Results 171 to 180 of about 4,005 (212)

A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity

Krishnakumar S, Bose D, Bera M, Norman C, Timofeeva Y, Volynski K.   +5 more
europepmc   +2 more sources

Multidimensional Effects of Stress on Neuronal Exosome Levels and Simultaneous Transcriptomic Profiles. [PDF]

Biol Psychiatry Glob Open Sci
Kronman H, Singh A, Azam S, Guzman AS, Zelli D, Lau T, Dobbin J, Bigio B, Nasca C.   +8 more
europepmc   +1 more source

Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming. [PDF]

CNS Neurosci Ther
Xu H, Mi H, Cheng R, Gui T, Hu F, Yang Y, Cheng J, Xue Q.   +7 more
europepmc   +1 more source

The Extended-Synaptotagmins

Biochimica Et Biophysica Acta - Molecular Cell Research, 2017
The extended-synaptotagmins (tricalbins in yeast) derive their name from their partial domain structure similarity to the synaptotagmins, which are characterized by an N-terminal membrane anchor and cytosolically exposed C2 domains. However, they differ from the synaptotagmins in localization and function.
Yasunori Saheki
exaly   +4 more sources

Synaptotagmins in Neurodegeneration [PDF]

Anatomical Record, 2009
AbstractSynaptotagmins (Syts) are transmembrane proteins involved in the regulation of membrane trafficking. Here, we summarize literature data that provide growing evidence that several Syts are involved in the pathophysiological mechanisms of temporal lobe epilepsy and Parkinson's disease, as well as few reports related to brain ischemia and ...
Marko Živin
exaly   +3 more sources

Synaptotagmins: Why So Many? [PDF]

Journal of Biological Chemistry, 2002
Thomas C Südhof
exaly   +3 more sources

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Synaptotagmin and neurotransmitter release

Cell, 1993
William M. DeBello,’ Heinrich Bet Torri-Tarelli et al., 1985), and that this exocytosis is trig- gered by a rise in the concentration of Ca within presynap- tic terminals (Miledi, 1973). The source of this triggering Ca is the voltage-gated Ca channel, which is found in close proximity to the sites of exocytosis (Augustine et al., 1987).
W M, DeBello, H, Betz, G J, Augustine
openaire   +2 more sources

The diversity of synaptotagmin isoforms

Current Opinion in Neurobiology, 2020
The synaptotagmin family of molecules is known for regulating calcium-dependent membrane fusion events. Mice and humans express 17 synaptotagmin isoforms, where most studies have focused on isoforms 1, 2, and 7, which are involved in synaptic vesicle exocytosis. Recent work has highlighted how brain function relies on additional isoforms, with roles in
Anne C Wolfes, Camin Dean
openaire   +3 more sources

Synaptotagmin regulates mast cell functions

Immunological Reviews, 2001
Summary: Synaptotagmin(s) (Syts), are products of a gene family implicated in the control of Ca2+‐dependent exocytosis. Mast cells, specialized secretory cells that release mediators of inflammatory and allergic reactions in a process of regulated exocytosis, express Syt homologues and SNAREs (Soluble NSF Attachment proteins Receptors), which together ...
D, Baram, Y A, Mekori, R, Sagi-Eisenberg
openaire   +2 more sources

Synaptotagmins: Beyond Presynaptic Neurotransmitter Release

The Neuroscientist, 2019
Synaptotagmins (Syts) are well-established primary Ca2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the docking, priming, and fusion steps of exocytosis, as well as the tightly coupled exo-endocytosis, in presynapses.
Xuanang Wu, Shaoqin Hu, Xinjiang Kang, Changhe Wang   +3 more
openaire   +2 more sources