Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish [PDF]
Frontiers in Genetics, 2023 Introduction: The correct pairing and separation of homologous chromosomes during meiosis is crucial to ensure both genetic stability and genetic diversity within species. In allodiploid organisms, synapsis often fails, leading to sterility.
Jing Wang +10 more
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FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis [PDF]
iScience, 2022 Summary: Meiotic prophase I is a prolonged G2 phase that ensures the completion of numerous meiosis-specific chromosome events. During meiotic prophase I, homologous chromosomes undergo synapsis to facilitate meiotic recombination yielding crossovers. It
Nobuhiro Tanno +8 more
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Synaptonemal Complex Central Region Proteins Promote Localization of Pro-crossover Factors to Recombination Events During Caenorhabditis elegans Meiosis [PDF]
Genetics, 2019 Errors during meiosis are the leading cause of birth defects and miscarriages in humans. Thus, the coordinated control of meiotic events is critical for the faithful inheritance of the genome with each generation...
Cori K. Cahoon +2 more
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Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex [PDF]
Journal of Developmental BiologyFemale gametogenesis is orchestrated by dynamic epigenetic modifications. In mammals, SETDB1, a histone H3K9 methyltransferase, is required for proper meiotic progression and early embryonic development.
Brigite Cabrita +2 more
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Synaptonemal complex proteins modulate the level of genome integrity in cancers. [PDF]
Cancer Sci, 2021 The synaptonemal complex (SC) is a proteinaceous structure that is transiently formed during meiosis to promote homologous recombination between maternal and paternal chromosomes. As this structure is required only for meiotic recombination, the proteins
Hosoya N, Miyagawa K.
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SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56. [PDF]
J Cell Biol, 2021 The synaptonemal complex promotes faithful exchanges between homologous chromosomes during meiosis. Barbosa et al show that SCF-FBxo42 is important for assembly and maintenance of the synaptonemal complex by restricting the phosphatase PP2A-B56 level.
Barbosa P +6 more
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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2018 Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1
Qianyan Li +8 more
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SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis. [PDF]
Life Sci Alliance, 2021 During meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCFCdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly. Homologous chromosomes pair with each other during meiosis,
Zhu Z +3 more
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Involvement of synaptonemal complex proteins in sex chromosome segregation during marsupial male meiosis. [PDF]
PLoS Genetics, 2006 Marsupial sex chromosomes break the rule that recombination during first meiotic prophase is necessary to ensure reductional segregation during first meiotic division.
Jesús Page +9 more
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A molecular model for self-assembly of the synaptonemal complex protein SYCE3 [PDF]
Journal of Biological Chemistry, 2019 The synaptonemal complex (SC) is a supramolecular protein assembly that mediates homologous chromosome synapsis during meiosis. This zipper-like structure assembles in a continuous manner between homologous chromosome axes, enforcing a 100-nm separation ...
Orla M. Dunne, Owen R. Davies
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