The novel synaptonemal complex central element SCEP3 interlinks synapsis initiation and crossover formation in Arabidopsis thaliana [PDF]
Heckmann S +10 more
europepmc +2 more sources
Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. [PDF]
PLoS Genetics, 2010 Meiosis is unique to germ cells and essential for reproduction. During the first meiotic division, homologous chromosomes pair, recombine, and form chiasmata.
Yong-Hyun Shin +8 more
doaj +1 more source
PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis. [PDF]
Mol Biol Cell, 2022 Wellard SR +4 more
europepmc +3 more sources
Meiosis in mice without a synaptonemal complex. [PDF]
PLoS ONE, 2011 The synaptonemal complex (SC) promotes fusion of the homologous chromosomes (synapsis) and crossover recombination events during meiosis. The SC displays an extensive structural conservation between species; however, a few organisms lack SC and execute ...
Anna Kouznetsova +3 more
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Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. [PDF]
PLoS Genetics, 2012 Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown.
C Gaston Bisig +6 more
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Involvement of synaptonemal complex proteins in sex chromosome segregation during marsupial male meiosis. [PDF]
PLoS Genetics, 2006 Marsupial sex chromosomes break the rule that recombination during first meiotic prophase is necessary to ensure reductional segregation during first meiotic division.
Jesús Page +9 more
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Heterogeneity in conservation of multifunctional partner enzymes with meiotic importance, CDK2 kinase and BRCA1 ubiquitin ligase [PDF]
PeerJ, 2021 The evolution of proteins can be accompanied by changes not only to their amino acid sequences, but also their structural and spatial molecular organization.
Sergey Matveevsky, Tatiana Grishaeva
doaj +2 more sources
Crystal Structure of C-Terminal Coiled-Coil Domain of SYCP1 Reveals Non-Canonical Anti-Parallel Dimeric Structure of Transverse Filament at the Synaptonemal Complex. [PDF]
PLoS ONE, 2016 The synaptonemal complex protein 1 (SYCP1) is the main structural element of transverse filaments (TFs) of the synaptonemal complex (SC), which is a meiosis-specific complex structure formed at the synapse of homologue chromosomes to hold them together ...
Eun Kyung Seo +4 more
doaj +1 more source
Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip
Communications Biology, 2022 The X-ray crystal structures of C-terminal mutants of the coiled-coil protein cancer testis antigen TEX12 in combination with modeling of the TEX12 wild-type dimer reveal the protein’s control of its oligomeric state, which resembles assembly of its ...
James M. Dunce +2 more
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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2018 Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1
Qianyan Li +8 more
doaj +1 more source