizes and supports many essential meiotic processes such as pairing and recombination. In budding yeast, Zip1 is a functionally conserved element of
Michael G. Pollard +4 more
doaj +2 more sources
Diversification and recurrent adaptation of the synaptonemal complex in Drosophila. [PDF]
PLoS GeneticsThe synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical structure where
Rana Zakerzade +9 more
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Correction: Synaptonemal & CO analyzer: a tool for synaptonemal complex and crossover analysis in immunofluorescence images [PDF]
Frontiers in Cell and Developmental BiologyJoaquim Soriano +3 more
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Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex [PDF]
Protein & Cell, 2017 Jianrong Feng +8 more
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Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis. [PDF]
BioessaysThe synaptonemal complex (SC) is a conserved protein structure that assembles between homologous chromosomes during meiosis. Here, we review pathways promoting homologous synapsis across model organisms, examining coordination with homolog pairing and recombination, spatiotemporal regulation of SC assembly, and the conserved molecular modules coupling ...
Gold AL, Kim Y.
europepmc +2 more sources
Cytological analysis of MRE11 protein during early meiotic prophase I in Arabidopsis and tomato [PDF]
, 2008 Early recombination nodules (ENs) are multiprotein complexes that are thought to be involved in synapsis and recombination, but little is known about their components or how they may be involved in these events. In this study, we describe the cytological
Anderson, L.K. +6 more
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Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. [PDF]
PLoS Genetics, 2012 Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown.
C Gaston Bisig +6 more
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