Results 111 to 120 of about 107,687,715 (215)

Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment.

, 2009
International audienceHeparan sulfate proteoglycan receptor syndecan-1 interacts with the carboxyl-terminal LG4/5 domain in laminin 332 (alpha3LG4/5) and participates in cell adhesion and spreading.
Sulka, Béatrice, Letourneur, François, Lortat-Jacob, Hugues, Terreux, Raphael, Rousselle, Patricia   +4 more
core   +1 more source

Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction

Annals of Intensive Care, 2017
Background Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured plasma levels of syndecan-1, a marker
Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache, Lorraine B. Ware   +6 more
doaj   +1 more source

Site‐specific O‐glycans influence lacritin structure and multimerization in tears

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Lacritin is an abundantly expressed glycoprotein in tear fluid and plays key roles in immune response, tear secretion, and bacterial killing. These biological functions are tightly regulated through several biochemical mechanisms including multimerization, proteolysis, and alternative splicing, especially within its C‐terminal domain.
Vincent Chang, Ryan J. Chen, Isaac Lian, Madilynn Hamilton, Keira E. Mahoney, Jeff Romano, Gordon Laurie, Stacy A. Malaker   +7 more
wiley   +1 more source

In vivo and in vitro analysis of syndecan-1 and syndecan-4 cleavage fragments as regulators of cell migration [PDF]

, 2016
Syndecan-1 and -4 are cell surface heparan sulphate proteoglycans that are predominantly found on endothelial and epithelial cells. The core protein consists of an ectodomain carrying heparan sulphate and chondroitin sulphate rich glycosaminoglycan ...
Pasqualon, Tobias
core  

Pancreatic Cancer Early Detection Biomarkers for High‐Risk Individuals: Insights From the PRECEDE Consortium

International Journal of Cancer, Volume 159, Issue 8, Page 1873-1883, 15 October 2026.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington, Maria Raitses‐Gurevich, Giulio Innamorati, Phil A. Hart, Thomas M. Wilkie, Noam Tau, Dana Brin, Doron Yablecovitch, Ido Laish, Dove Keith, Kurt Giles, Jennifer B. Permuth, Diane M. Simeone, George Zogopoulos, Randall E. Brand, John J. Graff, Julie Earl, On behalf of the PRECEDE Consortium, Nikhil Agarwal, Laufey Amundadottir, Michelle Anderson, Ajay Bansal, Todd Bauer, Georg Beyer, Yan Bi, Erkut Borazanci, Randy Brand, Teri Brentnall, Carol Burke, Darren Carpizo, Saurabh Chawla, Daniel Chung, Sourat Darabi, Michael Demeure, Timothy Donahue, Julie Earl, Whitney Espinel, James Farrell, Vigdís Fjóla Stefánsdóttir, Jared Forrester, Eitan Friedman, Paul Franklin, Srinivas Gaddam, Ana García García de Paredes, Steven Gallinger, Talia Golan, Ora Gordon, Robert Grant, William Greenhalf, Eli Marie Grindedal, Aaron Grossberg, Brenda Hafers, Heather Hannon, Sigurdís Haraldsdóttir, Stefán Haraldsson, Peter Hegyi, Melissa Hogg, Amy de Haar‐Holleman, Susan Hong, Greg Idos, Edward Kim, Fay Kastrinos, Bryson Katona, Vivek Kaul, Derk Klatte, Kelsey Klute, Kimberly Ku, Sonia Kupfer, Rich Kwon, Rosario Ligresti, James James Lin, Wei‐Chih (David) Liao, Aimee Lucas, Nipun Merchant, Andrew Metz, Whitney Maxwell, James McLoughlin, Sodech Miclette, Xavier Molero, Leticia Moreira, Takuji Okusaka Chigusa Morizane, Joanne Ngeow, Salvatore Paiella, Jennifer Permuth, Maricel Purcell, Joshua Raff, Vineet Rolston, Intan Schrader, Rosie Sears, Yan‐Shen Shan, Diane Simeone, Jens Siveke, Brett Sheppard, Tyler Stevens, Elena Stoffel, Dan Sussman, Margaret Tempero, Jose Trevino, Jennifer Valerin, Eva Vaquero, Ray Wadlow, Garrett Ward, David Weinberg, Ronald Wolf, Dana Zakalik, George Zogopoulos   +105 more
wiley   +1 more source

