Results 91 to 100 of about 107,687,715 (215)

Surface charge alterations in urinary extracellular vesicles mirror diabetic kidney disease pathophysiology

The FEBS Journal, EarlyView.
This study reveals that changes in the electrical charge, that is zeta potential of large extracellular vesicles (uEVs) found in urine, can reflect disease progression from diabetes to kidney scarring (fibrosis). With further clinical development, measurement of uEVs charge could provide a simple, noninvasive way to monitor disease progression and help
Melanie Tepuš, Maria Pia Savoca, Mabrouka Maamra, Conor J. Meehan, Dimitrios S. Goumenos, Timothy Johnson, Elisabetta A. M. Verderio   +6 more
wiley   +1 more source

Assessment of Thrombin Generation in Pediatric Patients on Extracorporeal Life Support: Impact of Bivalirudin and Other Anticoagulants

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Bivalirudin is an alternative anticoagulant to heparin and is widely used in pediatric extracorporeal life support (ECLS). Its activity is monitored using activated partial thromboplastin time (aPTT) and/or more specific tests such as plasma‐diluted thrombin time (dTT).
Vadim Kostousov, Karen Bruzdoski, Amir Navaei, Jun Teruya   +3 more
wiley   +1 more source

Acute exercise increases syndecan-1 and -4 serum concentrations

, 2019
The effects of acute and long-term exercise on syndecans and the relationship to insulin sensitivity are not fully explored. We aimed to examine the effects of acute and 12 weeks of exercise on (1) serum levels of syndecan-1 and -4, (2) gene expression ...
Birkeland, Kåre I., Kolset, Svein Olav, Drevon, Christian A, Reine, Trine M., Lee-Ødegård, Sindre   +4 more
core   +1 more source

Association of Syndecan-1 immunoexpression with epithelial dysplasia in oral verrucous carcinoma

Bangabandhu Sheikh Mujib Medical University Journal
Background: Oral verrucous carcinoma (OVC) is an uncommon variant of well-differentiated squamous cell carcinoma with an excellent prognosis. Epithelial dysplasia in OVC is a sign of a poorer prognosis.
Md. Akhtaruzzaman, Bishnu Pada Dey, Israt Jahan, Md. Mahabub Alam, Sultana Gulshana Banu   +4 more
doaj   +1 more source

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells

Frontiers in Oncology, 2020
The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and invasiveness.
Sampath Kumar Katakam, Paride Pelucchi, Cinzia Cocola, Rolland Reinbold, Israel Vlodavsky, Burkhard Greve, Martin Götte   +6 more
doaj   +1 more source

Low Soluble Syndecan-1 Precedes Preeclampsia

PLOS ONE, 2016
Syndecan-1 (Sdc1; CD138) is a major transmembrane heparan sulfate proteoglycan expressed on the extracellular, luminal surface of epithelial cells and syncytiotrophoblast, thus comprising a major component of the glycocalyx of these cells. The "soluble" (shed) form of Sdc1 has paracrine and autocrine functions and is normally produced in a regulated ...
Gandley, RE, Althouse, A, Jeyabalan, A, Bregand-White, JM, McGonigal, S, Myerski, AC, Gallaher, M, Powers, RW, Hubel, CA   +8 more
openaire   +4 more sources

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

MCT1‐mediated bidirectional propionate transport across human placental syncytiotrophoblast layer: insights from a trophoblast stem cell‐derived barrier model

The Journal of Physiology, EarlyView.
Abstract figure legend Propionate in the fetal circulation is thought to originate from fermentation of dietary fibre by the maternal gut microbiota. However, the mechanism of transplacental transport has remained unclear. Here, we measured propionate permeability using a placental barrier model generated by differentiating human placental trophoblast ...
Toshiaki Tsuchitani, Rin Midorikawa, Akari Kasuya, Saki Noguchi, Kohei Yamamoto, Tomohiro Nishimura, Hirokazu Kaji, Takeshi Hori, Masatoshi Tomi   +8 more
wiley   +1 more source

Gas exchange and pulmonary stress variations during SCUBA and breath‐hold diving in open seawater

The Journal of Physiology, EarlyView.
Abstract figure legend Healthy, trained divers were studied before, during and after diving in open seawater with different techniques. SCUBA divers (diving to 15 or 40 m with air; cycling at depth) and breath‐hold divers (BHDs; sled‐assisted dives to 15, 25 or 40 m) underwent underwater and surface arterial blood gas (ABG) sampling.
Matteo Paganini, Tommaso Antonio Giacon, Simona Mrakic‐Sposta, Luca Martani, Danilo Cialoni, Lorenzo Zucchi, Vincenzo Maffei, Rosario Cifali, Mariano Marmo, Enrico M Camporesi, Richard E Moon, Gerardo Bosco   +11 more
wiley   +1 more source

Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains

, 2013
Syndecans are transmembrane heparan sulfate proteoglycans with roles in cell proliferation, differentiation, adhesion, and migration. They have been associated with multiple functions in tumour progression, through their ability to interact with a wide ...
Manon-Jensen, Tina, Tina Manon‐Jensen, Couchman, John R, Hinke A. B. Multhaupt, Multhaupt, Hinke A B, John R. Couchman   +5 more
core   +1 more source