Results 111 to 120 of about 24,713 (214)

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, EarlyView.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Plasma supplemented with glycine is superior to standard plasma in reducing vascular permeability and organ injury via reduction of inflammation in an experimental traumatic shock model

Transfusion, EarlyView.
Abstract Background While plasma transfusion is a key resuscitation strategy, its mechanisms of benefit beyond coagulopathy correction remain unclear. Solvent detergent plasma, which contains high glycine levels and lacks inflammatory mediators, may offer advantages over fresh frozen plasma by preserving endothelial integrity and reducing inflammation.
Tarık Gözden, Bülent Ergin, Gözdenur Güneş, Ayşegül Kapucu, Nicole Juffermans   +4 more
wiley   +1 more source

Novel interactions of transglutaminase-2 with heparan sulphate proteoglycans: reflection on physiological implications [PDF]

, 2008
This mini-review brings together information from publications and recent conference proceedings that have shed light on the biological interaction between transglutaminase-2 and heparan sulphate proteoglycans. We subsequently draw hypothesis of possible
A Scarpellini, A. Scarpellini, AC Parsons, AD Cardin, B Mearns, C Zehe, DC Sane, DC Sane, E Verderio, E Verderio, E. A. M. Verderio, EA Verderio, ES Oh, F Echtermeyer, F Echtermeyer, G Fan, H Morita, J Filmus, J Hang, JF Qiu, JR Bishop, K Ishiguro, K Small, L Fesus, L Lorand, L Lorand, L Pellegrini, M Griffin, M Griffin, M Signorini, MA Stepp, MR Morgan, NJ Skill, P Grenard, P Stephens, PH Seeberger, Q Fan, R Gallo, RJ Richards, S Gambetti, S Yung, SA Wilcox-Adelman, SS Akimov, T. S. Johnson, TS Johnson, TS Johnson, TS Johnson, TS Johnson, V Gentile, X Li, XD Ren, ZA Haroon   +51 more
core   +1 more source

Commuting by bicycle (vs. by car) is associated with improved aerobic power, microvascular function and diminished CO2 output in the atmosphere

Experimental Physiology, EarlyView.
Abstract The study investigated whether bicycle compared with car commuting, over relatively small distances, has positive effects on physiological variables, cardiometabolic fitness and CO2 output in the atmosphere. Bike Commuters (11 M, 15 F; age [median value (interquartile range)] 51.5 (38.3–56.8) years; body mass index [BMI] 22.8 (21.0–24.1) kg m ...
Caterina Ursella, Giovanni Baldassarre, Lucrezia Zuccarelli, Federica Caponnetto, Francesco Curcio, Mattia D'Alleva, Maria De Martino, Elisabetta Fontanini, Andrea Palomba, Antonio Paolo Beltrami, Federico Formenti, Bruno Grassi   +11 more
wiley   +1 more source

Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans [PDF]

, 2018
Tsetse flies are the principal insect vectors of African trypanosomes—sleeping sickness in humans and Nagana in cattle. One of the tsetse fly species, Glossina morsitans morsitans, is host to the parasite, Trypanosoma brucei, a major cause of African ...
Acosta-Serrano, A, Guimond, S, Lima, M, Pelletier, J, Rogerson, E, Rose, C, Skidmore, MA, Taylor, S, Yates, E   +8 more
core   +5 more sources

Impaired nitric oxide‐dependent endothelial function in young male individuals with obesity before the onset of symptoms and complications

Experimental Physiology, EarlyView.
Abstract Endothelial dysfunction drives obesity‐related complications. Doppler ultrasound measurement of blood flow during 1‐min passive leg movements (PLM) is a valuable non‐invasive tool for assessing endothelial function and nitric oxide (NO)‐mediated vasodilation.
Lucrezia Zuccarelli, Giovanni Baldassarre, Adele Bondesan, Diana Caroli, Roberta De Micheli, Gabriella Tringali, Thomas Favaretto, Joanna Suraj‐Prazmowska, Anna Kurpinska, Joanna Majerczak, Stefan Chlopicki, Jerzy A. Zoladz, Alessandro Sartorio, Bruno Grassi   +13 more
wiley   +1 more source

Transcriptional Adaptations to Muscle Loading in a Murine Model of Achilles Tendinopathy

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Achilles tendinopathy limits mobility and decreases quality of life. Physical therapy (eccentric muscle loading) improves tendon function; however, the underlying mechanisms are unknown. This study investigated the effect of load magnitude and treatment duration in a mouse Achilles tendinopathy model.
Dylan C. Easley, Bruno C. Menarim, Robert W. Grange, P. Gunnar Brolinson, Vincent M. Wang, Linda A. Dahlgren   +5 more
wiley   +1 more source

Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

, 2015
Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane of mammalian tissues.
Parish, Christopher, Simon Davis, David Anak   +1 more
core   +1 more source

Extracellular matrix in hematopoiesis and hematologic malignancies [PDF]

, 2008
The extracellular matrix (ECM) is a complex structure composed of collagens, proteoglycans, glycosaminoglycans and adhesive glycoproteins. Interactions between the cells and the ECM are crucial to determine cell behavior, such as growth, death ...
Dreyfuss, Juliana Luporini, Oliveira, José Salvador Rodrigues de   +1 more
core   +3 more sources