Altered Distribution and Expression of Syndecan-1 and -4 as an Additional Hallmark in Psoriasis

, 2022
Syndecans act as independent co-receptors to exert biological activities and their altered function is associated with many pathophysiological conditions.
Nikolaos Bikiaris, Koliakou, Eleni, Evangelia Kalloniati, Manthou Eleni, Ioanna Koumentakou, Elisabeth Lazaridou, Konstantinidou, Polyanthi, Michopoulou, Anna, Polyanthi Konstantinidou, Lazaridou, Elisabeth, Dimosthenis Miliaras, Dimosthenis, Miliaras, Anestakis, Doxakis, Patricia Rousselle, Bikiaris, Nikolaos, Eleni Koliakou, Koumentakou, Ioanna, Anna Michopoulou, Rousselle, Patricia, Doxakis Anestakis, Eleni, Manthou Maria, Kalloniati, Evangelia   +21 more
core   +1 more source

Endothelial Exostosin‐1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Endothelial Ext1 is essential for maintaining heparan sulfate–rich endothelial glycocalyx integrity. Loss of Ext1 reduces glycocalyx thickness, resulting in enhanced leukocyte adhesion, increased vascular permeability, and exaggerated inflammatory responses following lipopolysaccharide (LPS) challenge.
Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura, Ryo Kamidani, Yoshinori Kakino, Tomotaka Miura, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Akio Suzuki, Kazu Matsumoto, Nobuyuki Tetsuka, Shozo Yoshida, Yoichi Maekawa, Yu Yamaguchi, Hideshi Okada   +22 more
wiley   +1 more source

Predictors for readmission/death interacting with syndecan-1.

, 2021
Predictors for readmission/death interacting with syndecan-1.
Chihiro Takada (10507331), Kohei Kondo (11812869), Hideshi Okada (5797448), Hirotaka Asano (11812872), Takuma Ishihara (3394025), Soichiro Kano (11812866), Takahiro Yoshida (461333), Akio Suzuki (624761), Ayane Nishio (10507334), So Sampei (10507328), Takatomo Watanabe (10507346), Keiko Suzuki (216606), Takahito Miyake (10892397), Nagisa Miyazaki (10507343), Tomoaki Doi (750227), Yugo Wakayama (11812875), Ryo Kamidani (11812878), Ryu Yasuda (11812884), Kodai Suzuki (845919), Hirotsugu Fukuda (5587271), Itta Kawamura (709057), Shozo Yoshida (10507349), Hideaki Oiwa (11812887), Yuichiro Kitagawa (11174407), Yuki Kawasaki (3864160), Hiroyuki Tomita (3121689), Shinji Ogura (750231), Tetsuya Fukuta (11812881), Yoshinori Kakino (11812890), Hitoshi Matsuo (11812893)   +29 more
core   +1 more source

Syndecan-1 is not detected within the nucleus of cells expressing high levels of heparanase.

, 2013
Confocal microscopic z-stack images of (A) HPSE-low and (B) HPSE-high cells immunostained using antibody to syndecan-1. Blue (Hoechst stain) identifies nuclei; white identifies syndecan-1 within the nucleus (co-localization of Hoechst and syndecan-1 ...
Ligong Chen (259976), Ralph D. Sanderson (373871)   +1 more
core   +1 more source

Growth Factor–Induced Shedding of Syndecan-1 Confers Glypican-1 Dependence on Mitogenic Responses of Cancer Cells [PDF]

, 2005
The cell surface heparan sulfate proteoglycan (HSPG) glypican-1 is up-regulated by pancreatic and breast cancer cells, and its removal renders such cells insensitive to many growth factors. We sought to explain why the cell surface HSPG syndecan-1, which
Lander, Arthur D., Lopez-Burks, Martha, Murray Korc, Ding, Kan, Sánchez-Duran, José A, José Antonio Sánchez-Duran, Sánchez-Duran, José Antonio, Arthur D. Lander, Martha Lopez-Burks, Kan Ding, Lander, Arthur D, Korc, Murray   +11 more
core   +1 more source