Heterogeneity in conservation of multifunctional partner enzymes with meiotic importance, CDK2 kinase and BRCA1 ubiquitin ligase [PDF]
PeerJ, 2021 The evolution of proteins can be accompanied by changes not only to their amino acid sequences, but also their structural and spatial molecular organization.
Sergey Matveevsky, Tatiana Grishaeva
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Crystal Structure of C-Terminal Coiled-Coil Domain of SYCP1 Reveals Non-Canonical Anti-Parallel Dimeric Structure of Transverse Filament at the Synaptonemal Complex. [PDF]
PLoS ONE, 2016 The synaptonemal complex protein 1 (SYCP1) is the main structural element of transverse filaments (TFs) of the synaptonemal complex (SC), which is a meiosis-specific complex structure formed at the synapse of homologue chromosomes to hold them together ...
Eun Kyung Seo +4 more
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Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip
Communications Biology, 2022 The X-ray crystal structures of C-terminal mutants of the coiled-coil protein cancer testis antigen TEX12 in combination with modeling of the TEX12 wild-type dimer reveal the protein’s control of its oligomeric state, which resembles assembly of its ...
James M. Dunce +2 more
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Ipl1/aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis [PDF]
, 2013 Cells coordinate spindle formation with DNA repair and morphological modifications to chromosomes prior to their segregation to prevent cell division with damaged chromosomes.
A Hochwagen +51 more
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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2018 Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1
Qianyan Li +8 more
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A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]
, 2019 The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema +10 more
core +4 more sources
PLoS Genetics, 2009 In mammals, the synaptonemal complex is a structure required to complete crossover recombination. Although suggested by cytological work, in vivo links between the structural proteins of the synaptonemal complex and the proteins of the recombination ...
Ewelina Bolcun-Filas +7 more
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Ultrastructural analysis of chromatin in meiosis I plus II of rye (Secale cereale L.) [PDF]
, 2004 Scanning electron microscopy (SEM) proves to be an appropriate technique for imaging chromatin organization in meiosis I and II of rye (Secale cereale) down to a resolution of a few nanometers.
Herrmann, Reinhold G. +3 more
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A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori
G3: Genes, Genomes, Genetics, 2023 Meiosis is usually described as 4 essential and sequential processes: (1) homolog pairing; (2) synapsis, mediated by the synaptonemal complex; (3) crossing over; and (4) segregation.
Youbin Xiang +9 more
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A BIRD´S-EYE VIEW OF CHROMOSOMES DURING MEIOTIC PROPHASE I [PDF]
BAG. Journal of Basic and Applied Genetics, 2022 The present review aims to summarize the research carried out in relation to meiosis in birds, especially by observing the protein axes of the chromosomes in prophase I of meiosis. This line of research, initially developed in Argentina, has provided key
Pigozzi M.I.
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