Results 21 to 30 of about 6,519,238 (204)

The Ecm11-Gmc2 Complex Promotes Synaptonemal Complex Formation through Assembly of Transverse Filaments in Budding Yeast [PDF]

, 2013
During meiosis, homologous chromosomes pair at close proximity to form the synaptonemal complex (SC). This association is mediated by transverse filament proteins that hold the axes of homologous chromosomes together along their entire length. Transverse
Neil Humphryes, Wing‐Kit Leung, Bilge Argunhan, Yaroslav Terentyev, Martina Dvořáčková, Hideo Tsubouchi   +5 more
openalex   +5 more sources

FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis [PDF]

iScience, 2022
Summary: Meiotic prophase I is a prolonged G2 phase that ensures the completion of numerous meiosis-specific chromosome events. During meiotic prophase I, homologous chromosomes undergo synapsis to facilitate meiotic recombination yielding crossovers. It
Nobuhiro Tanno, Kazumasa Takemoto, Yuki Takada-Horisawa, Ryuki Shimada, Sayoko Fujimura, Naoki Tani, Naoki Takeda, Kimi Araki, Kei-ichiro Ishiguro   +8 more
doaj   +2 more sources

Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex [PDF]

Journal of Developmental Biology
Female gametogenesis is orchestrated by dynamic epigenetic modifications. In mammals, SETDB1, a histone H3K9 methyltransferase, is required for proper meiotic progression and early embryonic development.
Brigite Cabrita, Mary Enyioko, Rui Gonçalo Martinho   +2 more
doaj   +2 more sources

Synaptonemal Complex Central Region Proteins Promote Localization of Pro-crossover Factors to Recombination Events During Caenorhabditis elegans Meiosis [PDF]

Genetics, 2019
Errors during meiosis are the leading cause of birth defects and miscarriages in humans. Thus, the coordinated control of meiotic events is critical for the faithful inheritance of the genome with each generation...
Cori K. Cahoon, Jacquellyn M Helm, Diana E. Libuda   +2 more
semanticscholar   +2 more sources

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2018
Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1
Qianyan Li, Takamune T Saito, Marina Martinez-Garcia, Alison J Deshong, Saravanapriah Nadarajan, Katherine S Lawrence, Paula M Checchi, Monica P Colaiacovo, JoAnne Engebrecht   +8 more
doaj   +2 more sources

Identification of novel synaptonemal complex components in C. elegans [PDF]

J Cell Biol, 2020
The synaptonemal complex (SC) is a zipper-like protein structure that forms between paired homologous chromosomes during meiosis. Hurlock et al. discover two novel SC components, SYP-5 and SYP-6, in C.
Matthew E. Hurlock, Ivana Čavka, Lisa E. Kursel, Jocelyn Haversat, Matthew Wooten, Z. Nizami, Rashi Turniansky, P. Hoess, J. Ries, J. Gall, O. Rog, S. Köhler, Yumi Kim   +12 more
semanticscholar   +2 more sources

The synaptonemal complex stabilizes meiosis in allotetraploid Brassica napus and autotetraploid Arabidopsis thaliana. [PDF]

New Phytol
Summary Polyploidy plays a key role in genome evolution and crop improvement. The formation of bivalents rather than multivalents during meiosis of polyploids is essential to ensure meiotic stability and optimal fertility of the species. However, the mechanisms preventing multivalent recombination in polyploids remain obscure.
Zhang Y, Lv F, Wan Z, Geng M, Chu L, Cai B, Zhuang J, Ge X, Schnittger A, Yang C.   +9 more
europepmc   +2 more sources

SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56 [PDF]

J Cell Biol, 2020
The synaptonemal complex promotes faithful exchanges between homologous chromosomes during meiosis. Barbosa et al show that SCF-FBxo42 is important for assembly and maintenance of the synaptonemal complex by restricting the phosphatase PP2A-B56 level.
Pedro Barbosa, Liudmila Zhaunova, Simona Debilio, Verdiana Steccanella, V. Kelly, T. Ly, H. Ohkura   +6 more
semanticscholar   +2 more sources

Synaptonemal complex proteins modulate the level of genome integrity in cancers [PDF]

Cancer Sci, 2020
The synaptonemal complex (SC) is a proteinaceous structure that is transiently formed during meiosis to promote homologous recombination between maternal and paternal chromosomes. As this structure is required only for meiotic recombination, the proteins
N. Hosoya, K. Miyagawa
semanticscholar   +2 more sources

A new role for the synaptonemal complex in the regulation of meiotic recombination [PDF]

Genes Dev, 2020
This Outlook discusses Mu et al.’s finding showing that synaptonemal complex (SC) formation between individual chromosomes provides the feedback to down-regulate Spo11 activity, thereby revealing an additional function for the SC.
N. M. Hollingsworth
semanticscholar   +2 more sources